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Research ArticleArticle

Elevated Serum Insulin-like Growth Factor (IGF-1) and IGF Binding Protein-3 Levels in Patients with Systemic Sclerosis: Possible Role in Development of Fibrosis

YASUHITO HAMAGUCHI, MANABU FUJIMOTO, TAKASHI MATSUSHITA, MINORU HASEGAWA, KAZUHIKO TAKEHARA and SHINICHI SATO
The Journal of Rheumatology December 2008, 35 (12) 2363-2371; DOI: https://doi.org/10.3899/jrheum.080340
YASUHITO HAMAGUCHI
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MANABU FUJIMOTO
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  • For correspondence: mfujimoto@derma.m.kanazawa-u.ac.jp
TAKASHI MATSUSHITA
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MINORU HASEGAWA
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KAZUHIKO TAKEHARA
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SHINICHI SATO
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Abstract

Objective

To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic sclerosis (SSc); and to relate the results to clinical features in SSc.

Methods

Serum IGF-1 and IGFBP-3 levels in 92 Japanese patients with SSc were measured by ELISA. Expression of IGF-1 and IGFBP-3 messenger RNA (mRNA) in the skin was quantified by real-time reverse transcription-polymerase chain reaction.

Results

Serum IGF-1 and IGFBP-3 levels were significantly elevated in patients with SSc compared with patients with systemic lupus erythematosus or healthy controls. IGF-1 levels were higher in patients with diffuse cutaneous SSc (dcSSc) than in patients with limited cutaneous SSc (lcSSc). Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis. IGF- 1 mRNA was upregulated in the affected skin of patients with SSc. There were no significant differences in serum IGFBP-3 levels between dcSSc and lcSSc. IGFBP-3 levels were not associated with skin thickness and pulmonary fibrosis. Patients with increased IGF-1 or IGFBP-3 had lower frequency of telangiectasia than patients with normal levels.

Conclusion

These results suggest that both IGF-1 and IGFBP-3 are involved in the development of SSc. The role of IGF-1 appears to be different from that of IGFBP-3.

Key Indexing Terms:
  • SYSTEMIC SCLEROSIS
  • INSULIN-LIKE GROWTH FACTOR
  • INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN
  • TOTAL SKIN THICKNESS SCORE

Footnotes

  • Y. Hamaguchi, MD, PhD; M. Fujimoto, MD; T. Matsushita, MD, PhD; M. Hasegawa, MD, PhD; K. Takehara, MD, PhD, Department of Dermatology, Kanazawa University Graduate School of Medical Science; S. Sato, MD, PhD, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences.

  • Supported by a grant to Dr. Fujimoto for research on intractable diseases from the Ministry of Health, Labour and Welfare of Japan.

    • Accepted for publication August 14, 2008.
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The Journal of Rheumatology
Vol. 35, Issue 12
1 Dec 2008
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Elevated Serum Insulin-like Growth Factor (IGF-1) and IGF Binding Protein-3 Levels in Patients with Systemic Sclerosis: Possible Role in Development of Fibrosis
YASUHITO HAMAGUCHI, MANABU FUJIMOTO, TAKASHI MATSUSHITA, MINORU HASEGAWA, KAZUHIKO TAKEHARA, SHINICHI SATO
The Journal of Rheumatology Dec 2008, 35 (12) 2363-2371; DOI: 10.3899/jrheum.080340

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Elevated Serum Insulin-like Growth Factor (IGF-1) and IGF Binding Protein-3 Levels in Patients with Systemic Sclerosis: Possible Role in Development of Fibrosis
YASUHITO HAMAGUCHI, MANABU FUJIMOTO, TAKASHI MATSUSHITA, MINORU HASEGAWA, KAZUHIKO TAKEHARA, SHINICHI SATO
The Journal of Rheumatology Dec 2008, 35 (12) 2363-2371; DOI: 10.3899/jrheum.080340
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