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EditorialEditorial

Can We Identify Patients with Microscopic Polyangiitis Who Are at Risk of Relapse?

RAASHID A. LUQMANI
The Journal of Rheumatology March 2012, 39 (3) 455-457; DOI: https://doi.org/10.3899/jrheum.111602
RAASHID A. LUQMANI
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Microscopic polyangiitis (MPA) is an uncommon but not rare form of antineutrophil cytoplasm antibody (ANCA)-associated primary small-vessel vasculitis with a worldwide prevalence1. Conventional treatment is cyclophosphamide (CYC) and glucocorticoids, without which mortality is very high2. The usual clinical presentation is significant renal disease; untreated it will lead to endstage renal failure in many cases3.

Early identification and treatment of MPA is important to prevent mortality but also in the hope of reducing longterm complications. Even with treatment, the vasculitides have a tendency to relapse3,4,5,6,7,8,9. The definition of relapse varies across studies, but this has been resolved to some extent by a consensus on conducting clinical trials in vasculitis10. Overall, the relapse rate can be up to 35% in ANCA-associated vasculitis, largely due to the very high rates of relapse in patients who have granulomatosis with polyangiitis (an extremely uncommon condition in Japan compared to Europe and North America1) but is reportedly much lower in MPA (around 8%11). By contrast, mortality, particularly for severe disease, is around 24%–27%12.

In the current issue of The Journal, a group from Okayama, Japan, report on the risk factors associated with relapse13 in a retrospective study of a cohort of 62 patients with MPA. The most consistent finding was that rapid reduction of glucocorticoid therapy during the maintenance phase of treatment (> 0.86 mg per month) was a strong predictor for relapse. This is in keeping with a recent metaanalysis14 of 983 patients identified from previous studies. In the metaanalysis, patients who received a longer course of glucocorticoid therapy (more than 12 months) for their ANCA-associated vasculitis suffered fewer relapses than those given shorter courses (up to 12 months). However, the metaanalysis is inevitably weakened by the incomplete and variable description of the nature of relapses experienced by patients. Further, in the recent report of outcomes from a study looking at intravenous pulse high-dose CYC compared to continuous daily oral CYC in patients with ANCA-associated vasculitis9,15, although there was no difference in terms of mortality or renal impairment, relapse rates differed, being much greater in patients treated with pulse CYC (40%) compared to continuous daily oral treatment (21%). This was independent of glucocorticoid therapy because the glucocorticoid regimen was exactly the same in both arms. Of the original 149 patients included in the study, 71 had MPA, but the majority of relapses occurred in patients who were proteinase 3 (PR3) ANCA-positive.

By contrast, in the study by Wada, et al13, the mortality of patients was low (only 6.5%) in contrast with US, European, and previous Japanese data16. In the latter study16, which followed over 1700 patients with rapidly progressive glomerulonephritis (of whom around 19% had MPA), the 6-month survival rates were between 73% and 82%. In addition, 53% of cases were managed with glucocorticoids alone. This is at significant variance with standard management of MPA in Europe or the US, which would include use of CYC2. The overall relapse rate in the current Japanese study13 was 24%, suggesting that relapse was precipitated by rapid reduction in glucocorticoid doses (by more than 0.8 mg per month); while this was independent of the use of concomitant immunosuppressant agents, the absolute numbers of patients who received CYC in the study were small given that only half the patients were actually treated with concomitant immunosuppressant agents. Decisions to introduce cytotoxic agents were based on the level of disease activity at diagnosis as measured using a BVAS (Birmingham Vasculitis Activity Score17,18) of 10 points or more. In practice, patients who have rapidly progressive glomerulonephritis will always score a BVAS of at least 10 points. The definition of relapse used in the study was for at least one new item of BVAS. Of the cases, 14 were defined as having major relapse, whereas only one was defined as having minor relapse. Relapse occurred at around 21 months following initial treatment. There was an impressive 12-fold difference in relapse rate according to how rapidly glucocorticoids were withdrawn. It is not clear whether the patients who relapsed were the ones who had been treated with glucocorticoids alone (and by definition had milder disease because their initial BVAS score would have been < 10); therefore we can only speculate on what influence the CYC may or may not have had in controlling disease. As reported in previous studies, relapse was associated with increased cumulative damage as measured by the Vasculitis Damage Index19, although the amount of damage accumulating as a result of relapse was less than that achieved during the initial presentation, confirming previous findings20. Patients who relapsed were more likely to have myeloperoxidase (MPO)-ANCA (67% of patients were MPO-positive vs 45% PR3-ANCA-positive, but this was not statistically significant, probably because of the low numbers); this contrasts with the much lower number of relapses (around 8%) in MPA, as reported11. A metaanalysis of 18 studies examining the relationship of ANCA status to relapse reported that a rise in ANCA or persistence of ANCA titer during a period of clinical remission had only a modest predictive value for subsequent relapse7.

Overall, Wada and colleagues13 present a cohort of patients with MPA who were given relatively mild treatment, whose relapse rate was similar to that in other studies, and who accumulated damage subsequent to major relapses. We assume that more aggressive immunosuppression was then used in response to their relapse. It is possible that undertreatment, i.e., lack of use of concomitant immunosuppressant, may have contributed to the relapse risk; but, in keeping with other studies, glucocorticoids remain an important factor in protecting patients against relapse.

Because this was not a controlled trial, patients were treated individually, with wide variation in starting dose (20–60 mg per day). Therefore, we have to consider other influences relevant to the findings in the study, including duration of the induction phase, starting dose and reduction rate of glucocorticoids and use of concomitant immunosuppression during induction, starting dose of glucocorticoid therapy, and use of concomitant immunosuppression in the maintenance phase. The relatively small size of the cohort precludes this kind of detailed analysis, but it is useful to consider how these factors should be incorporated into future therapeutic studies in vasculitis.

Thus, despite their acute and cumulative toxicity, glucocorticoids remain part of the current therapeutic resources for treating ANCA-associated vasculitis. Meanwhile, the search must continue for therapeutic strategies in vasculitis that will reduce or eliminate our ongoing dependence on glucocorticoids.

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Can We Identify Patients with Microscopic Polyangiitis Who Are at Risk of Relapse?
RAASHID A. LUQMANI
The Journal of Rheumatology Mar 2012, 39 (3) 455-457; DOI: 10.3899/jrheum.111602

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Can We Identify Patients with Microscopic Polyangiitis Who Are at Risk of Relapse?
RAASHID A. LUQMANI
The Journal of Rheumatology Mar 2012, 39 (3) 455-457; DOI: 10.3899/jrheum.111602
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