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Research ArticleArticle

A Comparison of Calcium, Calcitriol, and Alendronate in Corticosteroid-Treated Premenopausal Patients with Systemic Lupus Erythematosus

SWAN S. YEAP, AHMAD R. FAUZI, NORELLA C.T. KONG, ABDUL G. HALIM, ZAINUDIN SOEHARDY, ISMAIL RAHIMAH, SOOK K. CHOW and EMILY M.L. GOH
The Journal of Rheumatology December 2008, 35 (12) 2344-2347; DOI: https://doi.org/10.3899/jrheum.080634
SWAN S. YEAP
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  • For correspondence: yeapss@myjaring.net
AHMAD R. FAUZI
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NORELLA C.T. KONG
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ABDUL G. HALIM
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ZAINUDIN SOEHARDY
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ISMAIL RAHIMAH
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SOOK K. CHOW
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EMILY M.L. GOH
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Abstract

Objective

To assess bone mineral density (BMD) changes in patients with systemic lupus erythematosus (SLE) undergoing longterm therapy with corticosteroids (CS) while taking calcium, calcitriol, or alendronate. The primary endpoint was BMD changes at 2 years.

Methods

Premenopausal SLE patients were randomized into 3 groups according to medication: calcium carbonate 500 mg bd (calcium alone), calcitriol 0.25 μg bd plus calcium carbonate 500 mg bd (calcitriol + calcium), and alendronate 70 mg/week plus calcium carbonate 500 mg bd (alendronate + calcium). BMD was measured at baseline and at the end of the first and second years.

Results

Ninety-eight patients were recruited. There were 33 patients taking calcium alone, 33 calcitriol + calcium, and 32 alendronate + calcium. On randomization, median duration of CS use was 2.5 years (range 0–20 yrs). Seventy-seven patients (78.6%) completed the study (23 taking calcium alone, 27 calcitriol + calcium, 27 alendronate + calcium). There were no significant differences in mean CS dosages among the 3 groups at the time of BMD measurements. After 2 years, there were no significant changes in BMD in the calcium-alone and calcitriol + calcium groups, apart from a 0.93% (p < 0.001) reduction in total hip BMD in the calcium-alone group. In contrast, the alendronate + calcium group showed significant increases in BMD of 2.69% (p < 0.001) in the lumbar spine and 1.41% (p < 0.001) in total hip.

Conclusion

Both calcium alone and calcitriol + calcium preserved lumbar spine BMD in premenopausal patients with SLE taking longterm CS at 2 years, whereas alendronate + calcium led to increases in BMD in lumbar spine and total hip. Premenopausal women taking CS should be considered for osteoporosis prophylaxis.

Key Indexing Terms:
  • OSTEOPOROSIS
  • GLUCOCORTICOID
  • SYSTEMIC LUPUS ERYTHEMATOSUS
  • PREMENOPAUSAL
  • ALENDRONATE
  • CALCITRIOL

Footnotes

  • S.S. Yeap, FRCP(Ed), FRCP(London), Consultant Rheumatologist, Department of Medicine, Faculty of Medicine, University of Malaya; A.R. Fauzi, MRCP(UK); N.C.T. Kong, FRACP, FRCP(Ed); A.G. Halim, MMed; Z. Soehardy, MRCP(UK); I. Rahimah, RN, Department of Medicine, Hospital University Kebangsaan Malaysia, University Kebangsaan Malaysia; S.K. Chow, FRCP(London); E.M.L. Goh, MRCP(UK), Department of Medicine, Faculty of Medicine, University of Malaya.

  • Supported by a Medical School Grant from Merck & Co., Inc., Whitehouse Station, NJ, USA, and a research grant from Roche (Malaysia) Sdn. Bhd.

    • Accepted for publication July 31, 2008.
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The Journal of Rheumatology
Vol. 35, Issue 12
1 Dec 2008
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A Comparison of Calcium, Calcitriol, and Alendronate in Corticosteroid-Treated Premenopausal Patients with Systemic Lupus Erythematosus
SWAN S. YEAP, AHMAD R. FAUZI, NORELLA C.T. KONG, ABDUL G. HALIM, ZAINUDIN SOEHARDY, ISMAIL RAHIMAH, SOOK K. CHOW, EMILY M.L. GOH
The Journal of Rheumatology Dec 2008, 35 (12) 2344-2347; DOI: 10.3899/jrheum.080634

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A Comparison of Calcium, Calcitriol, and Alendronate in Corticosteroid-Treated Premenopausal Patients with Systemic Lupus Erythematosus
SWAN S. YEAP, AHMAD R. FAUZI, NORELLA C.T. KONG, ABDUL G. HALIM, ZAINUDIN SOEHARDY, ISMAIL RAHIMAH, SOOK K. CHOW, EMILY M.L. GOH
The Journal of Rheumatology Dec 2008, 35 (12) 2344-2347; DOI: 10.3899/jrheum.080634
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