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LetterCorrespondence

Parotid Irrigation and Cevimeline Gargle for Treatment of Xerostomia in Sjögren’s Syndrome

YUKINORI TAKAGI, IKUO KATAYAMA, SHIGEKI TASHIRO and TAKASHI NAKAMURA
The Journal of Rheumatology November 2008, 35 (11) 2289-2291; DOI: https://doi.org/10.3899/jrheum.080370
YUKINORI TAKAGI
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IKUO KATAYAMA
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SHIGEKI TASHIRO
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TAKASHI NAKAMURA
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To the Editor:

Xerostomia may be associated with a wide range of diseases including autoimmune diseases such as Sjögren’s syndrome (SS)1. Cholinergic agents such as pilocarpine and cevimeline have been recently applied to relieve xerostomia in patients with SS. However, adverse effects such as abdominal pain, nausea, diarrhea, and ocular symptoms were major shortcomings in the use of the drugs2,3.

Corticosteroid irrigation of the affected salivary glands has been successfully applied to patients with SS4. Further, a preliminary study showed that cevimeline gargle was effective in treating some patients with severe SS who were refractory to treatment with corticosteroid irrigation5...

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    Vol. 35, Issue 11
    1 Nov 2008
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    Parotid Irrigation and Cevimeline Gargle for Treatment of Xerostomia in Sjögren’s Syndrome
    YUKINORI TAKAGI, IKUO KATAYAMA, SHIGEKI TASHIRO, TAKASHI NAKAMURA
    The Journal of Rheumatology Nov 2008, 35 (11) 2289-2291; DOI: 10.3899/jrheum.080370

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    Parotid Irrigation and Cevimeline Gargle for Treatment of Xerostomia in Sjögren’s Syndrome
    YUKINORI TAKAGI, IKUO KATAYAMA, SHIGEKI TASHIRO, TAKASHI NAKAMURA
    The Journal of Rheumatology Nov 2008, 35 (11) 2289-2291; DOI: 10.3899/jrheum.080370
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