Treatment of 139 Pregnancies in Antiphospholipid-positive Women Not Fulfilling Criteria for Antiphospholipid Syndrome: A Retrospective Study

Article Figures & Data

Table 1

Incidence of antiphospholipid (aPL) antibodies in the various obstetrical profiles. Data are number (%).

Obstetrical Profile	N^*	aCL IgG		aCL IgM		Anti-ß₂-GPI IgG^**		Anti-ß₂-GPI IgM^**		LAC
Obstetrical Profile	N^*	Low	MH	Low	MH	Low	MH	Low	MH
Absence of obstetrical criteria (aPL carrier)	65^{^†} (46.8)	7 (10.8)	19 (29.2)	3 (4.6)	9 (13.8)	8 (12.3)	22 (33.8)	7 (10.8)	15 (23.1)	7 (10.8)
Incomplete obstetrical criteria	74^††(53.2)	13 (17.6)	15 (20.3)	6 (8.1)	13 (17.6)	8 (10.8)	11 (14.9)	16 (21.6)	13 (17.6)	0 (0.0)
Total	139 (100)	20 (14.4)	34 (24.5)	9 (6.5)	22 (15.8)	16 (11.5)	33 (23.7)	23 (16.5)	28 (20.1)	7 (5.0)

↵* No. pregnancies.
↵** Anti-ß₂-GPI IgG and IgM were not determined in 11 pregnancies. Low: low titer, ≥ 95th ≤ 99th. MH: medium or high titer, ≥ 99th.
↵† 40 women did not have previous pregnancies.
↵†† Of these, 46 women had had 2 abortions. LAC: lupus anticoagulant; aCL: anticardiolipin; GPI: glycoprotein.

Table 2

Frequencies of baseline variables in the groups treated or not treated with low-dose aspirin (LDA). All data are percent unless otherwise indicated.

Characteristic	LDA Group (N^* = 104)	Non-LDA Group (N^* = 35)
Average maternal age, yrs ± SD	34.8 ± 4.3	32.7 ± 3.4
Previous pregnancy losses	54.8	48.6
Autoimmune disease	45.2	45.7
Medium-high level of aCL IgG	17.3	45.7
Medium-high level of aCL IgM	15.7	23.1
Medium-high level of anti-ß₂-GPI IgG	23.5	36.4
Medium-high level of anti-ß₂-GPI IgM	19.6	30.8
Lupus anticoagulant	5.8	2.9

Table 3

Distribution of pregnancy treatment in the 2 obstetrical profiles.

Obstetrical Profile	No. Pregnancies	Prophylaxis with LDA, n^* (%)	No LDA, n^* (%)
Absence of obstetrical criteria (aPL carrier)	65	47 (72.3)	18 (27.7)
Incomplete obstetrical criteria	74	57 (77.0)	17 (23.0)
Total	139	104 (74.8)	35 (25.2)

Table 4

Pregnancy outcomes in groups receiving low-dose aspirin (LDA) and no LDA.

Outcome	Total Pregnancies, n (%)	LDA Group, n (%)	Non-LDA Group, n (%)	p
Abortions	9 (6.5)	8 (7.7)	1 (2.8)	NS^*
Births	130 (93.5)	96 (92.3)	34 (97.2)	NS^*
Gestational age at birth, wks ± SD	38.4 ± 2.1	38.4 ± 1.8	38.6 ± 2.8	NS^*
Birth weight, percentile ± SD	45.3 ± 26.4	45.3 ± 26.5	45.5 ± 26.5	NS^*

Table 5

Pregnancy outcome according to patients' obstetrical profile and treatment with low-dose aspirin (LDA).

Outcome	Absence of Obstetrical Criteria, n = 65 (%)	Incomplete Obstetrical Criteria, n = 74 (%)
Delivery > 34th wk	58 (89.2)	66 (89.2)
LDA treatment	41 (70.7)	51 (77.3)
No LDA	17 (29.3)	15 (22.7)
Delivery ≤ 34th wk	4 (6.1)	2 (2.7)
LDA treatment	4 (100)	0 (0)
No LDA	0 (0)	2 (100)
Abortions	3 (4.6)	6 (8.1)
LDA treatment	2 (66.7)	6 (100)
No LDA	1 (33.3)	0 (0)