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Research ArticleArticle

The SMILE Study — Safety of Methotrexate in Combination with Leflunomide in Rheumatoid Arthritis

PAUL BIRD, HEDLEY GRIFFITHS, KATHLEEN TYMMS, DAVE NICHOLLS, LYNDEN ROBERTS, MARK ARNOLD, SIMON BURNET, JULIEN de JAGER, JAMES SCOTT, JANE ZOCHLING and GEOFF LITTLEJOHN
The Journal of Rheumatology March 2013, 40 (3) 228-235; DOI: https://doi.org/10.3899/jrheum.120922
PAUL BIRD
From the Combined Rheumatology Practice, Sydney, New South Wales (NSW); Barwon Rheumatology Service, Geelong, Victoria (VIC); Canberra Rheumatology, Canberra, Australian Capital Territory; Coast Joint Care, Maroochydore, Queensland (QLD); The Townsville Hospital, Douglas, QLD; Orthopaedic & Arthritis Specialist Centre, Chatswood, NSW; Queen Elizabeth Hospital, Woodville, South Australia; Olser House, Southport, QLD; Roche Products Pty Ltd, Dee Why; Menzies Research Institute Tasmania, Hobart, Tasmania; and Monash Medical Centre, Clayton, VIC, Australia.
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  • For correspondence: pbird{at}optimusresearch.com.au
HEDLEY GRIFFITHS
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KATHLEEN TYMMS
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DAVE NICHOLLS
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LYNDEN ROBERTS
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MARK ARNOLD
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SIMON BURNET
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JULIEN de JAGER
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JAMES SCOTT
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JANE ZOCHLING
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GEOFF LITTLEJOHN
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Article Information

vol. 40 no. 3 228-235
DOI 
https://doi.org/10.3899/jrheum.120922
PubMed 
23322457

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Accepted for publication November 6, 2012
  • Published online March 1, 2013.

Article Versions

  • Latest version (January 15, 2013 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2013

Author Information

  1. PAUL BIRD⇓,
  2. HEDLEY GRIFFITHS,
  3. KATHLEEN TYMMS,
  4. DAVE NICHOLLS,
  5. LYNDEN ROBERTS,
  6. MARK ARNOLD,
  7. SIMON BURNET,
  8. JULIEN de JAGER,
  9. JAMES SCOTT,
  10. JANE ZOCHLING and
  11. GEOFF LITTLEJOHN
  1. From the Combined Rheumatology Practice, Sydney, New South Wales (NSW); Barwon Rheumatology Service, Geelong, Victoria (VIC); Canberra Rheumatology, Canberra, Australian Capital Territory; Coast Joint Care, Maroochydore, Queensland (QLD); The Townsville Hospital, Douglas, QLD; Orthopaedic & Arthritis Specialist Centre, Chatswood, NSW; Queen Elizabeth Hospital, Woodville, South Australia; Olser House, Southport, QLD; Roche Products Pty Ltd, Dee Why; Menzies Research Institute Tasmania, Hobart, Tasmania; and Monash Medical Centre, Clayton, VIC, Australia.
  2. OPAL QUMI is supported by Roche Products Pty Ltd ( Australia). Dr. Bird, Dr. Griffiths, Dr. Nicholls, Dr. Tymms, Dr. Littlejohn, and Dr. Zochling are members of advisory boards and received grant support or honoraria as speakers from Roche.
  3. P. Bird, BMed (Hons), FRACP, PhD, Grad Dip (MRI), Rheumatologist, Combined Rheumatology Practice; H. Griffiths, MBBS, FRACP, Rheumatologist, Barwon Rheumatology Service; K. Tymms, MBBS, FRACP, Professor of Medicine, Canberra Rheumatology; D. Nicholls, BHB, MBChB, FRACP, Rheumatologist, Coast Joint Care; L. Roberts, MBBS, PhD, Associate Professor of Medicine, The Townsville Hospital; M. Arnold, MBBS, FRACP, Professor of Medicine, Orthopaedic & Arthritis Specialist Centre; S. Burnet, MBBS, FRACP, Rheumatologist, Queen Elizabeth Hospital; J. de Jager, MBBS, FRACP, Professor of Medicine, Olser House; J. Scott, BSc, Medical Manager, Roche Products Pty Ltd; J. Zochling, MBBS, FRACP, MMed(ClinEpi), PhD, Rheumatologist, Menzies Research Institute Tasmania; G. Littlejohn, MD, MPH, MBBS, FRACP, Professor of Medicine, Monash Medical Centre.
  1. Address correspondence to Dr. P. Bird, Combined Rheumatology Practice, Suite 4, Level 1, 19 Kensington St., Kogarah, NSW 2217, Australia. E-mail: pbird{at}optimusresearch.com.au

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The Journal of Rheumatology
Vol. 40, Issue 3
1 Mar 2013
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The SMILE Study — Safety of Methotrexate in Combination with Leflunomide in Rheumatoid Arthritis
PAUL BIRD, HEDLEY GRIFFITHS, KATHLEEN TYMMS, DAVE NICHOLLS, LYNDEN ROBERTS, MARK ARNOLD, SIMON BURNET, JULIEN de JAGER, JAMES SCOTT, JANE ZOCHLING, GEOFF LITTLEJOHN
The Journal of Rheumatology Mar 2013, 40 (3) 228-235; DOI: 10.3899/jrheum.120922

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The SMILE Study — Safety of Methotrexate in Combination with Leflunomide in Rheumatoid Arthritis
PAUL BIRD, HEDLEY GRIFFITHS, KATHLEEN TYMMS, DAVE NICHOLLS, LYNDEN ROBERTS, MARK ARNOLD, SIMON BURNET, JULIEN de JAGER, JAMES SCOTT, JANE ZOCHLING, GEOFF LITTLEJOHN
The Journal of Rheumatology Mar 2013, 40 (3) 228-235; DOI: 10.3899/jrheum.120922
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Keywords

RHEUMATOID ARTHRITIS
METHOTREXATE
LEFLUNOMIDE

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Keywords

  • rheumatoid arthritis
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