Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Review ArticleArticle

Intraarticular Botulinum Toxin A for Refractory Painful Total Knee Arthroplasty: A Randomized Controlled Trial

JASVINDER A. SINGH, MAREN L. MAHOWALD and SIAMAK NOORBALOOCHI
The Journal of Rheumatology November 2010, 37 (11) 2377-2386; DOI: https://doi.org/10.3899/jrheum.100336
JASVINDER A. SINGH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Jasvinder.md@gmail.com
MAREN L. MAHOWALD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SIAMAK NOORBALOOCHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

REFERENCES

  1. 1.↵
    1. Ethgen O,
    2. Bruyere O,
    3. Richy F,
    4. Dardennes C,
    5. Reginster JY
    . Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature. J Bone Joint Surg Am 2004;86:963–74.
    OpenUrlPubMed
  2. 2.↵
    1. Kurtz S,
    2. Ong K,
    3. Lau E,
    4. Mowat F,
    5. Halpern M
    . Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007;89:780–5.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Brander VA,
    2. Stulberg SD,
    3. Adams AD,
    4. Harden RN,
    5. Bruehl S,
    6. Stanos SP,
    7. et al.
    Predicting total knee replacement pain: a prospective, observational study. Clin Orthop Relat Res 2003;416:27–36.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Singh JA,
    2. Gabriel S,
    3. Lewallen D
    . The impact of gender, age, and preoperative pain severity on pain after TKA. Clin Orthop Relat Res 2008;466:2717–23.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Brown EC 3rd.,
    2. Clarke HD,
    3. Scuderi GR
    . The painful total knee arthroplasty: diagnosis and management. Orthopedics 2006;29:129–36; quiz 37–8.
    OpenUrlPubMed
  6. 6.↵
    1. Ahmed M,
    2. Bergstrom J,
    3. Lundblad H,
    4. Gillespie WJ,
    5. Kreicbergs A
    . Sensory nerves in the interface membrane of aseptic loose hip prostheses. J Bone Joint Surg Br 1998;80:151–5.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Pritchett JW
    . Substance P level in synovial fluid may predict pain relief after knee replacement. J Bone Joint Surg Br 1997;79:114–6.
    OpenUrlPubMed
  8. 8.↵
    1. Jabbari B
    . Botulinum neurotoxins in the treatment of refractory pain. Nat Clin Pract Neurol 2008;4:676–85.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Jankovic J,
    2. Schwartz K
    . Botulinum toxin injections for cervical dystonia. Neurology 1990;40:277–80.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Gobel H,
    2. Heinze A,
    3. Heinze-Kuhn K,
    4. Jost W
    . Evidence based medicine: Botulinum toxin A in migraine and tension type headache. J Neurol 2001;248 Suppl:34–8.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Keizer S,
    2. Rutten H,
    3. Pilot P,
    4. Morre H,
    5. Os J,
    6. Verburg A
    . Botulinum toxin injection versus surgical treatment for tennis elbow: a randomized pilot study. Clin Orthop 2002;401:125–31.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Porta M
    . A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm. Pain 2000;85:101–5.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Wheeler AH,
    2. Goolkasian P,
    3. Gretz SS
    . A randomized, double-blind, prospective pilot study of botulinum toxin injection for refractory, unilateral, cervicothoracic, paraspinal, myofascial pain syndrome. Spine 1998;23:1662–6; discussion 7.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Marco E,
    2. Duarte E,
    3. Vila J,
    4. Tejero M,
    5. Guillen A,
    6. Boza R,
    7. et al.
    Is botulinum toxin type A effective in the treatment of spastic shoulder pain in patients after stroke? A double-blind randomized clinical trial. J Rehabil Med 2007;39:440–7.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Ranoux D,
    2. Attal N,
    3. Morain F,
    4. Bouhassira D
    . Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain. Ann Neurol 2008;64:274–83.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Yuan RY,
    2. Sheu JJ,
    3. Yu JM,
    4. Chen WT,
    5. Tseng IJ,
    6. Chang HH,
    7. et al.
    Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology 2009;72:1473–8.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Kuo HC,
    2. Chancellor MB
    . Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome. BJU Int 2009;104:657–61.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Patti R,
    2. Arcara M,
    3. Bonventre S,
    4. Sammartano S,
    5. Sparacello M,
    6. Vitello G,
    7. et al.
    Randomized clinical trial of botulinum toxin injection for pain relief in patients with thrombosed external haemorrhoids. Br J Surg 2008;95:1339–43.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Mahowald ML,
    2. Singh JA,
    3. Dykstra D
    . Long term effects of intra-articular botulinum toxin A for refractory joint pain. Neurotox Res 2006;9:179–88.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Singh JA,
