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Research ArticleArticle

Premature Aortic Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Transesophageal Echocardiographic Study

CARLOS A. ROLDAN, JOSEPH JOSON, JANEEN SHARRAR, CLIFFORD R. QUALLS and WILMER L. SIBBITT Jr
The Journal of Rheumatology January 2010, 37 (1) 71-78; DOI: https://doi.org/10.3899/jrheum.090665
CARLOS A. ROLDAN
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  • For correspondence: croldan@salud.unm.edu
JOSEPH JOSON
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JANEEN SHARRAR
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CLIFFORD R. QUALLS
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WILMER L. SIBBITT Jr
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Abstract

Objective. Premature carotid and coronary atherosclerosis are common in systemic lupus erythematosus (SLE), but data on aortic atherosclerosis (AA) are limited. Thus, using multiplane transesophageal echocardiography (TEE), we sought to determine the prevalence and clinical correlates of AA in patients with SLE.

Methods. Forty-seven patients with SLE (44 women, age 38 ± 12 years) and 21 healthy controls (19 women, age 34 ± 12 years) underwent clinical and laboratory evaluations and TEE to assess AA defined as aortic intima media thickness (IMT) > 0.86 mm or plaques as > 50% focal IMT as compared with surrounding walls. TEE studies were interpreted by an experienced observer unaware of subjects’ clinical data.

Results. The prevalence of abnormal aortic IMT, plaques, or both lesions was higher in patients as compared to controls (37%, 23%, and 43% vs 14%, 0%, and 14%, respectively, all p ≤ 0.02). In patients, age at diagnosis of SLE was the only positive independent predictor of AA [OR 1.12 per year from diagnosis of SLE, 95% confidence interval (CI) 1.04–1.19, p = 0.001] and cyclophosphamide therapy was the only negative independent predictor of AA (OR 0.186, 95% CI 0.153–0.95, p = 0.04, equivalent to 5.4 times less likely to develop AA).

Conclusion. AA is common in young patients with SLE and is predicted by a later age at diagnosis of SLE, but is negatively correlated with cyclophosphamide therapy. Thus, early diagnosis and more aggressive immunosuppressive therapy may be required to decrease the development and progression of atherosclerosis in patients with SLE.

  • AORTA
  • ATHEROSCLEROSIS
  • TRANSESOPHAGEAL ECHOCARDIOGRAPHY
  • SYSTEMIC LUPUS ERYTHEMATOSUS

Cardiovascular and cerebrovascular diseases are common in patients with systemic lupus erythematosus (SLE), a situation that substantially increases their morbidity and mortality1–4. Patients with SLE have a higher prevalence of carotid plaques and coronary artery calcifications than matched controls (37% and 31% vs 7–15% and 9%, respectively) after controlling for traditional atherogenic risk factors5–7. The SLE-associated immune mediated systemic inflammation is believed to be the primary pathogenic or exacerbating factor for development of atherosclerosis8–10. Aortic atherosclerosis (AA) in non-SLE populations is associated with carotid, coronary, and peripheral arterial atherosclerosis, which predicts a 2 to 5-fold increase in future cerebral, cardiac, and peripheral arterial ischemic events and mortality11–15. In patients with SLE, AA may have similar clinical and prognostic implications. However, unlike carotid or coronary atherosclerosis, the prevalence of AA in patients with SLE is unknown. Therefore, this study was designed to determine the prevalence and clinical correlates of AA using multiplane transesophageal echocardiography (TEE) in patients with SLE as compared to age- and gender-matched healthy controls.

MATERIALS AND METHODS

Study populations

This study protocol was approved by the Institutional Review Board of the University of New Mexico and conformed to the Declaration of Helsinki. All subjects participated only after signing a written informed consent. Forty-seven consecutive patients with a diagnosis of SLE according to the American Rheumatism Association criteria, 44 of them women, with a mean age of 38 ± 12 years (range, 18–60), and 21 healthy volunteers, 19 of them women, with a mean age of 34 ± 12 years (range, 18–57), agreed to participate in the study. Patients with SLE were recruited from a well-characterized population of ~200 patients between 18 and 60 years old regularly followed at the Rheumatology Clinics of the University of New Mexico Health Sciences Center. Subjects > 60 years old with or without SLE were excluded because of the higher prevalence of atherosclerosis in this age group16,17.

