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LetterLetter

Blockade of Interleukin 1 Receptor in Still’s Disease Affects Activation of Peripheral T-Lymphocytes

JIHAD YOUSSEF, ESTIBALIZ LAZARO, PATRICK BLANCO and JEAN-FRANÇOIS VIALLARD
The Journal of Rheumatology December 2008, 35 (12) 2453-2456; DOI: https://doi.org/10.3899/jrheum.080150
JIHAD YOUSSEF
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ESTIBALIZ LAZARO
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PATRICK BLANCO
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JEAN-FRANÇOIS VIALLARD
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  • For correspondence: jean-francois.viallard@chu-bordeaux.fr
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To the Editor:

Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disease characterized by arthralgias, transient cutaneous eruption, and high fluctuating fever1. No pathognomonic biological marker has yet been identified, making diagnosis difficult.

Recent pathophysiological findings showed thatAOSD is characterized by a particular cytokine profile, suggesting implication of Th1 immune response. The overwhelming implication of interleukin 1 (IL-1) in the systemic inflammatory reaction seen during the course of AOSD has justified the administration of agents blocking IL-1 receptor (anakinra), which gave some good results3,4. We describe a case of AOSD with an activated macrophage syndrome that responded to anakinra.…

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    Vol. 35, Issue 12
    1 Dec 2008
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    Blockade of Interleukin 1 Receptor in Still’s Disease Affects Activation of Peripheral T-Lymphocytes
    JIHAD YOUSSEF, ESTIBALIZ LAZARO, PATRICK BLANCO, JEAN-FRANÇOIS VIALLARD
    The Journal of Rheumatology Dec 2008, 35 (12) 2453-2456; DOI: 10.3899/jrheum.080150

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    Blockade of Interleukin 1 Receptor in Still’s Disease Affects Activation of Peripheral T-Lymphocytes
    JIHAD YOUSSEF, ESTIBALIZ LAZARO, PATRICK BLANCO, JEAN-FRANÇOIS VIALLARD
    The Journal of Rheumatology Dec 2008, 35 (12) 2453-2456; DOI: 10.3899/jrheum.080150
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