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Research ArticleArticle

Minimally Important Difference of Health Assessment Questionnaire in Psoriatic Arthritis: Relating Thresholds of Improvement in Functional Ability to Patient-rated Importance and Satisfaction

PHILIP J. MEASE, J. MICHAEL WOOLLEY, BOJENA BITMAN, BRIAN C. WANG, DENISE R. GLOBE and AMITABH SINGH
The Journal of Rheumatology November 2011, 38 (11) 2461-2465; DOI: https://doi.org/10.3899/jrheum.110546
PHILIP J. MEASE
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  • For correspondence: pmease@nwlink.com
J. MICHAEL WOOLLEY
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BOJENA BITMAN
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BRIAN C. WANG
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DENISE R. GLOBE
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AMITABH SINGH
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Abstract

Objective. To evaluate changes in function as measured by Health Assessment Questionnaire Disability Index (HAQ-DI) and the meaningfulness of the changes, in importance and satisfaction, in patients with psoriatic arthritis (PsA).

Methods. HAQ-DI was assessed at baseline and at Weeks 4, 12, and 24 in a randomized double-blind study of 205 patients with active PsA receiving etanercept 25 mg twice weekly or placebo. Concurrently, patients rated the importance of and satisfaction with their change in function on a 7-point scale (1 = not at all important/satisfied; 7 = extremely important/satisfied). Mean HAQ-DI improvement corresponding to ratings of minimally (2–3) or very (6–7) important or satisfied was determined using a posthoc linear mixed-model analysis. Patient importance ratings were used as an anchor to estimate minimally important difference (MID) for HAQ-DI; distribution-based estimates were also calculated.

Results. A total of 161 patients (69 placebo; 92 etanercept) had ≥ 1 HAQ-DI scores showing improvement from baseline and a corresponding importance or satisfaction rating. HAQ-DI improvements corresponding to importance scale ratings of 2 or 3 were 0.335 (95% CI 0.214, 0.455) and 0.360 (95% CI 0.263, 0.456), respectively, suggesting an MID of about 0.35. HAQ-DI improvements corresponding to satisfaction scale ratings of 2 and 3 were 0.293 (95% CI 0.230, 0.357) and 0.360 (95% CI 0.307, 0.413). For a given change in HAQ-DI, nearly two-thirds of patients indicated a lower rating for satisfaction than for importance. This trial was registered in the ClinicalTrials.gov registry (NCT00317499).

Conclusion. Our study suggests the MID for HAQ-DI in PsA is about 0.35. The results may also provide insight into patient satisfaction with changes in function and expectations for therapy.

Key Indexing Terms:
  • PSORIATIC ARTHRITIS
  • PATIENT SATISFACTION
  • DISABILITY
  • HEALTH ASSESSMENT QUESTIONNAIRE
  • OUTCOME ASSESSMENT

Psoriatic arthritis (PsA) is a complex and multifaceted chronic inflammatory disease. PsA may manifest with involvement of the peripheral and axial joints, skin, and nails, and enthesitis and dactylitis with variability in disease course and severity of symptoms. The goals of treatment are to alleviate disease signs and symptoms, inhibit structural damage of the joints, and maximize patient function and quality of life1,2.

In contrast to rheumatoid arthritis (RA), for which disease response criteria are well defined, composite responder indices are still being developed in PsA. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) and OMERACT (Outcome Measures in Rheumatology Clinical Trials) are making progress in this area and have recently identified several core domains for evaluating treatment response in patients with PsA3,4. One of these core domains is patient functional status. The Health Assessment Questionnaire Disability Index (HAQ-DI)5 is validated in RA and is an accepted instrument for evaluating function in PsA4,6. Loss of function as assessed by HAQ-DI has been associated with a poor prognosis in patients with PsA1.

For outcome measures to be of use in the clinic, physicians must have reliable benchmarks for evaluating them. To aid in interpretation, changes in outcome measures can be anchored by clinical markers or by patient perception. A common benchmark for evaluating changes is the minimally important difference (MID), which is generally considered to be the smallest change that has been defined in some way to be clinically important7,8. It is also relevant to consider the levels of change that are very important to patients or that minimally or greatly improve patient satisfaction. For measures of functional status such as HAQ-DI, the patients’ perspective of the relevance of change may be a key component of the interpretation.

We have previously presented a preliminary estimate of the minimally important difference of HAQ-DI in PsA using data from a 24-week double-blind, randomized, placebo-controlled study of etanercept in patients with active PsA9. The goal of the current report is to expand on that analysis to help to interpret changes in the HAQ and the meaningfulness of these changes, in terms of importance and satisfaction, to patients with PsA.

