Subcutaneous calcinosis is a well-recognized manifestation of systemic sclerosis (SSc), and is clinically apparent in about 25% of patients. It occurs in both limited and diffuse cutaneous disease, but is more common in patients with limited cutaneous SSc, particularly those with anti-centromere antibody1. The exact mechanism of calcinosis in SSc is unknown and currently there is no approved effective therapy. Although calcinosis usually occurs at …