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Research ArticleOMERACT 10: 10th International Consensus Conference on Outcome Measures in Rheumatology, Kota Kinabalu, Borneo - May 4–8, 2010

Early Postoperative Mortality Following Joint Arthroplasty: A Systematic Review

JASVINDER A. SINGH, JOSEPH KUNDUKULAM, DANIEL L. RIDDLE, VIBEKE STRAND and PETER TUGWELL
The Journal of Rheumatology July 2011, 38 (7) 1507-1513; DOI: https://doi.org/10.3899/jrheum.110280
JASVINDER A. SINGH
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  • For correspondence: Jasvinder.md@gmail.com
JOSEPH KUNDUKULAM
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DANIEL L. RIDDLE
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VIBEKE STRAND
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PETER TUGWELL
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    Figure 1.

    The process of data collection and analysis.

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    Table 1.

    Study population characteristics.

    Characteristic30-day Mortality Cohort, mean (SD) or %90-day Mortality Cohort mean (SD) or %
    Mean age (SD), yrs67.4 (7.0)68.0 (6.8)
    % Female52.861.3
    % Caucasian80.591.2
    % Osteoarthritis65.182.5
    Mean body mass index28.9 (1.6)28.1 (2.7)
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    Table 2.

    30- and 90-day mortality rates by sex, underlying diagnosis, and bilaterality*.

    30-day Mortality90-day Mortality
    n/N (%)Relative Risk (95% CI)n/N (%)Relative Risk (95% CI)
    Sex
      Female156/32,612 (0.4)Reference382/37,392 (1.0)Reference
      Male635/33,797 (1.8)3.93 (3.30–4.68)195/18,382 (1.1)1.04 (0.87–1.23)
    Underlying diagnosis
      Osteoarthritis114/31,504 (0.4)Reference78/13,686 (0.3)Reference
      Rheumatoid arthritis20/7,174 (0.3)0.77 (0.48–1.24)4/481 (0.8)1.46 (0.53–4.00)
    Laterality
      Unilateral10,711/3,739,900 (0.3)Reference199/28,988 (0.6)Reference
      Bilateral765/167,069 (0.5)1.60 (1.49–1.72)22/2,916 (0.7)1.13 (0.73–1.76)
    • ↵* Since only a few studies provided numbers separately for sex, underlying diagnosis, and laterality, the mortality rates may differ from the overall rates, since these studies were a subset of all studies included.

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    Table 3.

    30-day mortality stratified by type of joint (hip vs knee vs both) and type of arthroplasty (primary vs revision vs both)* for elective surgery and all-comers.

    No. Studies**All Studies Combined (%)Underlying Indication for Arthroplasty Elective (%)All-comers† (%)
    Hip arthroplasty2,602/411,675 (0.63)
      Primary hip1148/6,703 (0.71)2,224/352,708 (0.63)
      Revision hip††622/7,371 (0.29)24/2,402 (1.0)
      Primary and revision combined590/30,714 (0.29)234/21,327 (1.1)
    Knee arthroplasty13,233/4,569,617 (0.29)
      Primary knee875/12,108 (0.62)1,277/372,444 (0.34)
      Revision knee††1—4/4,375 (0.1)
      Primary and revision combined711,881/4,185,030 (0.28)0/35 (0)
    • ↵* Since only a few studies provided numbers separately for knee and hip arthroplasty, the mortality rates may not reflect overall rates, these studies being a subset of all studies included.

    • ↵** One study could provide data for more than 1 group.

    • ↵† All-comers included studies where all patients were included and those in which there was no clear description of included patients.

    • ↵†† Revision numbers were often a subset of the mortality for the entire sample, frequently with primary arthroplasty constituting a large majority of cohort and high proportion of all deaths.

    • View popup
    Table 4.

    90-day mortality stratified by underlying type of joint (hip vs knee vs both) and type of arthroplasty (primary vs revision vs both)* for elective surgery and all-comers.

    No. Studies**Overall (all studies) (%)Underlying Indication for Arthroplasty Elective (%)All-comers† (%)
    Hip arthroplasty2,126/236,104 (0.9)
      Primary hip2395/46,007 (0.86)744/100,058 (0.74)
      Revision hip††8327/15,229 (2.15)38/3785 (1.0)
      Primary and revision combined6884/73,750 (1.19)103/16,289 (0.63)
    Knee arthroplasty2,432/393,540 (0.62)
      Primary knee8508/78,745 (0.65)1,921/313,586 (0.61)
      Revision knee††1—1/132 (0.76)
      Primary and revision combined1—3/1,209 (0.25)
    • ↵* Since only a few studies provided numbers separately for knee and hip arthroplasty, the mortality rates may not reflect overall rates, these studies being a subset of all studies included.

    • ↵** One study could provide data for more than 1 group.

    • ↵† All-comers included studies where all patients were included and those in which there was no clear description of included patients.

    • ↵†† Revision numbers were often a subset of the mortality for the entire sample, frequently with primary arthroplasty constituting a large majority of cohort and high proportion of all deaths.

    • View popup
    Table 5.

    Comparison of primary and revision arthroplasty for studies including all-comers and elective arthroplasty.

    30-day Mortality90-day Mortality
    Primary (%)Revision (%)Relative Risk* (95% CI)Primary (%)Revision (%)Relative Risk (95% CI)
    All-comers3,501/725,152 (0.5)28/6,777 (0.4)0.86 (0.59–1.24)2,681/415,213 (0.6)47/6,190 (0.8)1.18 (0.88–1.57)
    Elective123/18,811 (0.6)22/7,371** (0.3)0.46 (0.29–0.72)1,126/135,496 (0.8)320/13,128 (2.4)2.93 (2.59–3.31)
    • ↵* Relative risk for mortality in the revision arthroplasty with primary arthroplasty as the reference group.

    • ↵** Data from one study only, with very low mortality risk for revision arthroplasty.

    • View popup
    Table 6.

    30- and 90-day mortality rates by region.

    30-day Mortality90-day Mortality
    US/Canada (%)Other Countries (%)Relative Risk (95% CI)US/Canada (%)Other Countries (%)Relative Risk (95% CI)
    Primary hip: all-comers893/69,819 (1.28)1,331/282,889 (0.47)2.72 (2.50–2.96)37/8,885 (0.42)707/91,173 (0.78)0.54 (0.39–0.75)
    Primary knee: all-comers522/111,385 (0.43)755/261,059 (0.29)1.62 (1.45–1.81)1,733/289,094 (0.60)188/24,492 (0.77)0.78 (0.67–0.91)
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1 Jul 2011
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Early Postoperative Mortality Following Joint Arthroplasty: A Systematic Review
JASVINDER A. SINGH, JOSEPH KUNDUKULAM, DANIEL L. RIDDLE, VIBEKE STRAND, PETER TUGWELL
The Journal of Rheumatology Jul 2011, 38 (7) 1507-1513; DOI: 10.3899/jrheum.110280

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Early Postoperative Mortality Following Joint Arthroplasty: A Systematic Review
JASVINDER A. SINGH, JOSEPH KUNDUKULAM, DANIEL L. RIDDLE, VIBEKE STRAND, PETER TUGWELL
The Journal of Rheumatology Jul 2011, 38 (7) 1507-1513; DOI: 10.3899/jrheum.110280
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