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Research ArticleArticle

Longterm Safety and Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: A Cumulative Analysis of Up to 4.6 Years of Exposure

Mark C. Genovese, Andrea Rubbert-Roth, Josef S. Smolen, Joel Kremer, Majed Khraishi, Juan Gómez-Reino, Anthony Sebba, Robert Pilson, Sarah Williams and Ronald Van Vollenhoven
The Journal of Rheumatology June 2013, 40 (6) 768-780; DOI: https://doi.org/10.3899/jrheum.120687
Mark C. Genovese
From the Division of Rheumatology, Stanford University Medical Center, Palo Alto, California, USA; Department of Internal Medicine, University of Cologne, Cologne, Germany; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Center for Rheumatology, Albany Medical College, State University of New York, Albany, New York, USA; Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada; Rheumatology Unit Hospital, Clinical Universitario, Santiago, Spain; Department of Rheumatology, University of South Florida, Palm Harbor, Florida, USA; Hoffmann-La Roche Inc., Nutley, New Jersey, USA; PDBB-Biostatistics, Roche Products Limited, Welwyn Garden City, UK; and Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden.
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  • For correspondence: Genovese@stanford.edu
Andrea Rubbert-Roth
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Josef S. Smolen
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Joel Kremer
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Majed Khraishi
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Juan Gómez-Reino
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Anthony Sebba
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Robert Pilson
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Sarah Williams
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Ronald Van Vollenhoven
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Article Information

vol. 40 no. 6 768-780
DOI 
https://doi.org/10.3899/jrheum.120687
PubMed 
23457383

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication December 11, 2012
  • Published online June 1, 2013.

Article Versions

  • Latest version (March 1, 2013 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2013

Author Information

  1. Mark C. Genovese⇑,
  2. Andrea Rubbert-Roth,
  3. Josef S. Smolen,
  4. Joel Kremer,
  5. Majed Khraishi,
  6. Juan Gómez-Reino,
  7. Anthony Sebba,
  8. Robert Pilson,
  9. Sarah Williams and
  10. Ronald Van Vollenhoven
  1. From the Division of Rheumatology, Stanford University Medical Center, Palo Alto, California, USA; Department of Internal Medicine, University of Cologne, Cologne, Germany; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria; Center for Rheumatology, Albany Medical College, State University of New York, Albany, New York, USA; Memorial University of Newfoundland, St. John’s, Newfoundland and Labrador, Canada; Rheumatology Unit Hospital, Clinical Universitario, Santiago, Spain; Department of Rheumatology, University of South Florida, Palm Harbor, Florida, USA; Hoffmann-La Roche Inc., Nutley, New Jersey, USA; PDBB-Biostatistics, Roche Products Limited, Welwyn Garden City, UK; and Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden.
  2. M.C. Genovese, MD, Professor, Division of Rheumatology, Stanford University Medical Center; A. Rubbert-Roth, PhD, Professor, Department of Internal Medicine, University of Cologne; J.S. Smolen, MD, Professor, Division of Rheumatology, Department of Medicine III, Medical University of Vienna; J. Kremer, MD, Professor, Center for Rheumatology, Albany Medical College, State University of New York; M. Khraishi, MBBCh, FRCPC, Clinical Professor of Medicine (Rheumatology), Co-chair Human Investigation Committee, Memorial University of Newfoundland; J. Gómez-Reino, MD, Professor of Medicine, Head, Rheumatology Unit, Hospital Clinical Universitario; A. Sebba, MD, Assistant Clinical Professor, Department of Rheumatology, University of South Florida; R. Pilson, MS, Clinical Science Associate, Product Development, Immunology, Hoffmann-La Roche Inc.; S. Williams, MSc, Senior Statistical Scientist, PDBB-Biostatistics, Roche Products Limited; R. van Vollenhoven, MD, PhD, Senior Physician, Associate Professor, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna.
  1. Address correspondence to Prof. M.C. Genovese, Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA 94304, USA. E-mail: Genovese{at}stanford.edu

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The Journal of Rheumatology
Vol. 40, Issue 6
1 Jun 2013
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Longterm Safety and Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: A Cumulative Analysis of Up to 4.6 Years of Exposure
Mark C. Genovese, Andrea Rubbert-Roth, Josef S. Smolen, Joel Kremer, Majed Khraishi, Juan Gómez-Reino, Anthony Sebba, Robert Pilson, Sarah Williams, Ronald Van Vollenhoven
The Journal of Rheumatology Jun 2013, 40 (6) 768-780; DOI: 10.3899/jrheum.120687

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Longterm Safety and Efficacy of Tocilizumab in Patients with Rheumatoid Arthritis: A Cumulative Analysis of Up to 4.6 Years of Exposure
Mark C. Genovese, Andrea Rubbert-Roth, Josef S. Smolen, Joel Kremer, Majed Khraishi, Juan Gómez-Reino, Anthony Sebba, Robert Pilson, Sarah Williams, Ronald Van Vollenhoven
The Journal of Rheumatology Jun 2013, 40 (6) 768-780; DOI: 10.3899/jrheum.120687
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Keywords

TOCILIZUMAB
TREATMENT EFFICACY
SAFETY
RHEUMATOID ARTHRITIS

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Keywords

  • tocilizumab
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  • safety
  • rheumatoid arthritis

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