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Research ArticleArticle

Erythrocyte Sedimentation Rate, C-Reactive Protein, or Rheumatoid Factor Are Normal at Presentation in 35%–45% of Patients with Rheumatoid Arthritis Seen Between 1980 and 2004: Analyses from Finland and the United States

TUULIKKI SOKKA and THEODORE PINCUS
The Journal of Rheumatology July 2009, 36 (7) 1387-1390; DOI: https://doi.org/10.3899/jrheum.080770
TUULIKKI SOKKA
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  • For correspondence: tuulikki.sokka@ksshp.fi
THEODORE PINCUS
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Article Figures & Data

Tables

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    Table 1.

    Demographic and clinical status measures at presentation of patients with RA during 1980–2004 in 1892 patients in Jyväskylä, Finland, and 738 patients in Nashville, TN, USA.

    FeatureJyväskyläNashville
    N = 1892No. Patients TestedN = 738No. Patients Tested
    Demographic measures
      Age, yrs, mean (SD)55 (16)189254 (14)738
      No. females, %67189270738
      Race Caucasian, %100189286736
    Clinical measures
      Duration of disease < 1 yr, %72177824729
      Duration of disease, median (IQR)6 (3, 12) months17783.3 (0.9, 11) years729
      Functional disability score on HAQ/MHAQ (0–3)0.88 (0.38, 1.38)10830.87 (0.38, 1.25)730
      Rheumatoid factor, % positive62187463292
      Hemoglobin, g/l131 (122, 140)1853133 (122, 142)437
    ESR, mm/h
        Median (IQR): all patients30 (16, 49)189230 (15, 45)478
        Median (IQR): women30 (17, 50)126730 (15, 47)341
        Median (IQR): men31 (16, 49)62527 (12, 43)137
        ESR < 28 mm/h, %45189247478
      < 30 mm/h for women; < 20 for men
        All patients, %43189245478
        Women, %49126748341
        Men, %3262537137
      ≤ 20 mm/h for women; ≤ 10 for men
        All patients, %25189230143
        Women, %31126733341
        Men, %1462521137
      C-reactive protein, mg/l
        Median (IQR)12 (3, 34)17496 (3, 20)175
        C-reactive protein < 10 mg/l, %44174958175
    • CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; HAQ: Health Assessment Questionnaire; IQR: interquartile range; MHAQ: Multidimensional Health Assessment Questionnaire.

    • View popup
    Table 2.

    Mean and median ESR and CRP Jyväskylä and Nashville in 5-year periods 1980–2004.

    JyväskyläNashville
    MedianMeanNo. of PatientsMedianMeanNo. of Patients
    ESR, mm/h
      1980–198435402193239108
      1985–198931363053135123
      1990–19943339363313790
      1996–20002929508263173
      2000–20042834497282884
      Total303618923035478
    CRP, mg/l
      1980–19842131142NANA0
      1985–1989145280NANA0
      1990–1994152734372123
      1996–200092249461768
      2000–2004112448061877
      Total12251749618168
    • View popup
    Table 3.

    Number (%) at presentation of patients with RA with ESR < or ≥ 28 mm/h in Jyväskylä and in Nashville compared to CRP < or ≥ 10. N = 1744 patients in Jyväskylä; N = 170 patients in Nashville. Data in parentheses are percentages.

    CRPJyväskylä
    ESRTotal
    ≥ 28 mm/h< 28 mm/h
    ≥ 10 mg/l775 (44)202 (12)977 (56)
    < 10 mg/l199 (11)568 (33)767 (44)
    Total974 (56)770 (44)1744 (100)

    CRPNashville
    ESRTotal
    ≥ 28 mm/h< 28 mm/h

    ≥ 10 mg/l48 (28)22 (13)70 (41)
    < 10 mg/l29 (17)71 (42)100 (59)
    Total77 (45)93 (55)170 (100)
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1 Jul 2009
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Erythrocyte Sedimentation Rate, C-Reactive Protein, or Rheumatoid Factor Are Normal at Presentation in 35%–45% of Patients with Rheumatoid Arthritis Seen Between 1980 and 2004: Analyses from Finland and the United States
TUULIKKI SOKKA, THEODORE PINCUS
The Journal of Rheumatology Jul 2009, 36 (7) 1387-1390; DOI: 10.3899/jrheum.080770

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Erythrocyte Sedimentation Rate, C-Reactive Protein, or Rheumatoid Factor Are Normal at Presentation in 35%–45% of Patients with Rheumatoid Arthritis Seen Between 1980 and 2004: Analyses from Finland and the United States
TUULIKKI SOKKA, THEODORE PINCUS
The Journal of Rheumatology Jul 2009, 36 (7) 1387-1390; DOI: 10.3899/jrheum.080770
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