Abstract
Objective. The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout.
Methods. This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene.
Results. Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22–3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively).
Conclusion. ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.
Footnotes
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Supported by the National Basic Research Program of China (2010CB534902), the National Infrastructure Program of Chinese Genetic Resources (2006DKA21300), the National Natural Science Foundation of China (30570890), and the National Natural Science and Foundation of China (30871192).
- Accepted for publication September 10, 2010.