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Meeting ReportAnnual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), Miami, Florida, USA, December 9–11, 2010

Update on Biomarkers in Psoriatic Arthritis: A Report from the GRAPPA 2010 Annual Meeting

OLIVER FITZGERALD and VINOD CHANDRAN
The Journal of Rheumatology February 2012, 39 (2) 427-430; DOI: https://doi.org/10.3899/jrheum.111241
OLIVER FITZGERALD
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  • For correspondence: oliver.fitzgerald@ucd.ie
VINOD CHANDRAN
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    Table 1.

    Recently identified biomarkers for psoriatic disease.

    BiomarkerScreening*Disease ActivityTreatment ResponseRadiographic Change†
    Peripheral blood/serum/plasma
      Bone alkaline phosphatase✓
      C-reactive protein✓✓✓✓
      Cartilage oligomeric matrix protein✓✓
      Ratio of C-propeptide of type II collagen to collagen fragment neoepitopes Col2–3/4 (long mono)✓
      Interleukin 6 (IL-6)✓✓
      Matrix metalloproteinase-3✓✓✓
      Melanoma inhibitory activity✓
      Macrophage-colony stimulating factor✓
      Osteoprotegerin✓
      Circulating osteoclast precursors✓
      Receptor activator of nuclear factor kappa-B ligand✓
    Synovial fluid
      Chemokine (C-C motif) ligand 3✓✓
      IL-1✓✓
      IL-1 receptor antagonist✓✓
      IL-6✓✓
      IL-8✓✓
    Synovial tissue
      CD3-positive cells✓
    Skin
      IL-17 pathway genes✓
    • ↵* Screening indicates screening psoriasis patients for PsA.

    • ↵† Radiographic change indicates both erosions and new bone formation.

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The Journal of Rheumatology
Vol. 39, Issue 2
1 Feb 2012
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Update on Biomarkers in Psoriatic Arthritis: A Report from the GRAPPA 2010 Annual Meeting
OLIVER FITZGERALD, VINOD CHANDRAN
The Journal of Rheumatology Feb 2012, 39 (2) 427-430; DOI: 10.3899/jrheum.111241

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Update on Biomarkers in Psoriatic Arthritis: A Report from the GRAPPA 2010 Annual Meeting
OLIVER FITZGERALD, VINOD CHANDRAN
The Journal of Rheumatology Feb 2012, 39 (2) 427-430; DOI: 10.3899/jrheum.111241
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  • Global Partnering Opportunities and Challenges of Psoriasis and Psoriatic Arthritis in Latin America: A Report from the GRAPPA 2010 Annual Meeting
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Show more Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), Miami, Florida, USA, December 9–11, 2010

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