Article Figures & Data
Figures
- Figure 1.
Mean percentage change in Fibromyalgia Impact Questionnaire (FIQ) total (A) and stiffness (B) item scores for each Patient Global Impression of Change (PGIC) category in each study and for all studies pooled. Patients were asked to rate the PGIC at the end of the study as follows: Since the start of the study, my overall status is: 1 = very much improved; 2 = much improved; 3 = minimally improved; 4 = no change; 5 = minimally worse; 6 = much worse; 7 = very much worse.
- Figure 2.
Distribution of patients according the baseline (BL) and endpoint (EP) FIQ severity categories.
Tables
- Table 1.
Minimal clinically important difference, calculated as clinically important percentage change (95% CI) in the Fibromyalgia Impact Questionnaire (FIQ) total and FIQ stiffness item scores (pooled data).
FIQ Total, % (95% CI) FIQ Stiffness, % (95% CI) Study 1 15.0 (13.9; 16.0) 13.9 (2.4; 13.4) Study 2 11.6 (9.8; 13.4) 10.5 (8.1; 12.7) Study 3 12.9 (11.4; 14.3) 13.3 (0.7; 25.7) Pooled 14.1 (13.3; 14.3) 13.2 (11.9; 14.4) - Table 2.
Fibromyalgia Impact Questionnaire (FIQ) total score severity categorization using pain severity as an anchor (pooled data).
Pain Severity (anchor) FM Impairment Category FIQ Total Score < 3.5 Mild impairment < 39 3.5–6.5 Moderate impairment ≥ 39 to < 59 ≥ 6.5 Severe impairment ≥ 59 - Table 3.
For each of the 3 pregabalin treatment groups and the placebo group: percentages of subjects according to Fibromyalgia Impact Questionnaire severity category at endpoint and difference from placebo. CI: confidence interval.
Severity Placebo n = 558 300 mg Group, n = 551 450 mg Group, n = 554 600 mg Group, n = 564 Mild Percentage 26.88 27.77 34.30 32.62 Difference from placebo (95% CI) — 0.89 (−4.37; 6.14) 7.42 (2.17; 12.9) 5.74 (0.44; 11.09) Moderate Percentage 32.44 36.48 35.02 34.04 Difference from placebo (95% CI) — 4.04 (−1.56; 9.66) 2.58 (−3.05; 8.07) 1.6 (−3.83; 7.04) Severe Percentage 40.68 35.75 30.69 33.33 Difference from placebo (95% CI) — –4.93 (−10.7; 0.77) –9.99 (−15.63; −4.47) –7.35 (−12.96; −1.69)
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