Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleArticle

Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population

MIRKO MANETTI, LIDIA IBBA-MANNESCHI, CINZIA FATINI, SERENA GUIDUCCI, GIOVANNA CUOMO, CLAUDIA BONINO, LAURA BAZZICHI, VASILIKI LIAKOULI, ROBERTO GIACOMELLI, ROSANNA ABBATE, STEFANO BOMBARDIERI, CARLOMAURIZIO MONTECUCCO, GABRIELE VALENTINI and MARCO MATUCCI-CERINIC
The Journal of Rheumatology September 2010, 37 (9) 1852-1857; DOI: https://doi.org/10.3899/jrheum.100237
MIRKO MANETTI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mirkomanetti@yahoo.it
LIDIA IBBA-MANNESCHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CINZIA FATINI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SERENA GUIDUCCI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GIOVANNA CUOMO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CLAUDIA BONINO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
LAURA BAZZICHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
VASILIKI LIAKOULI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ROBERTO GIACOMELLI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ROSANNA ABBATE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
STEFANO BOMBARDIERI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CARLOMAURIZIO MONTECUCCO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GABRIELE VALENTINI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MARCO MATUCCI-CERINIC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

REFERENCES

  1. 1.↵
    1. Varga J,
    2. Abraham D
    . Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007;117:557–67.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Agarwal SK,
    2. Tan FK,
    3. Arnett FC
    . Genetics and genomic studies in scleroderma (systemic sclerosis). Rheum Dis Clin North Am 2008;34:17–40.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Granel B,
    2. Bernard F,
    3. Chevillard C
    . Genetic susceptibility to systemic sclerosis: from clinical aspect to genetic factor analyses. Eur J Intern Med 2009;20:242–52.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Hesselstrand R,
    2. Scheja A,
    3. Akesson A
    . Mortality and causes of death in a Swedish series of systemic sclerosis patients. Ann Rheum Dis 1998;57:682–6.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Varga J,
    2. Bashey RI
    . Regulation of connective tissue synthesis in systemic sclerosis. Int Rev Immunol 1995;12:187–99.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Wynn TA
    . Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007;117:524–9.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Pardo A,
    2. Selman M
    . Matrix metalloproteases in aberrant fibrotic tissue remodeling. Proc Am Thorac Soc 2006;3:383–8.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Lagente V,
    2. Le Quement C,
    3. Boichot E
    . Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases. Expert Opin Ther Targets 2009;13:287–95.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Kang HR,
    2. Cho SJ,
    3. Lee CG,
    4. Homer RJ,
    5. Elias JA
    . Transforming growth factor (TGF)-beta 1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem 2007;282:7723–32.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Matute-Bello G,
    2. Wurfel MM,
    3. Lee JS,
    4. Park DR,
    5. Frevert CW,
    6. Madtes DK,
    7. et al.
    Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol 2007;37:210–21.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Serratì S,
    2. Cinelli M,
    3. Margheri F,
    4. Guiducci S,
    5. Del Rosso A,
    6. Pucci M,
    7. et al.
    Systemic sclerosis fibroblasts inhibit in vitro angiogenesis by MMP-12-dependent cleavage of the endothelial cell urokinase receptor. J Pathol 2006;210:240–8.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Jormsjo S,
    2. Ye S,
    3. Moritz J,
    4. Walter DH,
    5. Dimmeler S,
    6. Zeiher AM,
    7. et al.
    Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease. Circ Res 2000;86:998–1003.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. Hunninghake GM,
    2. Cho MH,
    3. Tesfaigzi Y,
    4. Soto-Quiros ME,
    5. Avila L,
    6. Lasky-Su J,
    7. et al.
    MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361:2599–608.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. LeRoy EC,
    2. Black C,
    3. Fleischmajer R,
    4. Jablonska S,
    5. Krieg T,
    6. Medsger TA Jr.,
    7. et al.
    Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202–5.
    OpenUrlPubMed
  15. 15.↵
    1. Liakouli V,
    2. Manetti M,
    3. Pacini A,
    4. Tolusso B,
    5. Fatini C,
    6. Toscano A,
    7. et al.
    The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis. Ann Rheum Dis 2009;68:584–90.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Manetti M,
    2. Liakouli V,
    3. Fatini C,
    4. Cipriani P,
    5. Bonino C,
    6. Vettori S,
    7. et al.
    Association between a stromal cell-derived factor 1 (SDF-1/CXCL12) gene polymorphism and microvascular disease in systemic sclerosis. Ann Rheum Dis 2009;68:408–11.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Woo M,
    2. Park K,
    3. Nam J,
    4. Kim JC
    . Clinical implications of matrix metalloproteinase-1, -3, -7, -9, -12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer. J Gastroenterol Hepatol 2007;22:1064–70.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Sternlicht MD,
    2. Werb Z
    . How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463–516.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Ye S
    . Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol 2000;19:623–9.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Wipff J,
    2. Dieude P,
    3. Avouac J,
    4. Tiev K,
    5. Hachulla E,
    6. Cracowski JL,
    7. et al.
    Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population. J Rheumatol 2010;37:599–602.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Garbacki N,
    2. Di Valentin E,
    3. Piette J,
    4. Cataldo D,
    5. Crahay C,
    6. Colige A
    . Matrix metalloproteinase 12 silencing: a therapeutic approach to treat pathological lung tissue remodeling? Pulm Pharmacol Ther 2009;22:267–78.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Demedts IK,
    2. Morel-Montero A,
    3. Lebecque S,
    4. Pacheco Y,
    5. Cataldo D,
    6. Joos GF,
    7. et al.
    Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006;61:196–201.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Sato M,
    2. Hirayama S,
    3. Lara-Guerra H,
    4. Anraku M,
    5. Waddell TK,
    6. Liu M,
    7. et al.
    MMP-dependent migration of extrapulmonary myofibroblast progenitors contributing to posttransplant airway fibrosis in the lung. Am J Transplant 2009;9:1027–36.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 37, Issue 9
1 Sep 2010
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population
MIRKO MANETTI, LIDIA IBBA-MANNESCHI, CINZIA FATINI, SERENA GUIDUCCI, GIOVANNA CUOMO, CLAUDIA BONINO, LAURA BAZZICHI, VASILIKI LIAKOULI, ROBERTO GIACOMELLI, ROSANNA ABBATE, STEFANO BOMBARDIERI, CARLOMAURIZIO MONTECUCCO, GABRIELE VALENTINI, MARCO MATUCCI-CERINIC
The Journal of Rheumatology Sep 2010, 37 (9) 1852-1857; DOI: 10.3899/jrheum.100237

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population
MIRKO MANETTI, LIDIA IBBA-MANNESCHI, CINZIA FATINI, SERENA GUIDUCCI, GIOVANNA CUOMO, CLAUDIA BONINO, LAURA BAZZICHI, VASILIKI LIAKOULI, ROBERTO GIACOMELLI, ROSANNA ABBATE, STEFANO BOMBARDIERI, CARLOMAURIZIO MONTECUCCO, GABRIELE VALENTINI, MARCO MATUCCI-CERINIC
The Journal of Rheumatology Sep 2010, 37 (9) 1852-1857; DOI: 10.3899/jrheum.100237
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Vasculitis: What Have We Learned in the Last 50 Years?
  • Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis (RA)–associated Bronchiectasis: Role of RA-related Autoantibodies
  • Effectiveness of 6-month Use of Secukinumab in Patients With Psoriatic Arthritis in the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
Show more Articles

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire