Article Figures & Data
Figures
- Figure 1
Scatterplot and linear regression between waist circumference at the first visit (WC1) and uric acid at the first visit (UA1) and those between body mass index at the first visit (BMI1) and UA1 in premenopausal and postmenopausal women and in men. Serum uric acid values were not adjusted for age or other possible confounders.
- Figure 2
Scatterplot and linear regression between percentage change in waist circumference (%dWC) and percentage change in uric acid (%dUA), and those between percentage change in BMI (%dBMI) and %dUA in premenopausal and postmenopausal women and in men. Serum uric acid values were not adjusted for age or other possible confounders.
Tables
%dUA Quartile Variables Total, n First (range -47.2/–7.5) Second (range –7.4/–1.2) Third (range 0.0/7.1) Fourth (range 7.2/77.8) p for Trend Women/men 1185/1968 290/496 252/483 327/514 316/475 Baseline data at visit 1 Age, yrs 52.8 ± 10.2 52.6 ± 10.6 53.3 ± 10.1 52.9 ± 10.0 52.3 ± 10.2 0.225 Waist circumference, cm 82.3 ± 9.2 82.8 ± 9.6 82.7 ± 9.1 82.2 ± 8.7 81.7 ±9.3 0.074 Body mass index, kg/m2 22.8 ± 3.1 23.0 ± 3.3 22.8 ± 3.0 22.8 ± 3.0 22.6 ± 3.1 0.056 Systolic blood pressure, mmHg 123 ± 19 124 ± 20 123 ± 19 122 ± 19 123 ± 19 0.636 LDL-cholesterol, mg/dl 129.1 ± 31.2 130.2 ± 31.3 129.4 ± 29.5 129.8 ± 31.3 126.9 ± 32.2 0.147 HDL-cholesterol, mg/dl 60.7 ± 15.3 60.7 ± 15.8 60.5 ± 15.5 60.8 ± 14.8 60.9 ± 15.1 0.980 Triglyceride, mg/dl 111 ± 72 112 ± 75 115 ± 81 109 ± 67 109 ± 65 0.249 Uric acid, mg/dl 5.5 ± 1.3 5.8 ± 1.5 5.7 ± 1.2 5.4 ± 1.3 5.1 ± 1.2 < 0.001 Fasting glucose, mg/dl 96 ± 21 97 ± 20 96 ± 19 95 ± 18 96 ± 25 0.486 Hemoglobin A1c, % 5.3 ± 0.7 5.3 ± 0.7 5.3 ± 0.7 5.3 ± 0.7 5.3 ± 0.9 0.941 Blood urea nitrogen, mg/dl 14.1 ± 3.5 14.6 ± 4.0 14.3 ± 3.2 14.1 ± 3.3 13.6 ± 3.5 < 0.001 Serum creatinine, mg/dl 0.77 ± 0.29 0.79 ± 0.42 0.78 ± 0.15 0.76 ± 0.15 0.75 ± 0.34 0.068 Estimated glomerular filtration rate, ml/min/1.73m2 68.3 ± 11.8 67.3 ± 11.8 67.8 ± 11.5 68.1 ± 11.4 70.2 ± 12.4 < 0.001 Antihypertensive medication, n (%) 306 (9.7) 78 (9.9) 78 (10.6) 76 (9.0) 74 (9.4) 0.736 Antidiabetic medication, n (%) 74 (2.3) 19 (2.4) 14 (1.9) 24 (2.9) 17 (2.1) 0.632 Postmenopause (female), n (%) 649 (54.8) 152 (52.4) 141 (56.0) 194 (59.3) 162 (51.3) 0.165 Current smoker, n (%) 734 (23.3) 180 (22.9) 173 (23.5) 197 (23.4) 184 (23.3) 0.992 Percent change between 2 visits %dBMI –0.28 ± 3.1 –0.70 ± 3.41 –0.46 ± 3.06 0.01 ± 2.88 –0.03 ± 2.98 < 0.001 %dWC 0.17 ± 6.12 –0.02 ± 6.33 –0.35 ± 6.14 0.64 ± 6.14 0.35 ± 5.83 0.008 %deGFR 1.8 ± 10.0 6.3 ± 10.0 2.6 ± 9.0 0.9 ± 9.1 –2.5 ± 10.0 < 0.001 ß (95% CI) Standardized ß p Premenopausal women Model 1 UA1 –4.21 (–5.42, –3.00) –0.28 < 0.001 Model 2 UA1 –4.21 (–5.42, –3.00) –0.28 < 0.001 Model 3 UA1 –4.21 (–5.42, –3.00) –0.28 < 0.001 Model 4 %deGFR –0.43 (–0.53, –0.33) –0.34 < 0.001 UA1 –3.70 (–4.84, –2.56) –0.25 < 0.001 Model 5 %deGFR –0.43 (–0.53, –0.33) –0.34 < 0.001 UA1 –3.70 (–4.84, –2.56) –0.25 < 0.001 