Article Figures & Data
Tables
- Table 1.
Summaries for 24-week changes from baseline for the various measures. (D_ denotes differences between current and baseline values).
Training Difference Data Mean (SE) t-value Unadjusted Z-value for Effect Size SRM GES GUES OR OR (change from baseline) Placebo Drug Drug vs Placebo Drug vs Placebo Drug vs Placebo Placebo Drug Placebo Drug Drug vs Placebo D_TJC68 −4.066 (0.824) −10.693 (0.835) −5.64 0.955 −5.19 −0.2594 −0.7661 −0.3390 −0.8430 −0.5362 −0.8914 D_SJC66 −2.854 (0.572) −6.368 (0.548) −4.44 0.946 −4.17 −0.2800 −0.6793 −0.3429 −0.7644 −0.4220 −0.7651 D_HAQ −0.118 (0.029) −0.477 (0.034) −7.95 0.183 −6.88 −0.2178 −0.7462 −0.2859 −0.9162 −0.7583 −1.1519 D_CRP −0.043 (0.104) −1.281 (0.158) −6.44 0.611 −5.79 −0.0662 −0.5263 −0.0286 −0.5370 −0.6155 −0.8523 D_logCRP −0.075 (0.058) −1.393 (0.087) −12.44 0.315 −9.15 −0.0992 −1.0721 −0.0893 −1.0652 −1.1894 −1.6600 D_MDGDA (Likert) −0.333 (0.065) −1.329 (0.069) −10.37 0.360 −8.37 −0.5023 −1.8403 −0.3546 −1.2689 −0.9983 −1.4138 D_PtGDA (Likert) −0.081 (0.068) −1.069 (0.077) −9.55 0.426 −7.99 −0.1123 −1.1643 −0.0810 −0.9168 −0.9090 −1.0753 D_Patient assessment of pain (Likert) −0.109 (0.071) −1.165 (0.081) −9.72 0.435 −8.07 −0.1708 −1.3199 −0.1059 −0.9443 −0.9255 −1.1313 D_SF-36PCS* 1.544 (0.621) 9.636 (0.672) 8.82 1.096 7.47 0.1573 0.9688 0.1712 0.9618 0.8478 1.0685 D_SF-36 MCS* 0.317 (0.763) 2.492 (0.656) 2.31 1.023 2.29 0.0983 0.2220 0.0324 0.2551 0.2225 0.2548 -
↵* Improvement over time is indicated by a positive increase in the score, as compared to the other measures where a decrease indicated improvement. SRM: Standardized response mean; GES: group effect size; GUES: Guyatt’s effect size; TJC: tender joint counts; SJC: swollen joint counts; HAQ: Health Assessment Questionnaire; CRP: C-reactive protein; MDGDA: physician global assessment of disease activity; P+GDA: patient global assessment of disease activity; SF-36 PCS: Medical Outcomes Study Short-Form physical component; SF-36 MCS: SF-36 mental component.
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Loadings Factor 1 Factor 2 Factor 3 Factor 4 Factor 5 D_SJC66 0.139 0 0.733 0 0 D_TJC68 0.209 0.228 0.632 0.182 0 D_CRP 0.183 0.115 0 0.520 0.101 D_MDGDA 0.490 0.129 0.249 0.367 0 D_PtGDA 0.860 0.195 0.220 0.150 0.169 D_patient assessment of pain 0.744 0.233 0.176 0.262 0.127 D_HAQ 0.313 0.868 0.225 0.214 0.219 D_SF-36PCS −0.586 −0.528 −0.225 −0.220 0.523 D_SF-36MCS −0.159 −0.133 −0.136 −0.153 −0.407 Percentage of the variance explained by latent factors 23.3 13.6 13.3 7.2 6.1 Cumulative percentage 23.3 36.9 50.2 57.4 63.6 -
For abbreviations see Table 1. Bold type indicates significant loading.
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Domain Model Estimate SE z-value p Intercept 0.6935 0.1898 3.65 0.0003 C_TJC68 −0.0212 0.0083 −2.55 0.0108 D_CRP −0.8936 0.1791 −4.99 < 0.0001 BL_CRP −0.6061 0.1452 −4.17 < 0.0001 MAX.SUBJ.ASSESS −0.9679 0.1625 −5.96 < 0.0001 -
C_ denotes current; D_ denotes difference; BL_ denotes baseline; MAX.SUBJ.ASSESS: max (D_MDGDA, D_PtGDA, D_patient assessment of pain, 5/3.D_HAQ). For abbreviations see Table 1.
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Percentage Change Model Estimate SE z-value p Intercept −0.8958 0.1629 −5.50 < 0.0001 PC_TJC68 −0.5290 0.2313 −2.29 0.0222 PC_CRP −0.3298 0.1430 −2.31 0.0211 PC_MDGDA −1.6310 0.4155 −3.93 < 0.0001 PC_Patient assessment of change −0.7936 0.3577 −2.22 0.0265 PC_HAQ −0.6349 0.2787 −2.28 0.0227 -
PC_ denotes percentage change. For abbreviations see Table 1.
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