Article Figures & Data
Tables
- Table 1.
Characteristics of 795 incident RA patients (1980–2007, Olmsted County, Minnesota) at RA incidence and during the followup. The values are given as number (%) if not indicated otherwise.
Variable At RA Incidence At Any Time During Followup Age, yrs, mean ± SD 55.3 ± 15.5 — Female 546 (69) — Length of followup, yrs, mean ± SD 9.7 ± 6.9 — Smoking status Current 171 (22) — Former 254 (33) — Alcohol abuse 54 (7) 63 (8) Hypertension 490 (65) 676 (88) Dyslipidemia 431 (57) 569 (74) Obesity (BMI ≥ 30 kg/m2) 302 (41) 368 (49) Family history of premature coronary heart disease 172 (22) — Personal history of coronary heart disease 72 (10) 170 (23) Diabetes mellitus 77 (11) 147 (20) -
BMI: body mass index.
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- Table 2.
RA characteristics and their associations with the risk of heart failure (HF) in 795 incident RA patients. Values are given as number (%) if not indicated otherwise.
Characteristics Value Hazard Ratio ** (95% CI), Adjusted for Age, Sex, and Calendar Year of RA Incidence RF-positive 527 (66) 1.6 (1.0, 2.5) ESR at RA incidence, mm/h, mean ± SD 24.2 ± 19.9 1.6 (1.2, 2.0)† ≥ 3 ESR ≥ 60 mm/h 99 (12) 2.1 (1.2, 3.5) Large-joint swelling 624 (78) 1.1 (0.7, 1.8) Joint erosions/destructive changes 424 (53) 1.1 (0.8, 1.7) Joint surgery Arthroplasty 134 (17) 1.5 (0.9, 2.5) Synovectomy 86 (11) 1.1 (0.6, 2.2) Rheumatoid nodules 266 (33) 1.1 (0.7, 1.7) Severe ExRA* 87 (11) 3.1 (1.9, 5.1) History of rheumatic fever 22 (3) 1.0 (0.4, 2.7) - Table 3.
Antirheumatic medications and their associations with risk of heart failure (HF) in 795 incident RA patients.
Antirheumatic Medications N (%) Hazard Ratio * (95% CI), Adjusted for Age, Sex, and Calendar Year of RA Incidence Used at any time Methotrexate 465 (58) 0.9 (0.6, 1.5) Hydroxychloroquine 475 (60) 0.9 (0.6, 1.4) Other DMARD 255 (32) 0.9 (0.5, 1.6) Biologic response modifiers 135 (17) 0.8 (0.2, 2.6) Corticosteroids 614 (77) 1.2 (0.7, 1.9) NSAID 732 (91) 1.0 (0.5, 1.9) Coxibs 386 (49) 1.5 (0.9, 2.3) ASA 330 (43) 1.0 (0.6, 1.7) Current use Methotrexate 0.5 (0.3, 0.9) Hydroxychloroquine 1.0 (0.5, 1.8) Other DMARD 0.5 (0.2, 1.5) Biologic response modifiers 0.5 (0.1, 3.5) Corticosteroids 2.0 (1.3, 3.2) -
↵* Significant (p < 0.05) hazard ratios are shown in bold type. DMARD: disease-modifying antirheumatic drugs; NSAID: nonsteroidal antiinflammatory drugs; ASA: acetylsalicylic acid for arthritis [> 6 tablets per day (> 1950 mg/day) for at least 3 months]
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