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Research ArticlePediatric Rheumatology
Open Access

Bone Health in Adult Men and Women with a History of Juvenile Idiopathic Arthritis

JUDITH THORNTON, STEPHEN R. PYE, TERENCE W. O’NEILL, DAVID RAWLINGS, ROGER M. FRANCIS, DEBORAH P.M. SYMMONS, DARREN M. ASHCROFT and HELEN E. FOSTER
The Journal of Rheumatology August 2011, 38 (8) 1689-1693; DOI: https://doi.org/10.3899/jrheum.101232
JUDITH THORNTON
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STEPHEN R. PYE
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TERENCE W. O’NEILL
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  • For correspondence: terence.o'neill@manchester.ac.uk
DAVID RAWLINGS
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ROGER M. FRANCIS
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DEBORAH P.M. SYMMONS
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DARREN M. ASHCROFT
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HELEN E. FOSTER
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Article Figures & Data

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    Table 1.

    Demographic and disease-related characteristics. All data are mean (SD) or n (%).

    CharacteristicsWomen, n = 71Men, n = 16Overall, n = 87
    Age, yrs28.7 (10.1)31.4 (13.8)29.2 (10.8)
    Height, m1.6 (0.1)1.7 (0.1)1.6 (0.9)
    Weight, kg60.2 (16.0)67.6 (18.6)61.5 (16.7)
    Body mass index, kg/m223.4 (5.3)24.1 (6.2)23.5 (5.5)
    Disease duration, yrs20.6 (11.0)24.0 (13.6)21.2 (11.5)
    Current smoker16 (22.5)2 (22.2)18 (22.5)
    Disease characteristics and treatment
    Disease subtype (ILAR)
      Systemic7 (9.9)5 (1.3)12 (13.8)
      Oligoarticular12 (16.9)3 (18.8)15 (17.2)
      Extended oligoarticular8 (11.3)08 (9.2)
      Polyarticular RF-positive17 (23.9)1 (6.3)18 (20.7)
      Polyarticular RF-negative21 (29.6)2 (12.5)23 (26.4)
      Psoriasis3 (4.2)2 (12.5)5 (5.8)
      Enthesitis-related2 (2.8)2 (12.5)4 (4.6)
      Other1 (1.41)1 (6.3)2 (2.3)
    RF-positive21 (29.6)1 (6.3)22 (25.3)
    HAQ score (0–3)1.3 (0.8)1.5 (0.8)1.3 (0.8)
    ESR, mm/h23.2 (20.0)21.0 (26.3)23.0 (20.5)
    CRP, mg/l17.8 (20.9)26.3 (29.2)19.2 (22.3)
    Large-joint arthroplasty (yes vs no)16 (22.5)4 (66.7)20 (26.0)
    Hip arthroplasty (yes vs no)15 (21.1)4 (66.7)19 (24.7)
    Knee arthroplasty (yes vs no)12 (16.9)4 (66.7)16 (20.8)
    Methotrexate (ever, yes vs no)20 (29.0)2 (25.0)22 (28.6)
    Other DMARD (ever, yes vs no)33 (46.5)6 (37.5)39 (44.8)
    Oral steroids (ever, yes vs no)34 (49.3)5 (62.5)39 (50.7)
    Duration of oral steroids, mo76.3 (90.1)19.0 (24.0)72.9 (88.5)
    • ILAR: International League of Associations for Rheumatology; RF: rheumatoid factor; HAQ: Health Assessment Questionnaire; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; DMARD: disease-modifying antirheumatic drug.

    • View popup
    Table 2.

    Areal bone mineral density (BMDa) and Z-score at the lumbar spine and total hip. Data are mean (95% CI).

    WomenMen
    BMDa
      Lumbar spine, g/cm20.982 (0.947, 1.018)1.028 (0.910, 1.146)
      Total hip, g/cm20.817 (0.761, 0.874)0.857 (0.665, 1.050)
    Z-score
      Lumbar spine−0.328 (−0.657, 0.001)−0.251 (−1.266, 0.764)
      Total hip−0.542 (−0.975, −0.109)−0.176 (−2.323, 1.971)
    • View popup
    Table 3.