Clinical and laboratory evaluations

Patients with SLE and controls underwent general clinical and laboratory evaluations including specific measurements of inflammation, coagulation, and fibrinolysis. In addition, patients with SLE were well characterized regarding their demographics; traditional atherogenic risk factors; disease duration, activity, severity, and therapy; standard serology; and antiphospholipid antibody status.

Transesophageal echocardiography

All subjects underwent multiplane TEE with Philips I-E33 systems (Andover, MA) using a 7 MHZ phased array transducer with an axial resolution of 0.1 mm. At a low depth (3–4 cm) and using a narrow sector scan to improve image lateral resolution, 2-dimensional guided M-mode images were used to assess intima media thickness (IMT) and plaques of the anterior wall of the aortic arch and proximal (at 25–30 cm from the incisors), mid (at 30–35 cm), and distal descending thoracic aorta (at 35–40 cm). Also, 2-dimensional images were used to assess aortic IMT and plaques of the medial and lateral walls. Near-field limited resolution precluded accurate assessment of the aortic posterior wall. Also, far-field limited resolution precluded an accurate assessment of IMT of the ascending aorta, but not of plaques. Measurements of IMT were performed from the aortic short and long axis views and during end-diastole after the electrocardiographic P wave. All studies were digitally stored and quantitatively measured off-line using electronic calipers. At each aortic level, 3-6 measurements (from short and long axis views) of the anterior IMT were averaged to determine the mean ± 1SD, minimum, and maximum aortic IMT values. All studies were codified and studies of patients and controls were randomly intermixed and interpreted by an experienced observer unaware of subjects’ clinical data.

Criteria for interpretation

In the absence of reported IMT values in healthy subjects, AA was defined as abnormal aortic IMT of > 0.86 mm (value corresponding to the mean in normal controls plus 1.5 SD and which in a receiver-operating curve provided a specificity of 91%) or plaques defined as > 50% focal or protruding wall thickening as compared with surrounding walls5,18,19 (Figure 1).

Figure 1.
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Figure 1.

Aortic Intima-Media Thickening and Plaques by TEE. Short axis (A) and long axis (B) 2-dimensional guided M-mode images of the anterior wall at the mid-level (30 cm) of the descending thoracic aorta demonstrating normal intima media thickness (IMT) of < 8 mm (arrows) in a 50-year-old woman with SLE. C, D. 2-dimensional guided M-mode images of a 48-year-old woman with SLE demonstrating a well-defined aortic plaque of 3.3 mm at the proximal (C, arrow) and abnormal IMT of 1.2 mm at the distal (D, arrow) descending thoracic aorta.

Statistical analysis

Student’s t test or Wilcoxon rank-sum test (for non-normally distributed data) and Fisher’s exact test were used for comparison of continuous and categorical variables among groups, respectively. Univariate and multivariate logistic regression analyses were performed to determine independent effects of clinical and laboratory variables on AA. OR and 95% confidence intervals (CI) were reported. A 2-tailed p value < 0.05 was considered significant.

RESULTS

Characteristics of patients and controls (Table 1)

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Table 1.

Clinical and laboratory data in patients with SLE and controls.

Patients had higher systolic, diastolic, and mean arterial blood pressures, smoked more, had lower hemoglobin, worse renal function and proteinuria, lower albumin, and higher tissue plasminogen activator (tPA) than controls (all p ≤ 0.05). Other measurements of inflammation, coagulation, and fibrinolysis were similar in patients and controls. Specific clinical, therapeutic, and serologic measurements of SLE are delineated in Table 2.

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Table 2.

Clinical and laboratory data in patients with SLE.

