Abstract
Objective. To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.
Methods. In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.
Results. 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93–1.63).
Conclusion. Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.
Footnotes
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Supported by the National Institutes of Health Autoimmunity Prevention Center grants U-19 AI050864, R-01AR051394; grants MO1 RR00069, MO1 RR00425, General Clinical Research Centers Program, National Center for Research Resources, NIH; and a Research Support Fund grant from the Nebraska Medical Center and the University of Nebraska Medical Center.
- Accepted for publication November 10, 2008.
