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Review ArticleReview

Land-based Exercise for Osteoarthritis of the Knee: A Metaanalysis of Randomized Controlled Trials

MARLENE FRANSEN and SARA McCONNELL
The Journal of Rheumatology June 2009, 36 (6) 1109-1117; DOI: https://doi.org/10.3899/jrheum.090058
MARLENE FRANSEN
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SARA McCONNELL
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    Figure 1.

    All randomized controlled trials: knee pain outcome. Mean change, standard deviation, sample size for treatment and control groups.

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    Figure 2.

    All randomized controlled trials: physical function outcome. Mean change, standard deviation, sample size for treatment and control groups.

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    Table 1.

    Effect size estimates for knee pain and physical function. Subgroup comparisons.

    Outcome and SubgroupRCT, nParticipants, nEffect Estimate SMD (95% CI)Chi-square for Distribution (p)
    1. Knee pain3236160.40 (0.30–0.50)
      Delivery mode
        Individual108490.55 (0.29–0.81)
        Classes1716080.37 (0.24–0.51)NS
        Home program612600.28 (0.16–0.39)
      Direct supervision
        Less than 12 occasions915940.28 (0.16–0.40)
        12 or more occasions2320220.46 (0.32–0.60)4.82 (0.03)
      Outcomes assessment
        Blinded1825590.33 (0.22–0.43)
        Unblinded/uncertain1410570.53 (0.33–0.73)5.64 (0.02)
      Analysis method
        Intention to treat1423940.36 (0.21–0.51)
        Efficacy1812220.45 (0.32–0.58)NS
      Allocation concealment
        Adequate1425990.33 (0.23–0.44)
        Unclear/inadequate1812020.49 (0.32–0.66)3.94 (0.05)
      Risk of estimate bias
        Low1020210.28 (0.15–0.42)
        Moderate139720.48 (0.29–0.67)
        High96230.51 (0.30–0.72)7.98 (0.02)
    2. Physical function3138200.36 (0.25–0.48)
      Delivery mode
        Individual108490.52 (0.19–0.86)
        Classes1615630.35 (0.19–0.50)
        Home program614080.28 (0.17–0.38)NS
      Direct supervision
        Less than 12 occasions917310.23 (0.09–0.37)
        12 or more occasions2219880.45 (0.29–0.62)5.52 (0.02)
      Outcomes assessment
        Blinded1927300.28 (0.17–0.39)
        Unblinded/uncertain129890.55 (0.28–0.83)7.21 (0.01)
      Analysis method
        Intention to treat1525760.30 (0.16–0.45)
        Efficacy1611430.43 (0.23–0.64)NS
      Allocation concealment
        Adequate1525960.28 (0.18–0.38)
        Unclear/inadequate1611230.48 (0.23–0.73)4.71 (0.03)
      Risk of estimate bias
        Low1020240.25 (0.13–0.38)
        Moderate1411400.39 (0.18–0.60)
        High75550.55 (0.21–0.90)8.98 (0.01)
    • RCT: randomized controlled trial; SMD: standardized mean difference.

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1 Jun 2009
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Land-based Exercise for Osteoarthritis of the Knee: A Metaanalysis of Randomized Controlled Trials
MARLENE FRANSEN, SARA McCONNELL
The Journal of Rheumatology Jun 2009, 36 (6) 1109-1117; DOI: 10.3899/jrheum.090058

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Land-based Exercise for Osteoarthritis of the Knee: A Metaanalysis of Randomized Controlled Trials
MARLENE FRANSEN, SARA McCONNELL
The Journal of Rheumatology Jun 2009, 36 (6) 1109-1117; DOI: 10.3899/jrheum.090058
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