Materials and Methods

This trial, registered in ClinicalTrials.gov, identifier NCT00317499, was a double-blind, placebo-controlled, phase 3 study in patients with PsA. The study design and primary clinical and radiographic results have been described10,11. Briefly, patients between 18 and 70 years of age were eligible if they had active PsA inadequately responding to therapy. Patients had ≥ 3 swollen joints and ≥ 3 tender joints as well as a qualifying target lesion of stable plaque psoriasis. Patients receiving stable methotrexate (MTX) therapy for at least 2 months were eligible and could continue MTX at a stable dose of ≤ 25 mg/week. Patients were randomly assigned to receive etanercept 25 mg twice weekly as a self-administered subcutaneous injection or matching placebo for 24 weeks.

The study was conducted in accord with the International Conference on Harmonization Good Clinical Practice guidelines. Institutional review boards for each study center approved the study protocol and all patients provided written informed consent before any study-related procedures were performed.

Patient-reported outcomes including the HAQ-DI were measured at baseline and at 4, 12, and 24 weeks12. HAQ-DI is a commonly used measure of physical function that is based on patient-reported assessment of ability to perform tasks related to daily living. The HAQ-DI score is a continuous variable that ranges from 0 (no difficulty) to 3 (unable to perform)5. Concurrently, patients were asked to rate the importance of their improvement in functioning and their satisfaction with their improvement in functioning, each on a 7-point scale, with text anchors only at 1 (labeled not at all important/satisfied) and 7 (labeled extremely important/satisfied). Patients who had at least 1 HAQ-DI score that indicated improvement in functioning were included in the analysis. The analysis modifies and expands on a previously reported preliminary analysis of HAQ-DI in these patients9.

Both anchor-based and distribution-based methods13,14,15,16 were used to assist in interpreting changes in the HAQ-DI scores and to assess MID.

Anchor-based method

For the scales measuring importance/satisfaction with change, since changes scored at 1 point were labeled not at all important/satisfied, patient ratings of 2 to 3 were interpreted as being just above not important/satisfied and were assumed to indicate changes that are minimally important/satisfactory. Ratings of 6 to 7 were interpreted as indicating very important difference. The changes in HAQ-DI scores associated with these levels of importance and satisfaction (anchors) were determined using a repeated measures mixed-model analysis. The covariance structure was modeled as “unstructured,” which does not assume any correlation pattern between the repeated measures.

Distribution-based method

Various distribution-based methods have been proposed for estimating MID, including a half standard deviation of the mean change13, and 1.96 times the standard error of measurement (SEMT)17. The SEMT for the HAQ was calculated as described by Beaton, et al8: SEMT=∂baseline HAQ1−rbaseline HAQ where ∂ = standard deviation, r = Cronbach’s alpha reliability coefficient. In this calculation, the estimated reliability coefficient was calculated using data from all 20 HAQ items without aids and devices. All statistical analyses were performed using SAS version 9.1 (SAS Institute, Cary, NC, USA).

RESULTS

Demographic data

A total of 205 patients (104 placebo, 101 etanercept) enrolled in the study. Of the enrolled patients, 161 (69 placebo, 92 etanercept) had at least 1 HAQ-DI score that showed improvement from baseline (i.e., a decreased score) and a corresponding response indicating their perception of the level of importance and/or satisfaction associated with the change in function, and thus were included in this analysis.

Baseline demographics and disease characteristics for patients included in the analysis were similar to those of the overall population (Table 1)18. Fewer placebo patients were included because of the criterion of HAQ-DI improvement from baseline, and a slightly smaller percentage of patients were men (48% in this analysis vs 51% in the overall population). The mean age of subjects was 47 years and mean disease duration was 9.1 years. The mean HAQ score at baseline was 1.2 (range 0.13–2.88) among these patients compared with a mean HAQ-DI score of 1.1 (range 0.00–2.88) for the overall population.

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Table 1.

Baseline demographics and disease characteristics of a subset of patients in a randomized, double-blind, placebo-controlled trial of etanercept in patients with psoriatic arthritis. The table includes patients with at least 1 HAQ-DI score showing improvement from baseline.