    2. Mahowald ML
    . Intra-articular botulinum toxin A as an adjunctive therapy for refractory joint pain in patients with rheumatoid arthritis receiving biologics: a report of two cases. Joint Bone Spine 2009;76:190–4.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Singh JA,
    2. Mahowald ML,
    3. Kushnaryov A,
    4. Goelz E,
    5. Dykstra D
    . Repeat injections of intra-articular botulinum toxin A for the treatment of chronic arthritis joint pain. J Clin Rheumatol 2009;15:35–8.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Singh JA,
    2. Mahowald ML,
    3. Noorbaloochi S
    . Intra-articular botulinum toxin A for refractory shoulder pain: a randomized, double-blinded, placebo-controlled trial. Transl Res 2009;153:205–16.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Boon AJ,
    2. Smith J,
    3. Dahm DL,
    4. Sorenson EJ,
    5. Larson DR,
    6. Fitz-Gibbon PD,
    7. et al.
    Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. Phys Med Rehabil 2010;2:268–76.
    OpenUrl
  24. 24.↵
    1. Singh JA,
    2. Fitzgerald P
    . Botulinum toxin for shoulder pain [in press]. Cochrane Database Syst Rev 2010.
  25. 25.↵
    1. Birklein F,
    2. Schmelz M
    . Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS). Neurosci Lett 2008;437:199–202.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Meng J,
    2. Wang J,
    3. Lawrence G,
    4. Dolly JO
    . Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential. J Cell Sci 2007;120:2864–74.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Purkiss J,
    2. Welch M,
    3. Doward S,
    4. Foster K
    . Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms. Biochem Pharmacol 2000;59:1403–6.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Lucioni A,
    2. Bales GT,
    3. Lotan TL,
    4. McGehee DS,
    5. Cook SP,
    6. Rapp DE
    . Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation. BJU Int 2008;101:366–70.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Rapp DE,
    2. Turk KW,
    3. Bales GT,
    4. Cook SP
    . Botulinum toxin type a inhibits calcitonin gene-related peptide release from isolated rat bladder. J Urol 2006;175:1138–42.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Cui M,
    2. Khanijou S,
    3. Rubino J,
    4. Aoki KR
    . Subcutaneous administration of botulinum toxin A reduces formalin-induced pain. Pain 2004;107:125–33.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Singh J,
    2. Mahowald M,
    3. Krug H,
    4. Gioe T,
    5. Santos E,
    6. Schmidt R
    . Intra-articular botulinum toxin A for painful total knee arthroplasty (TKA) [abstract]. Arthritis Rheum 2006;54 Suppl:S541–2.
    OpenUrl
  32. 32.↵
    1. Courtney P,
    2. Doherty M
    . Joint aspiration and injection. Best Pract Res Clin Rheumatol 2005;19:345–69.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Lopes RV,
    2. Furtado RN,
    3. Parmigiani L,
    4. Rosenfeld A,
    5. Fernandes AR,
    6. Natour J
    . Accuracy of intra-articular injections in peripheral joints performed blindly in patients with rheumatoid arthritis. Rheumatology 2008;47:1792–4.
    OpenUrlAbstract/FREE Full Text
  34. 34.↵
    1. Farrar JT,
    2. Portenoy RK,
    3. Berlin JA,
    4. Kinman JL,
    5. Strom BL
    . Defining the clinically important difference in pain outcome measures. Pain 2000;88:287–94.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Gallagher EJ,
    2. Liebman M,
    3. Bijur PE
    . Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med 2001;38:633–8.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Turk DC,
    2. Rudy TE,
    3. Sorkin BA
    . Neglected topics in chronic pain treatment outcome studies: determination of success. Pain 1993;53:3–16.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Bijur PE,
    2. Silver W,
    3. Gallagher EJ
    . Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med 2001;8:1153–7.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Farrar JT,
    2. Young JP Jr.,
    3. LaMoreaux L,
    4. Werth JL,
    5. Poole RM
    . Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001;94:149–58.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Tubach F,
    2. Ravaud P,
    3. Baron G,
    4. Falissard B,
    5. Logeart I,
    6. Bellamy N,
    7. et al.
    Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement. Ann Rheum Dis 2005;64:29–33.
    OpenUrlAbstract/FREE Full Text
  40. 40.↵
    1. Bellamy N,
    2. Campbell J,
    3. Hill J,
    4. Band P
    . A comparative study of telephone versus onsite completion of the WOMAC 3.0 osteoarthritis index. J Rheumatol 2002;29:783–6.
    OpenUrlAbstract/FREE Full Text
  41. 41.↵
    1. Bellamy N,
    2. Buchanan WW,
    3. Goldsmith CH,
    4. Campbell J,
    5. Stitt LW
    . Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833–40.
    OpenUrlPubMed
  42. 42.↵
    1. Newcomber K,