Aortic IMT and prevalence of AA in patients and controls

Aortic IMT values at the proximal and mid-levels of the descending aorta and arch were significantly higher in patients than in controls (all p ≤ 0.01, Table 3). The distal descending aorta showed a trend toward significance (p = 0.07). Also, the overall mean and maximum IMT values were higher in patients as compared to controls (both p ≤ 0.002). In both groups, but significantly more in patients with SLE, aortic IMT increased with age (Figure 2). Of most importance, the overall prevalence of abnormal aortic IMT, plaques, or both lesions was higher in patients than in controls (37%, 23%, and 43% vs 14%, 0%, and 14%, respectively, all p ≤ 0.02, Table 3).

Figure 2.
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Figure 2.

Aortic atherosclerosis (AA) vs age by group. By multivariate analyses, age and SLE disease were the only independent predictors of AA [OR 1.08 per year of age increment, 95% confidence interval (CI) 1.025–1.4, p = 0.004 for age effect; and OR 6.7, CI 1.28–35, and p = 0.02, for group (SLE) effect]. The probability of AA in patients with SLE was 40% at age 40 and 80% at age 60 as compared to 10% and 40%, respectively, in controls.

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Table 3.

Aortic intima-media thickness (IMT), abnormal intima-media thickening, and plaques in patients with SLE and controls.

Predictors of aortic atherosclerosis in patients and controls

In multivariate analyses that included all demographic, clinical, and laboratory variables delineated in Table 1, only age and SLE disease were independent predictors of AA (OR 1.08 per year of age increment, 95% CI 1.025 to 1.4, p = 0.004; and OR 6.7 for the SLE group, 95% CI 1.28 to 35, and p = 0.02; Figure 2).

Predictors of AA in patients with SLE (Table 4)

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Table 4.

Predictors of aortic intima-media thickening or plaques in patients with SLE.

In univariate analyses that included all variables delineated in Tables 1 and 2, only age and age at diagnosis of SLE were positive predictors of AA (OR 1.08 per year of age, CI 1.02 to 1.14, p = 0.009, and OR 1.12 per year from age at diagnosis of SLE, CI 1.04 to 1.19, p = 0.001). Cyclophosphamide therapy was a negative predictor of AA (OR 0.172, CI 0.045 to 0.655, p = 0.01, equivalent to 5.8 times less likely to develop AA). In multivariate analyses, only age at diagnosis of SLE and cyclophosphamide therapy were independent predictors of AA (OR = 1.12 per year from age at diagnosis of SLE, 95% CI 1.043 to 1.2, p = 0.001 and OR 0.19, 95% CI 0.15 to 0.95, p = 0.04, equivalent to 5.4 times less likely to develop AA on cyclophosphamide therapy; Figure 3).

Figure 3.
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Figure 3.

Aortic atherosclerosis vs age at diagnosis of SLE by cyclophosphamide therapy. In patients with SLE and by multivariate analyses, age at diagnosis of SLE was the only independent positive predictor and cyclophosphamide (CTX) therapy was the only independent negative predictor of AA (OR = 1.118 per year from diagnosis of SLE, 95% CI 1.037–1.2, p = 0.004 and OR 0.186, CI 0.039–0.875, p = 0.03, equivalent to 5.4 times less likely to develop AA). Probabilities of AA in patients with no cyclophosphamide therapy were nearly 40% at age 20, 80% at age 40, and almost 100% at age 60 as compared to nearly 10% at age 20, 40% at age 40, and 70% at nearly age 60 in patients on cyclophosphamide therapy.

DISCUSSION

There are 3 major findings in this study: (1) aortic IMT values in patients with SLE are higher than in gender- and age-matched controls; (2) the prevalence of AA is also higher in patients with SLE than in matched controls; and (3) age at diagnosis of SLE is the strongest independent positive predictor and cyclophosphamide therapy the independent negative predictor of AA. Therefore, SLE-associated chronic immune-mediated inflammation is an important independent primary or a potentiating pathogenic factor on age and traditional atherogenic risk factors for development or progression of atherosclerosis3,5,7–9,20–22. Other series have demonstrated equivalent prevalence of subclinical carotid and coronary atherosclerosis in SLE3,5,7. In this study, the later the age at diagnosis of SLE, the higher the likelihood of developing AA. In contrast, cyclophosphamide therapy had a protective effect. These findings emphasize the importance of inflammation in the pathogenesis of AA and the need for an early diagnosis and aggressive treatment of SLE5,6,23.