Changes in HAQ associated with importance and satisfaction

We analyzed the relationship between changes in the HAQ-DI score and patients’ perception of the importance of those changes, as indicated on a 7-point scale. The mean change in HAQ-DI that corresponded to each rating on the importance scale as determined from a linear mixed model is shown in Table 2. Patient ratings of minimally important improvement (levels 2 to 3) corresponded to estimated improvements of 0.335 (95% CI 0.214, 0.455) for level 2 and 0.360 (95% CI 0.263, 0.456) for level 3. Combining these estimates leads to an estimate for the MID of 0.348 (the calculated estimate for a change in the importance item of 2.5), which we rounded to 0.35, but the number of responses in the 2 to 3 point range was small (n = 11). Patient ratings indicating very important improvement (levels 6 to 7; n = 291) corresponded to HAQ-DI improvements of 0.435 (95% CI 0.385, 0.485) to 0.460 (95% CI 0.404, 0.515) for 6 and 7-point changes, respectively.

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Table 2.

HAQ-DI improvements associated with patient ratings of importance. Linearly predicted HAQ-DI improvement was calculated using a mixed model that accounts for within-patient variation over time by patient response as to level of importance of changes; post-baseline patient responses were collected at 4, 12, and 24 weeks. In the patient rating scale for importance of change in function, 1 = not at all important and 7 = extremely important.

Similarly, we analyzed the relationship between changes in the HAQ-DI score and patient satisfaction with those changes (Table 3). Patient satisfaction ratings of 2 to 3 (n = 83 responses) corresponded to mean improvements in HAQ-DI of 0.293 (95% CI 0.230, 0.357) to 0.360 (95% CI 0.307, 0.413). Satisfaction ratings of 6 to 7 (n = 157) corresponded to mean improvements in HAQ-DI of 0.559 to 0.625.

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Table 3.

HAQ-DI improvements associated with patient ratings of satisfaction. Linearly predicted HAQ-DI improvement was calculated using a mixed model that accounts for within-patient variation over time by patient response as to level of satisfaction with changes; post-baseline patient responses were collected at 4, 12, and 24 weeks. In the patient rating scale for importance of change in function, 1 = not at all important and 7 = extremely important.

Distribution-based estimates of MID for HAQ-DI were also evaluated and provided values similar to the estimates obtained using the anchor-based method (Table 4). Using a half SD estimate for importance gave a HAQ-DI change value of 0.293, while using 1.96-times the SEMT gave an estimate of 0.266.

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Table 4.

Minimal important differences in HAQ-DI as determined by distribution-based methods.

Relationship between patient perception of importance and satisfaction

The relationship between the importance patients assigned to their improvement in function and their satisfaction with that improvement was also evaluated (Table 5). As noted above, only 11 of 388 responses to the importance of change in function were scored in the 2 to 3 point range. The vast majority of responses regarding importance of change were in the 6 to 7 point range. Satisfaction ratings associated with change in function were somewhat more evenly distributed across the scale. In 63% of responses, patients rated their level of satisfaction with the change lower than they rated the level of importance of that change.

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Table 5.

Relationship of patient importance and patient satisfaction ratings. The top number in each table cell is the frequency of each pair of satisfaction/importance ratings; the bottom number is the percentage of all pairs of ratings represented by that satisfaction/importance pair.

DISCUSSION

Our study examined patient ratings of importance and satisfaction associated with changes in HAQ-DI over 24 weeks as part of a randomized clinical trial of etanercept in patients with active psoriatic arthritis11. The improvement in HAQ-DI score that was associated with minimal importance was 0.35 using anchor-based methods. The small number of subjects reporting change of small importance led to somewhat wide estimated CI around this estimate. These estimates were similar to estimates using distribution-based methods for determining MID. Minimal satisfaction was associated with a similar change in HAQ-DI of about 0.33.

The MID for HAQ-DI in RA is accepted to be on the order of 0.2219,20,21 (absolute value), and in ankylosing spondylitis the MID for improvement and worsening in HAQ-DI were recently estimated to be −0.136 and 0.22022. We previously published a preliminary report estimating an MID of 0.3 for the HAQ in PsA using patient data from the trial examined here9. The original estimate was calculated by using patient ratings of satisfaction with change, rather than importance of change, because of the much larger number of responses available in the 2- to 3-point range of the scale for patient satisfaction compared with importance. Because MID is more appropriately calculated with importance data than with satisfaction data, we believe the updated MID estimate of 0.35 reported here provides a more suitable estimation of MID in patients with PsA. Our value is somewhat higher than a recently reported MID estimate of 0.131 that was based on a group of almost 250 patients with PsA at a single clinic using methods based on an overall health status anchor23. Patients in that study had less functional disability at baseline (mean HAQ-DI = 0.732) than the patients in our study (mean HAQ-DI = 1.16), which may have contributed to the difference.