    Influence of disease-related factors on areal bone mineral density (BMDa) at the lumbar spine and total hip. Results are expressed as ß-coefficient (95% CI) adjusted for age and sex.

    Lumbar Spine BMDa (g/cm2)Total Hip BMDa (g/cm2)
    Weight, kg0.005 (0.003, 0.007)*0.006 (0.003, 0.009)*
    Height, cm0.007 (0.004, 0.011)*0.012 (0.005, 0.019)*
    Age at scan, yrs0.004 (0.001, 0.007)*0.000 (−0.006, 0.006)
    Sex (F vs M)−0.046 (−0.136, 0.045)−0.040 (−0.195, 0.114)
    Disease duration, yrs−0.005 (−0.011, 0.001)−0.004 (−0.015, 0.006)
    HAQ score (0–3)−0.099 (−0.148, − 0.051)*−0.122 (−0.217, −0.026)*
    ESR, mm/h0.000 (−0.002, 0.003)0.002 (−0.004, 0.007)
    ESR, mm/h
      < 20ReferentReferent
      ≥ 20−0.007 (−0.110, 0.097)0.057 (−0.142, 0.255)
    CRP, mg/l−0.001 (−0.004, 0.001)−0.001 (−0.005, 0.003)
    RF-positive (yes vs no)0.023 (−0.058, 0.103)0.057 (−0.065, 0.178)
    Disease subtype
      OligoarticularReferentReferent
      Systemic−0.108 (−0.222, 0.007)−0.180 (−0.382, 0.022)
      Extended oligoarticular−0.034 (−0.167, 0.098)−0.280 (−0.496, −0.064)*
      Polyarticular RF-positive−0.101 (−0.205, 0.003)−0.098 (−0.266, 0.070)
      Polyarticular RF-negative−0.090 (−0.190, 0.009)−0.184 (−0.343, − 0.025)*
      Psoriasis0.036 (−0.116, 0.188)0.074 (−0.154, 0.302)
      Enthesitis-related0.212 (0.044, 0.379)*0.053 (−0.226, 0.333)
      Other−0.062 (−0.287, 0.163)0.072 (−0.267, 0.411)
    Oral corticosteroids (yes vs no)−0.143 (−0.211, −0.075)*−0.136 (−0.248, −0.024)*
    Methotrexate (yes vs no)−0.071 (−0.154, 0.013)0.015 (−0.112, 0.143)
    Large-joint replacement (yes vs no)−0.101 (−0.188, −0.013)*−0.194 (−0.343, −0.046)*
    • ↵* p < 0.05. RF: rheumatoid factor; HAQ: Health Assessment Questionnaire; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.

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The Journal of Rheumatology
Vol. 38, Issue 8
1 Aug 2011
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Bone Health in Adult Men and Women with a History of Juvenile Idiopathic Arthritis
JUDITH THORNTON, STEPHEN R. PYE, TERENCE W. O’NEILL, DAVID RAWLINGS, ROGER M. FRANCIS, DEBORAH P.M. SYMMONS, DARREN M. ASHCROFT, HELEN E. FOSTER
The Journal of Rheumatology Aug 2011, 38 (8) 1689-1693; DOI: 10.3899/jrheum.101232

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Bone Health in Adult Men and Women with a History of Juvenile Idiopathic Arthritis
JUDITH THORNTON, STEPHEN R. PYE, TERENCE W. O’NEILL, DAVID RAWLINGS, ROGER M. FRANCIS, DEBORAH P.M. SYMMONS, DARREN M. ASHCROFT, HELEN E. FOSTER
The Journal of Rheumatology Aug 2011, 38 (8) 1689-1693; DOI: 10.3899/jrheum.101232
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