In our study, the lack of an independent association of other specific SLE measurements of inflammation with AA may be explained by 2 factors. First, this SLE cohort was aggressively treated with cyclophosphamide and/or antimetabolites when inflammation was present rather than relying on antimalarials and corticosteroids. Second, inflammation in SLE is variable over time and atherosclerosis likely results from the cumulative effects of inflammation over many years, thus, more aggressive and prolonged noncorticosteroid immunosuppression may have more effective antiatherogenic influence than traditional time-delimited approaches. Also in our study, traditional atherogenic risk factors were not statistically independent predictors of AA. However, these factors likely have an important exacerbating biologic effect on immune-mediated inflammation in the pathogenesis or progression of AA in SLE5,6,24.

In non-SLE populations, a strong association has been demonstrated between moderate to severe degrees of AA (IMT > 4 mm or protruding atheromas) and coronary and cerebrovascular disease 11–15. In these series, AA has shown to be a marker of generalized atherosclerosis and a predictor of a 2–5 fold increased risk of future acute coronary syndromes, stroke or transient ischemic attacks, and cardiac or cerebrovascular mortality. In addition, AA has been proposed to be a substrate for cerebral and peripheral atheroemboli. Thus, AA exacerbated by hypercoagulability in patients with SLE may not only be a marker of coronary and cerebral atherosclerosis, but also a pathogenic factor for cardiac, cerebral, and peripheral arterial thrombotic or thromboembolic ischemic events. In fact, some series in SLE have reported the association of AA with aortic aneurysms or peripheral arterial disease with claudication or ischemic events requiring amputation of digits or extremities25–28.

Comparison with previous studies

No prior study was found in the literature assessing AA in patients with SLE. However, the 43% prevalence of AA found in this study is similar to the reported rates of carotid plaques by ultrasonography (37.1%) and coronary artery calcification (31%) by electron beam computed tomography5,6. Also in these and other series, SLE was an independent predictor of atherosclerosis (OR 6.7, CI 1.28 to 35, p = 0.02), patients with atherosclerosis were diagnosed at a later time, and cyclophosphamide therapy had a protective effect29–31. In addition, as in other series, specific markers of inflammation and antiphospholipid antibodies were not temporally associated with AA. In contrast to previous series, our patient population was younger (mean age 38 ± 12 years) and therefore the observable effects of aging, longterm hyperlipidemia, and of other traditional risk factors for atherosclerosis were reduced.

Pathogenesis of atherosclerosis in SLE

The following interrelated mechanisms lead to the development of atherosclerosis in patients with SLE5,8–10,20–22,24,32,33: (1) active cellular and humoral immunity result in activation of macrophages, lymphocytes, phagocytes, and neutrophils, CD4+CD28– and CD36 T-cells, and dendritic cells; these cytotoxic cells (either circulating or endovascularly adhered) cause platelets to release platelet-derived growth factors and thromboxane A2 (a vasoconstrictor and platelet activator) and a decrease in endothelial cells’ production of nitric oxide and prostacyclin, all resulting in vasoconstriction and/or thrombosis; (2) cytotoxic cells also produce multiple cytokines (granulocyte or monocyte colony-stimulating factors, interferon-α, ß, or γ, interleukins, tumor necrosis factor-α or ß, and macrophage migration inhibition factor), that are proinflammatory and chemotactic and increase proliferation of smooth muscle cells, and further activate macrophages with release of free radicals, matrix metalloproteinases, and elastase, causing elastin degradation and release of fibroblast growth factors; (3) mononuclear and endothelial cell activation increased production of chemokines (heat shock proteins, C-reactive protein, rheumatoid factor), which recruit inflammatory cells, upregulate endothelial production of vascular and intercellular adhesion molecules, which further promote adhesion of inflammatory cells, vascular smooth-muscle cell proliferation, oxidative stress, endothelial dysfunction and apoptosis, extracellular matrix and collagen deposition; (4) endothelial dysfunction increased production of proinflammatory high-density lipoproteins, oxidative low-density lipoproteins, and activation of the renin-angiotensin system; and (5) SLE disease or steroid therapy-related hypertriglyceridemia, hypercholesterolemia, homocysteinemia, and insulin resistance. These pathogenetic mechanisms result in endothelial dysfunction and apoptosis, smooth muscle cells proliferation, aortic wall hypertrophy and fibrosis, aortic stiffness, increase in arterial impedance, and ultimately in atherosclerosis.

