Article Figures & Data
Tables
- Table 1.
Patient characteristics by tumor necrosis factor-α inhibitor use. Data are number of patients (%) or median (interquartile range).
Characteristic Overall, n = 807 Never Used, n = 629 Ever Used, n = 178 p* Male 247 (31) 187 (30) 60 (34) 0.282 White 775 (96) 607 (96) 168 (94) 0.194 Hypertension 541 (67) 425 (68) 116 (65) 0.508 Diabetes 270 (34) 220 (35) 50 (28) 0.065 Positive rheumatoid factor (known = 662) 505 (76) 394 (76) 111 (77) 0.932 Medication use (ever) NSAID 386 (48) 290 (46) 96 (54) 0.078 Steroids 542 (67) 415 (66) 127 (71) 0.197 Hydroxychloroquine 237 (29) 194 (31) 43 (24) 0.062 Methotrexate 369 (46) 260 (41) 109 (61) < 0.001 Etanercept 98 (12) — 98 (55) Adalimumab 59 (7) — 59 (33) Infliximab 27 (3) — 27 (15) Statins 343 (43) 264 (42) 79 (44) 0.634 Statin potency Low 44 (5) 35 (6) 9 (5) 0.792 Medium 171 (21) 135 (21) 36 (20) 0.721 High 152 (19) 114 (18) 38 (21) 0.331 Other lipid lowering 76 (9) 57 (9) 19 (10) 0.698 Age at RA diagnosis, yrs 60.0 (51–71) 62.0 (53–71) 55.0 (48–63) < 0.001 BMI (known = 783) 29.8 (26–35) 29.8 (26–34) 29.9 (26–36) 0.178 BMI maximum 32.5 (28–38) 32.5 (28–38) 32.4 (28–39) 0.640 BMI closest to RA diagnosis 29.8 (26–35) 29.8 (26–35) 29.7 (26–35) 0.834 Initial LDL 105 (82–130) 118 (91–144) 118 (97–140) 0.515 Initial HDL 53 (43–65) 57 (47–69) 60 (49–71) 0.129 Initial triglyceride 134.5 (97–199) 154 (112–219) 168 (118–249) 0.134 Initial total cholesterol 190 (165–219) 204 (173–237) 201 (185–231) 0.394 ESR (known = 673) 23.5 (12–41) 25 (12.5–42.5) 22 (10.7–34) 0.018 -
↵* Chi-square tests (frequencies) or Wilcoxon’s test (medians). NSAID: nonsteroidal antiinflammatory drugs; RA: rheumatoid arthritis; BMI: body mass index; LDL: low-density lipoprotein; HDL: high-density lipoprotein; ESR: erythrocyte sedimentation rate.
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- Table 2.
Final adjusted longitudinal model* estimates for tumor necrosis factor-α (TNF-α) inhibitor use status. Values are median (interquartile range).
Total on TNF-α Inhibitors All No Statins No Statins or Diabetes Total cholesterol (TC) 1.55 (−2.93, 6.04) 3.45 (−3.17, 10.07) 0.33 (−6.93, 7.59) HDL 0.42 (−0.94, 1.78) 1.48 (−0.75, 3.70) 1.47 (−1.17, 4.10) LDL −1.73 (−5.52, 1.99) −2.18 (−7.52, 3.16) −0.62 (−6.67, 5.43) Triglyceride 9.11 (−1.56, 19.77) 13.31 (−2.45, 29.08) 2.43 (−13.77, 18.62) TC/HDL 0.004 (−0.12, 0.13) −0.01 (−0.19, 0.16) −0.06 (−0.26, 0.14) LDL/HDL −0.03 (−0.12, 0.07) −0.05 (−0.18, 0.08) −0.05 (−0.20, 0.10) -
↵* Adjusted for sex, age at RA diagnosis, race, body mass index (time-varying), rheumatoid factor (yes/no), diabetes, hypertension, and use (time-varying) of steroids, nonsteroidal antiinflammatory drugs, methotrexate, hydroxychloroquine, statins (classified as none, low, medium, high potency), and other lipid-lowering medications. HDL: high-density lipoprotein; LDL: low-density lipoprotein.
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