Article Figures & Data
Tables
- Table 1.
Overview of the main findings of the cluster analysis based on similarity of the patients’ clinical profiles. The frequency distribution of the various characteristics of the clusters are shown. Pulmonary involvement was defined as the presence of bibasilar fibrosis on standard chest radiographs or high-resolution computed tomography scans and/or pulmonary arterial hypertension detected by means of color Doppler echocardiography and confirmed by right-heart catheterization; esophageal involvement as barium radiography hypomotility; cardiac involvement as the presence of pericarditis, arrhythmia, or left ventricular congestive heart failure; renal involvement as malignant hypertension and/or rapidly progressive renal failure; hand involvement was defined as the presence of arthralgia, arthritis, flexion contractures, and/or digital ulcers. Data are percentages.
Feature Group A: Minor Extent of Organ Involvement, N = 61 Cluster B: Major Extent of Organ Involvement, N = 19 Complete Case Series, N = 80 dcSSc 8 79 25 lcSSc 92 21 75 Hand involvement Arthralgias 44 63 49 Arthritis 10 11 10 Digital ulcers 41 63 46 Flexion contractures 13 74 28 Heart involvement 10 79 26 Lung involvement Bibasilar fibrosis 34 95 49 Pulmonary arterial hypertension 10 63 23 Esophagus involvement 62 89 69 -
dcSSc: diffuse cutaneous systemic sclerosis; lcSSc: limited cutaneous systemic sclerosis.
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- Table 2.
Discriminating capacity of the hand function indices in relation to the 2 patient groups with minor and major extent of organ involvement.
Model C-Index (95% CI) Best Cutoff for Classifying Major Extent of Organ Involvement Sensitivity Specificity HAI 0.80 (0.66–0.91) ≤ 2.6 79 79 HAMIS 0.81 (0.69–0.91) ≥ 4.5 63 89 FTP 0.73 (0.60–0.87) ≥ 1.5 58 82 HAI + FTP 0.84 (0.73–0.93) HAI ≤ 2.5, FTP ≥ 1 74 80 FTP + HAMIS 0.82 (0.71–0.92) HAMIS ≥ 2.5, FTP ≥ 1 79 71 HAI + HAMIS 0.83 (0.72–0.94) HAI ≤ 2.5, HAMIS ≥ 2.5 79 85 HAI + HAMIS + FTP 0.85 (0.74–0.95) HAMIS ≥ 4.5, HAI ≤ 2.6, FTP ≥ 0.5 84 79 -
HAI: Hand Anatomic Index; HAMIS: Hand Mobility in Scleroderma; FTP: finger-to-palm distance.
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