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Case ReportImages in Rheumatology

Eosinophilic Granuloma of the Middle Ear

SHIGEHARU UEKI, HIROYUKI YAMAUCHI, MASAHIDE TAKEDA and JUNICHI CHIHARA
The Journal of Rheumatology September 2011, 38 (9) 2005-2006; DOI: https://doi.org/10.3899/jrheum.110126
SHIGEHARU UEKI
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HIROYUKI YAMAUCHI
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MASAHIDE TAKEDA
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JUNICHI CHIHARA
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A 33-year-old woman with a 10-year history of Churg-Strauss syndrome (CSS) was referred to an otolaryngologist for subjective bilateral ear discharge. Examination of the ear discharge demonstrated heavy content of eosinophils with no significant microorganisms, including fungi, and otoendoscopy showed large masses protruding from bilateral middle ears (Figure 1). Her audiogram revealed moderate conductive hearing loss.

Figure 1.
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Figure 1.

Otoendoscopic images of large masses protruding from middle ears on admission. The patient was initially treated with local injection of triamcinolone with continuation of previous oral corticosteroid regimen (30 mg/day). Because the effect was insufficient, carbon dioxide laser vaporization was performed every few weeks.

She had vasculitis of skin and lung infiltration at the time of the initial diagnosis with CSS, but no signs of vasculitis were noted by previous physicians during at least 8 years of continuous oral prednisolone treatment (7.5 to 30 mg/day). Attempts to further taper oral corticosteroids failed because of recurrent asthmatic symptoms. On admission, she was negative for antineutrophil cytoplasmic autoantibodies and was treated with inhaled corticosteroid, theophylline, and oral prednisolone 30 mg/day. Fifteen months of treatment with local injection of triamcinolone and laser vaporization actively decreased the masses (Figure 2).

Figure 2.
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Figure 2.

After 15 months of treatment, the size of the granuloma decreased and the tympanic membranes regenerated.

Although rhinitis and/or sinusitis are common in CSS1, the frequency of otological manifestations is not well known. Some patients progressed to sensorineural hearing loss or to otomastoiditis, even to bone destruction2,3. Ishiyama and Canalis have reported the retrospective review of 5 cases with otological manifestations in the later stage of CSS3. All of them were highly responsive to systemic steroids, and successively maintained with low doses of oral prednisone (4 to 10 mg daily or every other day). In contrast, the flare in this patient was during the years of continuous corticosteroid treatment, suggesting a greater disease activity in the ear.

REFERENCES

  1. 1.↵
    1. Bacciu A,
    2. Bacciu S,
    3. Mercante G,
    4. Ingegnoli F,
    5. Grasselli C,
    6. Vaglio A,
    7. et al.
    Ear, nose and throat manifestations of Churg-Strauss syndrome. Acta Otolaryngol 2006;126:503–9.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Watanabe R,
    2. Ishii T,
    3. Harigae H
    . Churg-Strauss syndrome with exophthalmos and orbital bone destruction. Intern Med 2010;49:1463–4.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Ishiyama A,
    2. Canalis RF
    . Otological manifestations of Churg-Strauss syndrome. Laryngoscope 2001;111:1619–24.
    OpenUrlCrossRefPubMed
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1 Sep 2011
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Eosinophilic Granuloma of the Middle Ear
SHIGEHARU UEKI, HIROYUKI YAMAUCHI, MASAHIDE TAKEDA, JUNICHI CHIHARA
The Journal of Rheumatology Sep 2011, 38 (9) 2005-2006; DOI: 10.3899/jrheum.110126

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Eosinophilic Granuloma of the Middle Ear
SHIGEHARU UEKI, HIROYUKI YAMAUCHI, MASAHIDE TAKEDA, JUNICHI CHIHARA
The Journal of Rheumatology Sep 2011, 38 (9) 2005-2006; DOI: 10.3899/jrheum.110126
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