    2. Krug H,
    3. Mahowald M
    . Validity and reliability of the timed stands test for patients with rheumatoid arthritis and other chronic diseases. J Rheumatol 1993;20:21–7.
    OpenUrlPubMed
  43. 43.↵
    1. Podsiadlo D,
    2. Richardson S
    . The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991;39:142–8.
    OpenUrlPubMed
  44. 44.↵
    1. Gagey OJ,
    2. Gagey N
    . The hyperabduction test. J Bone Joint Surg Br 2001;83:69–74.
    OpenUrlCrossRefPubMed
  45. 45.↵
    1. Katz JN,
    2. Larson MG,
    3. Phillips CB,
    4. Fossel AH,
    5. Liang MH
    . Comparative measurement sensitivity of short and longer health status instruments. Med Care 1992;30:917–25.
    OpenUrlCrossRefPubMed
  46. 46.↵
    1. Ware JE Jr.,
    2. Sherbourne CD
    . The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473–83.
    OpenUrlCrossRefPubMed
  47. 47.↵
    1. Melzack R
    . The short-form McGill Pain Questionnaire. Pain 1987;30:191–7.
    OpenUrlCrossRefPubMed
  48. 48.↵
    1. Frette C,
    2. Barrett-Connor E,
    3. Clausen JL
    . Effect of active and passive smoking on ventilatory function in elderly men and women. Am J Epidemiol 1996;143:757–65.
    OpenUrlAbstract/FREE Full Text
  49. 49.↵
    1. Watanabe KI,
    2. Minabe Y,
    3. Ashby CR Jr.,
    4. Katsumori H
    . Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats. Eur J Pharmacol 1998;350:181–8.
    OpenUrlCrossRefPubMed
  50. 50.↵
    1. Bellamy N,
    2. Bell MJ,
    3. Goldsmith CH,
    4. Pericak D,
    5. Walker V,
    6. Raynauld JP,
    7. et al.
    The effectiveness of hylan G-F 20 in patients with knee osteoarthritis: an application of two sets of response criteria developed by the OARSI and one set developed by OMERACT-OARSI. Osteoarthritis Cartilage 2005;13:104–10.
    OpenUrlCrossRefPubMed
  51. 51.↵
    1. Sangha O,
    2. Stucki G,
    3. Liang MH,
    4. Fossel AH,
    5. Katz JN
    . The Self-Administered Comorbidity Questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis Rheum 2003;49:156–63.
    OpenUrlCrossRefPubMed
  52. 52.↵
    1. Wright JG,
    2. Young NL
    . A comparison of different indices of responsiveness. J Clin Epidemiol 1997;50:239–46.
    OpenUrlCrossRefPubMed
  53. 53.↵
    1. Gentelle-Bonnassies S,
    2. Le Claire P,
    3. Mezieres M,
    4. Ayral X,
    5. Dougados M
    . Comparison of the responsiveness of symptomatic outcome measures in knee osteoarthritis. Arthritis Care Res 2000;13:280–5.
    OpenUrlCrossRefPubMed
  54. 54.↵
    1. van der Windt DA,
    2. Koes BW,
    3. Deville W,
    4. Boeke AJ,
    5. de Jong BA,
    6. Bouter LM
    . Effectiveness of corticosteroid injections versus physiotherapy for treatment of painful stiff shoulder in primary care: randomised trial. BMJ 1998;317:1292–6.
    OpenUrlAbstract/FREE Full Text
  55. 55.↵
    1. Carette S,
    2. Moffet H,
    3. Tardif J,
    4. Bessette L,
    5. Morin F,
    6. Fremont P,
    7. et al.
    Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: a placebo-controlled trial. Arthritis Rheum 2003;48:829–38.
    OpenUrlCrossRefPubMed
  56. 56.↵
    1. Lo GH,
    2. LaValley M,
    3. McAlindon T,
    4. Felson DT
    . Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 2003;290:3115–21.
    OpenUrlCrossRefPubMed
  57. 57.↵
    1. Espallargues M,
    2. Pons JM
    . Efficacy and safety of viscosupplementation with Hylan G-F 20 for the treatment of knee osteoarthritis: a systematic review. Int J Technol Assess Health Care 2003;19:41–56.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 37, Issue 11
1 Nov 2010
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Intraarticular Botulinum Toxin A for Refractory Painful Total Knee Arthroplasty: A Randomized Controlled Trial
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Intraarticular Botulinum Toxin A for Refractory Painful Total Knee Arthroplasty: A Randomized Controlled Trial
JASVINDER A. SINGH, MAREN L. MAHOWALD, SIAMAK NOORBALOOCHI
The Journal of Rheumatology Nov 2010, 37 (11) 2377-2386; DOI: 10.3899/jrheum.100336

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Intraarticular Botulinum Toxin A for Refractory Painful Total Knee Arthroplasty: A Randomized Controlled Trial
JASVINDER A. SINGH, MAREN L. MAHOWALD, SIAMAK NOORBALOOCHI
The Journal of Rheumatology Nov 2010, 37 (11) 2377-2386; DOI: 10.3899/jrheum.100336
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Acknowledgment
    • Footnotes
    • REFERENCES
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • National Sjögren’s Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life
  • Comparing the Visual Analog Scale and the Numerical Rating Scale in Patient-reported Outcomes in Psoriatic Arthritis
  • STRATUS: A Phase II Study of Abituzumab in Patients With Systemic Sclerosis–associated Interstitial Lung Disease
Show more Articles

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire