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Research ArticleArticle

Estimated Cutoff Points for the 28-Joint Disease Activity Score Based on C-reactive Protein in a Longitudinal Register of Early Arthritis

ISABEL CASTREJÓN, ANA M. ORTIZ, ESTHER TOLEDANO, SANTOS CASTAÑEDA, ALBERTO GARCÍA-VADILLO, ESTHER PATIÑO and ISIDORO GONZÁLEZ-ÁLVARO
The Journal of Rheumatology July 2010, 37 (7) 1439-1443; DOI: https://doi.org/10.3899/jrheum.091333
ISABEL CASTREJÓN
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ANA M. ORTIZ
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ESTHER TOLEDANO
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SANTOS CASTAÑEDA
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ALBERTO GARCÍA-VADILLO
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ESTHER PATIÑO
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ISIDORO GONZÁLEZ-ÁLVARO
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  • For correspondence: isidoro.ga@ser.es
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    Figure 1.

    DAS28-CRP discriminated the disease activity state better than the DAS28-ESR. The “roccomp” command of Stata was used to establish whether there were significant differences between the areas under the receiver operating characteristic (ROC) curves of DAS28-CRP (lower panels) or DAS28-ESR (upper panels).

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    Figure 2.

    DAS28-CRP better discriminates the minimal disease activity versus DAS28-ESR. We used the “roccomp” command of Stata to determine whether the areas under the receiver operating characteristic (ROC) curves of DAS28-CRP (right panel) or DAS28-ESR (left panel) were significantly different.

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    Table 1.

    Patient visits in agreement or disagreement with the overall disease activity assessment.

    RemissionLow ActivityModerate ActivityHigh Activityn
    Visits in agreement, no. (%)91 (87.5)266 (92)80 (63.5)39 (79.6)476
    Visits in disagreement, no. (%)13 (12.5)23 (8)46 (36.5)10 (20.4)92
    Total10428912649568
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    Table 2.

    Variables associated with disagreement in the multivariate analysis.

    VariablesModel 1Model 2
    OR (95% CI)pOR (95% CI)p
    Female gender0.72 (0.41–1.27)0.270.64 (0.37–1.10)0.10
    Age—NS—NS
    Patient global disease activity0.99 (0.98–1.01)0.280.99 (0.98–1)0.17
    Swollen joint count—NS—NS
    Tender joint count1.04 (0.99–1.09)0.061.05 (1–1.10)0.02
    Health Assessment Questionnaire—NS1.80 (1.11–2.94)0.02
    Erythrocyte sedimentation rate—NS—NS
    C-reactive protein—NS—NS
    Disease activity state by consensus
      RemissionReference—
      Low0.600.19NINI
      Moderate3.77< 0.01
      High1.530.46
    • NS: not significant; NI: not included.

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The Journal of Rheumatology
Vol. 37, Issue 7
1 Jul 2010
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Estimated Cutoff Points for the 28-Joint Disease Activity Score Based on C-reactive Protein in a Longitudinal Register of Early Arthritis
ISABEL CASTREJÓN, ANA M. ORTIZ, ESTHER TOLEDANO, SANTOS CASTAÑEDA, ALBERTO GARCÍA-VADILLO, ESTHER PATIÑO, ISIDORO GONZÁLEZ-ÁLVARO
The Journal of Rheumatology Jul 2010, 37 (7) 1439-1443; DOI: 10.3899/jrheum.091333

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Estimated Cutoff Points for the 28-Joint Disease Activity Score Based on C-reactive Protein in a Longitudinal Register of Early Arthritis
ISABEL CASTREJÓN, ANA M. ORTIZ, ESTHER TOLEDANO, SANTOS CASTAÑEDA, ALBERTO GARCÍA-VADILLO, ESTHER PATIÑO, ISIDORO GONZÁLEZ-ÁLVARO
The Journal of Rheumatology Jul 2010, 37 (7) 1439-1443; DOI: 10.3899/jrheum.091333
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