Postmenopausal women Model 1 UA1 –3.09 (–4.05, –2.13) –0.24 < 0.001 Model 2 UA1 –3.04 (–4.00, –2.09) –0.24 < 0.001 %dBMI 0.53 (0.26, 0.81) 0.14 < 0.001 Model 3 UA1 –3.04 (–4.00, –2.09) –0.24 < 0.001 %dBMI 0.53 (0.26, 0.81) 0.14 < 0.001 Model 4 %deGFR –0.33 (–0.41, –0.25) –0.30 < 0.001 UA1 –2.83 (–3.73, –1.92) –0.22 < 0.001 %dBMI 0.55 (0.29, 0.81) 0.15 < 0.001 Model 5 %deGFR –0.33 (–0.41, –0.25) –0.30 < 0.001 UA1 –2.83 (–3.73, –1.92) –0.22 < 0.001 %dBMI 0.55 (0.29, 0.81) 0.15 < 0.001 Men Model 1 UA1 –2.51 (–2.90, –2.12) –0.27 < 0.001 %dWC 0.14 (0.04, 0.25) 0.06 0.008 Model 2 UA1 –2.49 (–2.88, –2.10) –0.27 < 0.001 %dBMI 0.32 (0.17, 0.48) 0.09 < 0.001 Model 3 UA1 –2.51 (–2.89, –2.12) –0.27 < 0.001 %dBMI 0.38 (0.22, 0.54) 0.10 < 0.001 %dBPs –0.06 (–0.10, –0.02) –0.06 0.006 Model 4 %deGFR –0.36 (–0.40, –0.31) –0.32 < 0.001 UA1 –2.29 (–2.66, –1.92) –0.25 < 0.001 %dBMI 0.35 (0.21, 0.50) 0.10 < 0.001 Model 5 %deGFR –0.36 (–0.40, –0.31) –0.32 < 0.001 UA1 –2.29 (–2.66, –1.92) –0.25 < 0.001 %dBMI 0.35 (0.21, 0.50) 0.10 < 0.001 -
Model 1. Independent variables include age, UA1, WC1, and %dWC. Model 2. Independent variables include Model 1 + BMI1 and %dBMI. Model 3. Independent variables include Model 2 + %dBPs. Model 4. Independent variables include Model 2 + %deGFR. Model 5. Independent variables include Model 2 + %dBPs and %deGFR. UA: uric acid; BMI: body mass index; BPs: systolic blood pressure; eGFR: estimated glomerular filtration rate.
-
- Table 3
Logistic regression analysis using the highest or lowest %dUA quartile as the dependent variable.
Independent Variable %dUA ≥ 7.2% %dUA < –7.5% OR (95% CI) p OR (95% CI) p Premenopausal women Model 1 %dBMI quartile First 1.19 (0.73, 1.94) 0.474 2 and 3 1 Reference 4 0.65 (0.42, 0.99) 0.046 1.00 Reference Model 2 %dBMI quartile First 1.41 (0.85, 2.34) 0.181 2 and 3 1.00 Reference 4 0.71 (0.45, 1.10) 0.126 1.00 Reference %deGFR 0.93 (0.91, 0.95) < 0.001 1.06 (1.04, 1.08) < 0.001 %dBPs 0.99 (0.97, 1.01) 0.225 1.00 (0.98, 1.02) 0.804 Postmenopausal women Model 1 %dBMI quartile First 2.04 (1.37, 3.03) < 0.001 2 and 3 1.00 Reference 4 1.60 (1.06, 2.41) 0.025 1.00 Reference Model 2 %dBMI First 2.04 (1.35, 3.07) 0.001 2 and 3 1.00 Reference 4 1.72 (1.12, 2.63) 0.013 1.00 Reference %deGFR 0.95 (0.93, 0.97) < 0.001 1.05 (1.03, 1.07) < 0.001 %dBPs 0.98 (0.97, 1.00) 0.039 1.00 (0.98, 1.01) 0.684 Men Model 1 %dBMI quartile First 1.35 (1.07, 1.69) 0.011 2 and 3 1.00 Reference 4 1.38 (1.08, 1.76) 0.010 1.00 Reference Model 2 %dBMI quartile First 1.46 (1.14, 1.86) 0.002 2 and 3 1.00 Reference 4 1.49 (1.15, 1.92) 0.002 1.00 Reference %deGFR 0.94 (0.92, 0.95) < 0.001 1.07 (1.06, 1.08) < 0.001 %dBPs 1.00 (0.99, 1.01) 0.300 1.00 (0.99, 1.01) 0.715 -
Model 1. Independent variables include age, UA1, BMI1, and %dBMI quartiles. Model 2. Independent variables include Model 1 + %dBPs and %deGFR. UA: uric acid; BMI: body mass index; BPs: systolic blood pressure; eGFR: estimated glomerular filtration rate.
-
In this issue
