Efficacy of Infliximab in Cogan’s Syndrome

Excerpt

To the Editor:

Cogan’s syndrome is a rare chronic inflammatory disease that most commonly affects adults in the third decade, with no gender predominance. Interstitial keratitis is the characteristic ocular feature, although this is not mandatory for the diagnosis; moreover, ocular manifestations such as scleritis, episcleritis, and uveitis may occur. The vestibuloauditory manifestations consist of a Ménière’s-like disease including vertigo, nausea, vomiting, tinnitus, and hearing loss. The diagnosis is made upon the association of eye disease and vestibuloauditory dysfunction, with or without systemic features (fever, asthenia, weight loss, arthritis, arthralgias, aortitis, and abdominal pain)^1–4.

A 48-year-old woman was admitted...