Lack of Interaction Between Systemic Lupus Erythematosus-associated Polymorphisms in TYK2 and IRF5

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Table 1.

Lack of epistatic interaction between the SLE-associated SNP in TYK2 and IRF5.

	SNP		No. of Subjects		Models with or without Interaction*		LRASSOC Models **
	TYK2	IRF5	SLE	Controls	Best Model	p	Best Model	AIC to Interaction
Hellquist²	rs2304256	rs10954213	277	356	With interaction	0.014	–	–
Our data^3,8	rs2304256	rs10954213	419	454	No difference	0.68	Additive†	1.83
	rs2304256	rs10488631	1223	1300	No difference	0.3	Additive	1.98
	rs2304256	rs729302	1223	1300	No difference	0.88	Additive	0.94

↵* Multivariate logistic regression models with and without an interaction term were compared as in Hellquist, et al². The models did not specify any mode of inheritance. P values were obtained with the likelihood ratio test.
↵** Comparison of the specific inheritance models included in LRASSOC⁹. Akaike’s Information Criterion (AIC) was used to classify the models. A value of AIC > 2 indicates a meaningful difference.
↵† Additive: model with additive effects of each SNP, without dominance or interactive components. SNP: single-nucleotide polymorphisms.