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Research ArticleArticle

Circulating Leptin and Adiponectin Concentrations During Tumor Necrosis Factor Blockade in Patients with Active Rheumatoid Arthritis

CALIN POPA, MIHAI G. NETEA, JACQUELINE de GRAAF, FRANK H.J. van den HOOGEN, TIMOTHY R.D.J. RADSTAKE, HELGA TOENHAKE-DIJKSTRA, PIET L.C.M. van RIEL, JOS W.M. van der MEER, ANTON F.H. STALENHOEF and PILAR BARRERA
The Journal of Rheumatology April 2009, 36 (4) 724-730; DOI: https://doi.org/10.3899/jrheum.080626
CALIN POPA
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  • For correspondence: c.popa@reuma.umcn.nl
MIHAI G. NETEA
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JACQUELINE de GRAAF
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FRANK H.J. van den HOOGEN
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TIMOTHY R.D.J. RADSTAKE
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HELGA TOENHAKE-DIJKSTRA
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PIET L.C.M. van RIEL
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JOS W.M. van der MEER
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ANTON F.H. STALENHOEF
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PILAR BARRERA
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Abstract

Objective. Adipocytokines, including leptin and adiponectin, may play an important role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of longterm therapeutic tumor necrosis factor (TNF) blockade on adipocytokine concentrations in patients with RA.

Methods. We studied 58 RA patients starting anti-TNF therapy and 58 healthy controls matched for age, sex, and body mass index (BMI). Fasting blood samples were drawn at baseline, 2 weeks, and 6 months after the start of anti-TNF therapy and serum levels of leptin and adiponectin were measured.

Results. Patients with RA had increased adiponectin (p < 0.001) and similar leptin concentrations compared with the controls. Leptin concentrations were significantly higher in patients with high BMI (p < 0.001) and correlated positively with BMI at all timepoints (r > 0.75). In contrast, serum adiponectin tended to be higher in lean RA patients and did not correlate with BMI at any timepoint. There were no clear correlations between serum concentrations of adipocytokines and disease activity (Disease Activity Score 28). Short or longterm TNF blockade alone had no influence on circulating leptin and adiponectin concentrations. Patients treated with anti-TNF and concomitant corticosteroids on a stable basis showed a significant decrease in adiponectin levels after 6 months of therapy (p < 0.025).

Conclusion. In patients with RA, chronic inflammation and its suppression during anti-TNF therapy have limited influence on plasma leptin concentrations, while significantly decreasing circulating adiponectin levels. Our findings question the suggested key role of inflammatory markers in regulating adipocytokine patterns in RA.

  • LEPTIN
  • ADIPONECTIN
  • TUMOR NECROSIS FACTOR BLOCKADE
  • RHEUMATOID ARTHRITIS

Footnotes

  • Dr. Popa was supported by “De Drie Lichten” Foundation, The Netherlands. Dr. Netea was supported by a VIDI Grant from the Netherlands Organization for Scientific Research (NWO).

    • Accepted for publication November 27, 2008.
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The Journal of Rheumatology
Vol. 36, Issue 4
1 Apr 2009
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Circulating Leptin and Adiponectin Concentrations During Tumor Necrosis Factor Blockade in Patients with Active Rheumatoid Arthritis
CALIN POPA, MIHAI G. NETEA, JACQUELINE de GRAAF, FRANK H.J. van den HOOGEN, TIMOTHY R.D.J. RADSTAKE, HELGA TOENHAKE-DIJKSTRA, PIET L.C.M. van RIEL, JOS W.M. van der MEER, ANTON F.H. STALENHOEF, PILAR BARRERA
The Journal of Rheumatology Apr 2009, 36 (4) 724-730; DOI: 10.3899/jrheum.080626

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Circulating Leptin and Adiponectin Concentrations During Tumor Necrosis Factor Blockade in Patients with Active Rheumatoid Arthritis
CALIN POPA, MIHAI G. NETEA, JACQUELINE de GRAAF, FRANK H.J. van den HOOGEN, TIMOTHY R.D.J. RADSTAKE, HELGA TOENHAKE-DIJKSTRA, PIET L.C.M. van RIEL, JOS W.M. van der MEER, ANTON F.H. STALENHOEF, PILAR BARRERA
The Journal of Rheumatology Apr 2009, 36 (4) 724-730; DOI: 10.3899/jrheum.080626
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