One of the goals of estimating the MID is to define a threshold for responder analyses. With 8 response categories for the HAQ-DI, changes would occur in increments of one-eighth (0.125) of a point. This implies that for responder analyses, changes in the HAQ-DI in the range of 0.250 to 0.375 are in essence the same, and the MID is likely in this range. Therefore responder analyses using a threshold of 0.375 may be appropriate for the HAQ-DI in PsA.

Recently in the literature, researchers have begun to explore the concept of “really important changes” as a complement to understanding minimally important changes. For example, a really important change in HAQ-DI in patients with RA was estimated to be in the range of 0.75 to 0.87 in 1 study24. In the present study in patients with PsA, change in HAQ-DI associated with very important improvement in function was about 0.45, a lower value than we expected. However, change in HAQ-DI associated with a very high level of satisfaction was higher, about 0.59. It appears that while patients may find the changes they experience to be important, they are less likely to be satisfied with them.

Our study had several limitations. The number of patient responses rating their functional change as of little importance was small, necessitating the use of a linear model to determine MID. However, given that multiple methods — anchor-based and distribution-based — identified a similar range for MID, we believe our estimates are meaningful. Also, we examined only ratings associated with improvements in HAQ-DI. There is considerable debate about whether MID should be evaluated using both positive and negative changes in outcome measures. In some cases, MID has been shown to be different for improvements vs declines in function22. Thus, our estimates should only be used to evaluate improvements in HAQ-DI. Additionally, MID estimates may depend on baseline status of the patients studied. The patients in this trial had active PsA and a mean baseline HAQ-DI score of 1.1, considered moderate functional impairment, and so the MID may need to be interpreted in this context.

Our study examined thresholds of change in HAQ-DI that corresponded to patient perceptions of the importance of and their satisfaction with those changes. A HAQ-DI improvement of about 0.35 appears to be a minimally important change, while 0.45 could be considered very important. Our study may provide insight into patient perceptions of changes in function and their expectations with regard to therapy.

Acknowledgment

Holly Brenza Zoog, PhD, of Amgen Inc. provided medical writing support for this article.

Footnotes

  • Supported by Immunex Corporation, a wholly owned subsidiary of Amgen Inc., and by Wyeth, which was acquired by Pfizer Inc. in October 2009.

  • Accepted for publication June 29, 2011.

