Article Figures & Data
Figures
- Figure 1.
A. An adult patient with Grade 1 KBD; the knuckles are plainly thickened. B. Brachydactylia abnormality of a patient with Grade 2 KBD.
- Figure 2.
Chromatograms of unsaturated disaccharides on HPLC. A. Standard unsaturated disaccharides. B. Unsaturated disaccharides purified from human urine. Horizontal axis represents retention time (min), each peak is integrated by peak area. Retention times of ΔDi-0S, ΔDi-4S, and ΔDi-6S are 6.740 min, 16.757 min, and 18.690 min, respectively.
Tables
Group N Age Interval Mean Age, yrs N Men
Age, yrsMean N Women
Age, yrsMean Control 25 42–69 53.20 14 44–69 54.97 11 42–62 51.18 Grade 1 33 41–75 50.97 16 42–75 53.56 17 41–56 48.53 Grade 2 22 40–74 52.82 17 40–74 52.41 5 43–74 54.20 Total 80 40–75 52.18 47 40–75 53.51 33 41–74 50.27 -
The age and sex matches of the subgroups are close, except there are fewer female patients of Grade 2 group.
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- Table 2.
The means and F values of 3 unsaturated disaccharides, PYD/CR, and HYP/CR in the 3 study groups.
Marker Group N Mean (SD) F ΔDi-0S†, μg/ml Control 22 1.123 (0.204) 85.700** Grade 1 29 1.177 (0.286) Grade 2 21 2.045 (0.285) ΔDi-4S†, μg/ml Control 22 0.838 (0.206) 19.609** Grade 1 29 0.847 (0.331) Grade 2 21 1.320 (0.316) ΔDi-6S†, μg/ml Control 22 0.930 (0.102) 13.855** Grade 1 29 1.014 (0.347) Grade 2 21 1.381 (0.366) PYD/CR†† Control 24 0.117 (0.092) 3.431* Grade 1 33 0.100 (0.106) Grade 2 20 0.310 (0.566) HYP/CR Control 25 0.010 (0.006) 0.072 Grade 1 33 0.009 (0.011) Grade 2 22 0.009 (0.008) PYD/CR HYP/CR ΔDi-0S ΔDi-4S ΔDi-6S PYD/CR 1.000 0.470** 0.113 0.122 0.069 HYP/CR 0.470** 1.000 –0.061 0.004 –0.024 ΔDi-0S 0.113 –0.061 1.000 0.572** 0.576** ΔDi-4S 0.122 0.004 0.572** 1.000 0.341** ΔDi-6S 0.069 –0.024 0.576** 0.341** 1.000 -
* Significant at the 0.01 level (2-tailed).
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In this issue
Detection of Unsaturated Disaccharides, Pyridinoline, and Hydroxyproline in Urine of Patients with Kashin-Beck Disease: Comparison with Controls in an Endemic Area
