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Research ArticleArticle

Health-Related Quality of Life: Validity, Reliability, and Responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in Patients with Rheumatoid Arthritis

LOUISE LINDE, JAN SØRENSEN, MIKKEL ØSTERGAARD, KIM HØRSLEV-PETERSEN and MERETE LUND HETLAND
The Journal of Rheumatology August 2008, 35 (8) 1528-1537;
LOUISE LINDE
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  • For correspondence: louiselinde@dadlnet.dk
JAN SØRENSEN
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MIKKEL ØSTERGAARD
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KIM HØRSLEV-PETERSEN
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MERETE LUND HETLAND
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Abstract

Objective

To compare validity, reliability, and responsiveness of generic and disease specific health-related quality of life (HRQOL) instruments in rheumatoid arthritis (RA).

Methods

Two samples of patients completed the Medical Outcomes Study Short Form-36 Health Survey (SF-36), EuroQol (EQ)-5D, 15D, Rheumatoid Arthritis Quality of Life Scale (RAQoL), Health Assessment Questionnaire (HAQ), and visual analog scales (VAS) for pain, fatigue, and global RA. Validity (convergent, discriminant, and known-groups) was evaluated in a cross-section of 200 patients. Reliability was evaluated by agreement (intraclass correlation coefficient; baseline to 2 weeks) and internal consistency (Cronbach’s alpha); and responsiveness by the standardized response mean stratified on improvement, status quo, or deterioration in health status after 6 months in 150 patients followed longitudinally. Followup questionnaires (at 2 weeks and 6 months) included questions about changes in health status since baseline.

Results

The cross-sectional sample included 77% women, median age 57 years (range 19–87), disease duration 6 years (0–58), with Disease Activity Score 28-joint count (DAS28) of 3.10 (1.21–6.47). The longitudinal sample included 80% women, median age 60 years (22–82). Validity: all instruments discriminated between low, moderate, and high DAS28. Reliability: RAQoL and HAQ displayed good repeatability (ICC > 0.95) and internal consistency (Cronbach’s alpha > 0.90). Responsiveness: SF-36 bodily pain scale and VAS pain were responsive to both improvement and deterioration.

Conclusion

All instruments were valid measures for HRQOL in RA. The RAQoL and HAQ displayed the best reliability, while the SF-36 bodily pain scale and VAS pain were the most responsive. The choice of instrument should depend on the study objectives.

Key Indexing Terms:
  • RHEUMATOID ARTHRITIS
  • HEALTH-RELATED QUALITY OF LIFE
  • VALIDITY
  • RELIABILITY
  • RESPONSIVENESS

Footnotes

  • L. Linde, MD; M. Østergaard, MD, PhD, DMSc; M.L. Hetland, MD, PhD, Department of Rheumatology at Copenhagen University Hospital; J. Sørensen, MSc, CAST, University of Southern Denmark; K. Hørslev-Petersen, MD, DMSc, Gråsten Gigthospital.

    • Accepted for publication February 7, 2008.
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The Journal of Rheumatology
Vol. 35, Issue 8
1 Aug 2008
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Health-Related Quality of Life: Validity, Reliability, and Responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in Patients with Rheumatoid Arthritis
LOUISE LINDE, JAN SØRENSEN, MIKKEL ØSTERGAARD, KIM HØRSLEV-PETERSEN, MERETE LUND HETLAND
The Journal of Rheumatology Aug 2008, 35 (8) 1528-1537;

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Health-Related Quality of Life: Validity, Reliability, and Responsiveness of SF-36, EQ-15D, EQ-5D, RAQoL, and HAQ in Patients with Rheumatoid Arthritis
LOUISE LINDE, JAN SØRENSEN, MIKKEL ØSTERGAARD, KIM HØRSLEV-PETERSEN, MERETE LUND HETLAND
The Journal of Rheumatology Aug 2008, 35 (8) 1528-1537;
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