Article Figures & Data
Figures
- Figure 1
Sex-stratified EQ-5D scores (A: women; B: men) for the general population and patients with RA grouped according to disease activity using the DAS28 and CDAI criteria.
Tables
- Table 1
Patient characteristics for all respondents and stratified according to disease activity using the DAS28 and CDAI criteria (n = 3156). Values are median (interquartile range) unless otherwise stated.
All Patients, Remission Low Disease Activity Moderate Disease Activity High Disease Activity
n = 3156DAS28, n = 1175 CDAI, n = 683 DAS28, n = 588 CDAI, n = 1351 DAS28, n = 1142 CDAI, n = 785 DAS28, n = 251 CDAI, n = 337 Women, % 75 71 67 75 74 78 80 78 79 Age, yrs 62 (52–70) 61 (52–68) 61 (51–68) 63 (53–71) 63 (53–70) 61 (52–70) 61 (51–69) 60 (50–69) 59 (51–70) Disease duration, yrs 7 (3–15) 7 (3–14) 6 (3–12) 8 (3–16) 8 (3–16) 8 (3–16) 7 (2–15) 6 (1–15) 5 (1–15) HAQ score (0–3) 0.63 (0.25–1.25) 0.25 (0–0.63) 0.13 (0–0.50) 0.63 (0.25–1.13) 0.63 (0.25–1.13) 0.88 (0.50–1.38) 0.88 (0.50–1.50) 1.50 (1.00–2.00) 1.40 (0.75–1.88) Radiographic erosions, % 65 63 58 71 69 63 63 62 59 IgM-rheumatoid factor positive, % 77 76 73 81 79 76 76 74 73 Biological therapy, % 20 18 21 21 19 20 20 22 22 Use of methotrexate, % 72 75 76 74 74 70 70 62 63 Glucocorticoid use past month, % 21 15 11 20 20 24 24 38 36 -
DAS28: Disease Activity Score; CDAI: Clinical Disease Activity Index.
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- Table 2A
EQ-5D scores for the female general population (n = 8543) and RA patients (n = 2183) stratified according to age and disease activity using the DAS28 and CDAI criteria. Data are mean (standard deviation).
Age, yrs Norm Remission Low Disease Activity Moderate Disease Activity High Disease Activity n n DAS28 n CDAI n DAS28 n CDAI n DAS28 n CDAI n DAS28 n CDAI <45 4008 0.90 (0.14) 127 0.84 (0.11) 86 0.86 (0.10) 58 0.75 (0.10) 126 0.77 (0.10) 135 0.68 (0.13) 94 0.67 (0.14) 32 0.46 (0.27) 46 0.51 (0.25) 45–64 3062 0.86 (0.17) 389 0.80 (0.11) 212 0.83 (0.11) 200 0.74 (0.12) 452 0.74 (0.12) 389 0.65 (0.15) 286 0.63 (0.15) 83 0.47 (0.20) 111 0.52 (0.20) 65–93 1473 0.80 (0.21) 258 0.78 (0.16) 140 0.84 (0.13) 160 0.69 (0.15) 346 0.71 (0.15) 290 0.67 (0.16) 198 0.65 (0.17) 62 0.49 (0.24) 86 0.53 (0.23) Total 8543 0.87 (0.17) 774 0.80 (0.13) 438 0.84 (0.11) 418 0.72 (0.13) 924 0.73 (0.13) 814 0.66 (0.15) 578 0.65 (0.16) 177 0.47 (0.23) 243 0.52 (0.22) - Table 2B
EQ-5D scores for the male general population (n = 7593) and RA patients (n = 729) stratified according to disease activity using the DAS28 and CDAI criteria. Data are mean (standard deviation).
Age, yrs Norm Remission Low Disease Activity Moderate Disease Activity High Disease Activity n n DAS28 n CDAI n DAS28 n CDAI n DAS28 n CDAI n DAS28 n CDAI <45 3370 0.93 (0.12) 27 0.86 (0.10) 17 0.87 (0.11) 8 0.77 (0.06) 25 0.80 (0.08) 23 0.69 (0.17) 14 0.64 (0.20) 4 0.51 (0.17) 6 0.60 (0.20) 45–64 2914 0.89 (0.15) 156 0.82 (0.12) 104 0.86 (0.11) 48 0.72 (0.12) 128 0.73 (0.11) 100 0.66 (0.17) 65 0.63 (0.18) 26 0.62 (0.14) 33 0.62 (0.14) 65–89 1309 0.85 (0.18) 145 0.81 (0.13) 97 0.85 (0.11) 61 0.75 (0.15) 150 0.73 (0.14) 106 0.68 (0.16) 62 0.66 (0.17) 25 0.59 (0.20) 28 0.62 (0.22) Total 7593 0.90 (0.15) 328 0.82 (0.12) 218 0.86 (0.11) 117 0.74 (0.13) 303 0.74 (0.13) 229 0.68 (0.16) 141 0.64 (0.18) 55 0.60 (0.17) 67 0.62 (0.18) - Table 3
EQ-5D score differences (∆EQ-5D) between the general population and RA patients [(norm)–(patients)] (n = 2912). Values are mean (standard deviation). EQ-5D norm values used in the calculation of the ∆EQ-5D may differ from the norm values observed in Table 2A and 2B because of the different age distribution in the norm and patient sample. This may lead to slightly different ΔEQ-5D values than could be expected from Table 2A and 2B.
Women Men n DAS28 n CDAI n DAS28 n CDAI Remission 774 0.05 (0.13)* 438 0.01 (0.12) NS 328 0.06 (0.12)* 218 0.02 (0.11)* Low 418 0.12 (0.13)* 924 0.11 (0.13)* 117 0.13 (0.13)* 303 0.14 (0.11)* Moderate 814 0.18 (0.15)* 578 0.20 (0.16)* 229 0.20 (0.17)* 141 0.23 (0.18)* High 177 0.38 (0.23)* 243 0.33 (0.22)* 55 0.28 (0.17)* 67 0.26 (0.18)* -
↵* Significant differences (one sample t test) between the general population and RA patients.
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- Table 4
Regression model estimates illustrating the association of disease activity with EQ-5D score differences (∆EQ-5D) between the general population and patients with RA (n = 2912). Estimates were adjusted for age, marital status, education level, body mass index, exercise, smoking status, disease duration, extraarticular features, joint surgery, IgM-rheumatoid factor status, comorbidities, and treatment with methotrexate, biological antirheumatic drugs and glucocorticoid.
Women, n = 2183 Men, n = 729 DAS28 CDAI DAS28 CDAI Remission Reference Reference Reference Reference Low 0.07 (0.05–0.09) 0.09 (0.07–0.11) 0.07 (0.04–0.10) 0.11 (0.09–0.13) Moderate 0.12 (0.11–0.13) 0.17 (0.15–0.18) 0.13 (0.11–0.16) 0.20 (0.17–0.22) High 0.29 (0.27–0.32) 0.28 (0.26–0.30) 0.20 (0.16–0.24) 0.22 (0.18–0.25) R2 0.35 0.35 0.28 0.33 -
All estimates were statistically significant at the 0.001 level.
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