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Research ArticleArticle

Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study

TUHINA NEOGI, R. CURTIS ELLISON, STEVEN HUNT, ROBERT TERKELTAUB, DAVID T. FELSON and YUQING ZHANG
The Journal of Rheumatology February 2009, 36 (2) 378-384; DOI: https://doi.org/10.3899/jrheum.080646
TUHINA NEOGI
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  • For correspondence: tneogi@bu.edu
R. CURTIS ELLISON
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STEVEN HUNT
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ROBERT TERKELTAUB
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DAVID T. FELSON
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YUQING ZHANG
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Abstract

Objective. To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors.

Methods. The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia.

Results In total, 4866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, ≥ 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women.

Conclusion. In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men.

Key Indexing Terms:
  • URIC ACID
  • CAROTID ATHEROSCLEROSIS
  • RISK FACTORS
  • EPIDEMIOLOGY

Footnotes

  • Supported by the American College of Rheumatology–Research and Education Fund (ACR-REF); Arthritis Foundation; National Institutes of Health (NIH) AR 47785; National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement grants U01 HL56563, U01 HL56564, U01 HL56565, U01 HL56566, U01 HL56567, U01 HL56568, and U01 HL56569; NIH HL077360; Veterans Affairs (VA); and TAP Pharmaceuticals. Dr. Neogi is supported by an ACR-REF/Association of Specialty Physicians (ASP) Junior Career Development Award in Geriatric Medicine, Arthritis Foundation Arthritis Investigator Award, and NIH (NIAMS) 1K23AR055127.

    • Accepted for publication September 4, 2008.
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The Journal of Rheumatology
Vol. 36, Issue 2
1 Feb 2009
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Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study
TUHINA NEOGI, R. CURTIS ELLISON, STEVEN HUNT, ROBERT TERKELTAUB, DAVID T. FELSON, YUQING ZHANG
The Journal of Rheumatology Feb 2009, 36 (2) 378-384; DOI: 10.3899/jrheum.080646

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Serum Uric Acid Is Associated with Carotid Plaques: The National Heart, Lung, and Blood Institute Family Heart Study
TUHINA NEOGI, R. CURTIS ELLISON, STEVEN HUNT, ROBERT TERKELTAUB, DAVID T. FELSON, YUQING ZHANG
The Journal of Rheumatology Feb 2009, 36 (2) 378-384; DOI: 10.3899/jrheum.080646
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