Abstract
Psoriasis and psoriatic arthritis (PsA) both have substantive genetic determinants. Numerous candidate regions and genes have now been replicated in disease susceptibility, and to a lesser extent in disease expression, in both disease entities. Intensive efforts are now under way or are being planned to perform genome-wide association scans (GWAS) in psoriasis and PsA. A major determinant of success for GWAS is likely to be accumulation of multiple large well-phenotyped cohorts, sophisticated data management, and verification of the findings. At the 2007 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members of the GRAPPA genetics committee presented a discussion of the genetics of psoriasis and PsA, including future trends. This article is a summary of that presentation and a review of the literature.
Key Indexing Terms:Footnotes
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Supported by an unrestricted financial grant from Abbott, Centocor, Wyeth, Amgen, and UCB Pharma. V. Chandran is supported by Canadian Arthritis Network and Arthritis and Autoimmunitity Research Centre Foundation, Toronto.
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K.C. Duffin, MD, Department of Dermatology, University of Utah; V. Chandran, MBBS, MD, DM, University of Toronto Psoriatic Arthritis Clinic, University Health Network, University of Toronto; D.D. Gladman, MD, FRCPC, University of Toronto and Toronto Western Research Institute, University of Toronto; G.G. Krueger, MD, Department of Dermatology, University of Utah; J.T. Elder, MD, PhD, University of Michigan and Ann Arbor Veterans Affairs Health System; P. Rahman, MD, MSc, Department of Medicine, Division of Rheumatology, Memorial University.
