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Research ArticleArticle

Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial

DÉSIRÉE VAN DER HEIJDE, EDWARD C. KEYSTONE, JEFFREY R. CURTIS, ROBERT B. LANDEWÉ, MICHAEL H. SCHIFF, DINESH KHANNA, TORE K. KVIEN, LUCIAN IONESCU, LEON M. GERVITZ, OWEN R. DAVIES, KRISTEL LUIJTENS and DANIEL E. FURST
The Journal of Rheumatology July 2012, 39 (7) 1326-1333; DOI: https://doi.org/10.3899/jrheum.111171
DÉSIRÉE VAN DER HEIJDE
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  • For correspondence: d.vanderheijde@kpnplanet.nl
EDWARD C. KEYSTONE
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JEFFREY R. CURTIS
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ROBERT B. LANDEWÉ
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MICHAEL H. SCHIFF
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DINESH KHANNA
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TORE K. KVIEN
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LUCIAN IONESCU
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LEON M. GERVITZ
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OWEN R. DAVIES
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KRISTEL LUIJTENS
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DANIEL E. FURST
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    Figure 1.

    Response with certolizumab pegol (CZP) 200 mg plus methotrexate. A. Percentage of patients with DAS28 improvement < 1.2 up to Week 12 and percentage who subsequently had LDA at Year 1. B. Percentage of patients who achieved LDA at Year 1 by time to and magnitude of initial DAS28 response. LDA: low disease activity defined as DAS28(ESR) ≤ 3.2.

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    Table 1.

    LDA at Year 1 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX), who failed to achieve certain DAS28 decreases within the first 12 weeks of treatment (ITT population; N = 393). LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving a particular DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively. ITT: intent-to-treat.

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    Table 2.

    Probability to achieve LDA at Year 1 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX) according to baseline DAS28 ≤ 6.34. LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving a particular DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively.

    Table 2.
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    Table 3.

    Probability to achieve LDA at Year 1 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX) according to baseline DAS28 > 6.34 to ≤ 6.95. LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving a particular DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively.

    Table 3.
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    Table 4.

    Probability to achieve LDA at Year 1 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX) according to baseline DAS28 > 6.95 to ≤ 7.48. LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving a particular DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively.

    Table 4.
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    Table 5.

    Probability to achieve LDA at Year 1 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX) according to baseline DAS28 > 7.48. LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving a particular DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively. ITT: intent-to-treat.

    Table 5.
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    Table 6.

    LDA at both Years 1 and 2 among patients treated with certolizumab pegol (CZP) 200 mg plus methotrexate (MTX) who failed to achieve DAS28 decreases within the first 12 weeks of treatment (ITT population; N = 393). LDA: low disease activity defined as DAS28(ESR) ≤ 3.2; n: number of patients not achieving each DAS28 threshold (row) up to a particular timepoint (column). Grey, white, and black shading indicate > 10%, 5%–10%, and < 5% probability of achieving LDA at 1 year, respectively. ITT: intent-to-treat.

    Table 6.
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The Journal of Rheumatology
Vol. 39, Issue 7
1 Jul 2012
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Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial
DÉSIRÉE VAN DER HEIJDE, EDWARD C. KEYSTONE, JEFFREY R. CURTIS, ROBERT B. LANDEWÉ, MICHAEL H. SCHIFF, DINESH KHANNA, TORE K. KVIEN, LUCIAN IONESCU, LEON M. GERVITZ, OWEN R. DAVIES, KRISTEL LUIJTENS, DANIEL E. FURST
The Journal of Rheumatology Jul 2012, 39 (7) 1326-1333; DOI: 10.3899/jrheum.111171

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Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial
DÉSIRÉE VAN DER HEIJDE, EDWARD C. KEYSTONE, JEFFREY R. CURTIS, ROBERT B. LANDEWÉ, MICHAEL H. SCHIFF, DINESH KHANNA, TORE K. KVIEN, LUCIAN IONESCU, LEON M. GERVITZ, OWEN R. DAVIES, KRISTEL LUIJTENS, DANIEL E. FURST
The Journal of Rheumatology Jul 2012, 39 (7) 1326-1333; DOI: 10.3899/jrheum.111171
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