Limitations:

(1) our patient population represents about 30% of ~200 potentially eligible patients from a tertiary care center. Thus, the prevalence of AA found in this study may be an over- or underestimation as compared to that of a general SLE population; (2) limited visualization of the aortic posterior wall by TEE may have led to underestimation of AA; (3) our age- and gender-matched healthy control group was small and therefore may have contributed to an overestimation of the independent effect of SLE on AA; and (4) the cutoff value of 0.87 mm used for defining abnormal IMT may have caused an overestimation of AA. However, the prevalence of AA using a cutoff of > 1 mm showed similar prevalence of abnormal IMT (34% vs 10%, p = 0.04) and an overall similar prevalence of AA among groups (36% vs 10%, p = 0.04; Figure 4).

Figure 4.
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Figure 4.

Aortic atherosclerosis defined as intima media thickening > 1 mm or plaques vs age by group. By multivariate analyses, age and SLE disease were the only independent predictors of AA [OR 1.08 per year of age increment, 95% confidence interval (CI) 1.025–1.4, p = 0.005 for age effect; and OR 6.7, CI 1.28–35, and p = 0.03, for group (SLE) effect]. Note that the probability of AA in patients with SLE was 40% at age 40 and 75% at age 60 as compared to 5% and nearly 35%, respectively, in controls.

Clinical implications of the study:

(1) SLE-associated chronic immune-mediated inflammation may promote premature large-vessel atherosclerosis as it does for medium-size carotid and coronary atherosclerosis; (2) an earlier diagnosis and aggressive antiinflammatory therapy of SLE using noncorticosteroid immunosuppressives may prevent the development and progression of atherosclerosis; (3) AA may play a pathogenic role in peripheral arterial thrombotic or thromboembolic ischemic disease in SLE; (4) subclinical AA may exacerbate aortic stiffness, hypertension, and increased left ventricular mass and diastolic dysfunction in SLE34–36; and (5) antiplatelet and statin therapy may have primary and secondary protective effects in SLE37,38. These diagnostic and therapeutic interventions may decrease the current 2- to 3-fold increased morbidity and mortality of patients with SLE with coronary, cerebrovascular, or peripheral arterial disease. However, a larger cross-sectional and longitudinal study is necessary to better define the short-term and longterm clinical, therapeutic, and prognostic implications of AA in SLE.

Footnotes

  • Supported by the grant RO1 HLO77422-01-A3 from the National Institutes of Health, NHLBI.

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Vol. 37, Issue 1
1 Jan 2010
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Premature Aortic Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Transesophageal Echocardiographic Study
CARLOS A. ROLDAN, JOSEPH JOSON, JANEEN SHARRAR, CLIFFORD R. QUALLS, WILMER L. SIBBITT
The Journal of Rheumatology Jan 2010, 37 (1) 71-78; DOI: 10.3899/jrheum.090665

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Premature Aortic Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Transesophageal Echocardiographic Study
CARLOS A. ROLDAN, JOSEPH JOSON, JANEEN SHARRAR, CLIFFORD R. QUALLS, WILMER L. SIBBITT
The Journal of Rheumatology Jan 2010, 37 (1) 71-78; DOI: 10.3899/jrheum.090665
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