REFERENCES

  1. 1.↵
    1. Ritchlin CT,
    2. Kavanaugh A,
    3. Gladman DD,
    4. Mease PJ,
    5. Helliwell P,
    6. Boehncke WH,
    7. et al.
    Treatment recommendations for psoriatic arthritis. Ann Rheum Dis 2009;68:1387–94.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Gottlieb A,
    2. Korman NJ,
    3. Gordon KB,
    4. Feldman SR,
    5. Lebwohl M,
    6. Koo JY,
    7. et al.
    Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. J Am Acad Dermatol 2008;58:851–64.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Gladman DD,
    2. Landewe R,
    3. McHugh NJ,
    4. Fitzgerald O,
    5. Thaci D,
    6. Coates L,
    7. et al.
    Composite measures in psoriatic arthritis: GRAPPA 2008. J Rheumatol 2010;37:453–61.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Mease PJ
    . Assessment tools in psoriatic arthritis. J Rheumatol 2008;35:1426–30.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Stanford University Medical Center
    . ARAMIS: HAQ. [Internet. Accessed July 22, 2011.] Available from: http://aramis.stanford.edu/HAQ.html
  6. 6.↵
    1. Mease PJ,
    2. Antoni CE,
    3. Gladman DD,
    4. Taylor WJ
    . Psoriatic arthritis assessment tools in clinical trials. Ann Rheum Dis 2005;64 Suppl 2:ii49–54.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Beaton DE,
    2. Boers M,
    3. Wells GA
    . Many faces of the minimal clinically important difference (MCID): a literature review and directions for future research. Curr Opin Rheumatol 2002; 14:109–14.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Beaton DE,
    2. Bombardier C,
    3. Katz JN,
    4. Wright JG,
    5. Wells G,
    6. Boers M,
    7. et al.
    Looking for important change/differences in studies of responsiveness. OMERACT MCID Working Group. Outcome Measures in Rheumatology. Minimal clinically important difference. J Rheumatol 2001;28:400–5.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Mease PJ,
    2. Ganguly R,
    3. Wanke L,
    4. Yu E,
    5. Singh A
    . How much improvement in functional status is considered important by patients with active psoriatic arthritis: applying the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) group guidelines [abstract]. Ann Rheum Dis 2004;63 Suppl 1:SAT0015.
    OpenUrl
  10. 10.↵
    1. Mease PJ,
    2. Kivitz AJ,
    3. Burch FX,
    4. Siegel EL,
    5. Cohen SB,
    6. Ory P,
    7. et al.
    Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept. J Rheumatol 2006;33:712–21.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Mease PJ,
    2. Goffe BS,
    3. Metz J,
    4. VanderStoep A,
    5. Finck B,
    6. Burge DJ
    . Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 2000;356:385–90.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Mease PJ,
    2. Woolley JM,
    3. Singh A,
    4. Tsuji W,
    5. Dunn M,
    6. Chiou C-F
    . Patient-reported outcomes in a randomized trial of etanercept in psoriatic arthritis. J Rheumatol 2010;37:1221–7.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Norman GR,
    2. Sloan JA,
    3. Wyrwich KW
    . Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care 2003;41:582–92.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Revicki D,
    2. Hays RD,
    3. Cella D,
    4. Sloan J
    . Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. J Clin Epidemiol 2008;61:102–9.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Wyrwich KW,
    2. Nienaber NA,
    3. Tierney WM,
    4. Wolinsky FD
    . Linking clinical relevance and statistical significance in evaluating intra-individual changes in health-related quality of life. Med Care 1999;37:469–78.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Hays RD,
    2. Woolley JM
    . The concept of clinically meaningful difference in health-related quality-of-life research. How meaningful is it? Pharmacoeconomics 2000;18:419–23.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Ware JE Jr.,
    2. Bayliss MS,
    3. Rogers WH,
    4. Kosinski M,
    5. Tarlov AR
    . Differences in 4-year health outcomes for elderly and poor, chronically ill patients treated in HMO and fee-for-service systems. Results from the Medical Outcomes Study. JAMA 1996; 276:1039–47.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Mease PJ,
    2. Kivitz AJ,
    3. Burch FX,
    4. Siegel EL,
    5. Cohen SB,
    6. Ory P,
    7. et al.
    Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression. Arthritis Rheum 2004;50:2264–72.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Redelmeier DA,
    2. Lorig K
    . Assessing the clinical importance of symptomatic improvements. An illustration in rheumatology. Arch Intern Med 1993;153:1337–42.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Kosinski M,
    2. Zhao SZ,
    3. Dedhiya S,
    4. Osterhaus JT,
    5. Ware JE Jr.
    . Determining minimally important changes in generic and disease-specific health-related quality of life questionnaires in clinical trials of rheumatoid arthritis. Arthritis Rheum 2000;43:1478–87.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Wells GA,
    2. Tugwell P,
    3. Kraag GR,
    4. Baker PR,
    5. Groh J,
    6. Redelmeier DA
    . Minimum important difference between patients with rheumatoid arthritis: the patient’s perspective. J Rheumatol 1993;20:557–60.
    OpenUrlPubMed
  22. 22.↵
    1. Wheaton L,
    2. Pope J
    . The minimally important difference for patient-reported outcomes in spondyloarthropathies including pain, fatigue, sleep, and Health Assessment Questionnaire. J Rheumatol 2010;37:816–22.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Kwok T,
    2. Pope JE
    . Minimally important difference for patient-reported outcomes in psoriatic arthritis: Health Assessment Questionnaire and pain, fatigue, and global visual analog scales. J Rheumatol 2010;37:1024–8.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Wolfe F,
    2. Michaud K,
    3. Strand V
    . Expanding the definition of clinical differences: From minimally clinically important differences to really important differences. Analyses in 8931 patients with rheumatoid arthritis. J Rheumatol 2005;32:583–9.
    OpenUrlAbstract/FREE Full Text
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Minimally Important Difference of Health Assessment Questionnaire in Psoriatic Arthritis: Relating Thresholds of Improvement in Functional Ability to Patient-rated Importance and Satisfaction
PHILIP J. MEASE, J. MICHAEL WOOLLEY, BOJENA BITMAN, BRIAN C. WANG, DENISE R. GLOBE, AMITABH SINGH
The Journal of Rheumatology Nov 2011, 38 (11) 2461-2465; DOI: 10.3899/jrheum.110546

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Minimally Important Difference of Health Assessment Questionnaire in Psoriatic Arthritis: Relating Thresholds of Improvement in Functional Ability to Patient-rated Importance and Satisfaction
PHILIP J. MEASE, J. MICHAEL WOOLLEY, BOJENA BITMAN, BRIAN C. WANG, DENISE R. GLOBE, AMITABH SINGH
The Journal of Rheumatology Nov 2011, 38 (11) 2461-2465; DOI: 10.3899/jrheum.110546
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The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
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