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Research ArticleArticle

Association of Anti-Modified Citrullinated Vimentin with Subclinical Atherosclerosis in Early Rheumatoid Arthritis Compared with Anti-Cyclic Citrullinated Peptide

AMAL M. El-BARBARY, ELHAM M. KASSEM, MERVAT A.S. El-SERGANY, SALWA A-M. ESSA and MOHAMED A. ELTOMEY
The Journal of Rheumatology May 2011, 38 (5) 828-834; DOI: https://doi.org/10.3899/jrheum.101143
AMAL M. El-BARBARY
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  • For correspondence: ml_barbary@yahoo.com
ELHAM M. KASSEM
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MERVAT A.S. El-SERGANY
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SALWA A-M. ESSA
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MOHAMED A. ELTOMEY
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Abstract

Objective.To investigate anti-modified citrullinated vimentin (anti-MCV) in early rheumatoid arthritis (RA), including correlation with disease activity and cardiovascular risk factors, compared with anti-cyclic citrullinated peptides (anti-CCP3).

Methods.Anti-MCV and anti-CCP3 concentrations were measured in 100 patients with early RA and 100 healthy controls at baseline to determine sensitivity and specificity. Patients received methotrexate (MTX) 0.2 mg/kg/week plus prednisone 10 mg/day. Anti-MCV, anti-CCP3, rheumatoid factor (RF), Disease Activity Score for 28 joints (DAS-28), lipid profile, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein assay (hsCRP), homeostasis model assessment for insulin resistance (HOMA-IR) index, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and carotid intima-media thickness (cIMT) were measured before and after 12 months of treatment.

Results.The sensitivity and specificity for anti-MCV antibody were 75% and 90%, respectively, and for anti-CCP3 antibody 71% and 96%. Serum anti-MCV and serum anti-CCP3 levels at baseline were positively correlated with hsCRP, IL-6, HOMA-IR index, serum RF levels (p < 0.001), and cIMT (p < 0.05). Serum anti-MCV was positively correlated with serum anti-CCP3 levels. There were significant positive correlations between the percentage of changes of anti-MCV levels versus changes in DAS-28, ESR, hsCRP, atherogenic ratios (TC/HDL-C and LDL-C/HDL-C), apolipoprotein A-I, IL-6, TNF-α, HOMA-IR index, and cIMT. These correlations were not found between changes in anti-CCP3 levels compared to clinical, laboratory, and radiological variables.

Conclusion.Anti-MCV was as sensitive as anti-CCP3 in diagnosing early RA. Anti-MCV testing appears to be useful for monitoring associated subclinical atherosclerosis in early RA.

Key Indexing Terms:
  • RHEUMATOID ARTHRITIS
  • ANTI-MODIFIED CITRULLINATED VIMENTIN
  • ANTI-CYCLIC CITRULLINATED PEPTIDE
  • ATHEROSCLEROSIS
  • Accepted for publication January 11, 2011.
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The Journal of Rheumatology
Vol. 38, Issue 5
1 May 2011
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Association of Anti-Modified Citrullinated Vimentin with Subclinical Atherosclerosis in Early Rheumatoid Arthritis Compared with Anti-Cyclic Citrullinated Peptide
AMAL M. El-BARBARY, ELHAM M. KASSEM, MERVAT A.S. El-SERGANY, SALWA A-M. ESSA, MOHAMED A. ELTOMEY
The Journal of Rheumatology May 2011, 38 (5) 828-834; DOI: 10.3899/jrheum.101143

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Association of Anti-Modified Citrullinated Vimentin with Subclinical Atherosclerosis in Early Rheumatoid Arthritis Compared with Anti-Cyclic Citrullinated Peptide
AMAL M. El-BARBARY, ELHAM M. KASSEM, MERVAT A.S. El-SERGANY, SALWA A-M. ESSA, MOHAMED A. ELTOMEY
The Journal of Rheumatology May 2011, 38 (5) 828-834; DOI: 10.3899/jrheum.101143
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