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LetterLetter

Genetic Interactions Between BANK1 and BLK in Chinese Patients with Systemic Lupus Erythematosus

XU-JIE ZHOU, YUAN-YUAN QI, FA-JUAN CHENG and HONG ZHANG
The Journal of Rheumatology October 2013, 40 (10) 1772-1773; DOI: https://doi.org/10.3899/jrheum.130477
XU-JIE ZHOU
Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
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YUAN-YUAN QI
Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
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FA-JUAN CHENG
Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
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HONG ZHANG
Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.
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  • For correspondence: hongzh@bjmu.edu.cn
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    Table 1.

    Replications of association between BANK1 and BLK polymorphisms with systemic lupus erythematosus.

    GeneChromosomeSNPRisk AlleleFrequency (%)pOR (95% CI)
    CaseControl
    BANK14rs10516487G89.5686.870.061.30 (0.99–1.71)
    BLK8rs2736340T78.3172.653.27 × 10−31.36 (1.11–1.67)
    • SNP: single-nucleotide polymorphism.

    • View popup
    Table 2.

    Genetic interaction analysis between BANK1 and BLK polymorphisms with systemic lupus erythematosus. The attributable proportion due to interaction (AP) was 0.36; and the relative excess risk due to interation (RERI) was 0.17.

    BANK1BLK
    rs10516487 AA+AGrs2736340 CC+CTrs2736340 TT
      No. cases/controls35/5661/67
      p—0.18
      OR (95% CI)1.0 (reference)1.46 (0.84–2.52)
    rs10516487 GG
      No. cases/controls156/191246/185
      p0.271.21 × 10−3
      OR (95% CI)1.31 (0.82–2.10)2.13 (1.34–3.38)
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The Journal of Rheumatology
Vol. 40, Issue 10
1 Oct 2013
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Genetic Interactions Between BANK1 and BLK in Chinese Patients with Systemic Lupus Erythematosus
XU-JIE ZHOU, YUAN-YUAN QI, FA-JUAN CHENG, HONG ZHANG
The Journal of Rheumatology Oct 2013, 40 (10) 1772-1773; DOI: 10.3899/jrheum.130477

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Genetic Interactions Between BANK1 and BLK in Chinese Patients with Systemic Lupus Erythematosus
XU-JIE ZHOU, YUAN-YUAN QI, FA-JUAN CHENG, HONG ZHANG
The Journal of Rheumatology Oct 2013, 40 (10) 1772-1773; DOI: 10.3899/jrheum.130477
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