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LetterCorrespondence

Etanercept-associated Pulmonary Granulomatous Inflammation in Patients with Rheumatoid Arthritis

VLADIMIR M. OGNENOVSKI, TAMMY CLARK OJO and DAVID A. FOX
The Journal of Rheumatology November 2008, 35 (11) 2279-2282; DOI: https://doi.org/10.3899/jrheum.080383
VLADIMIR M. OGNENOVSKI
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TAMMY CLARK OJO
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DAVID A. FOX
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To the Editor:

We describe 4 patients with rheumatoid arthritis (RA) who developed noninfectious pulmonary granulomatous disease while treated with etanercept (Table 1).All patients improved with withdrawal of etanercept and addition of prednisone, without use of antibiotic, antifungal, or antimycobacterial medications. They were subsequently treated with adalimumab with no recurrence of pulmonary toxicity.

Patient 1. After an inadequate response to leflunomide, a 60-year-old man with 1 year of seropositive RA started etanercept, with subsequent improvement. He then experienced progressive malaise and a 40-lb weight loss. Chest radiograph and computed tomography (CT) scan revealed multiple pulmonary nodules bilaterally. Open-lung biopsy demonstrated ...

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    Vol. 35, Issue 11
    1 Nov 2008
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    Etanercept-associated Pulmonary Granulomatous Inflammation in Patients with Rheumatoid Arthritis
    VLADIMIR M. OGNENOVSKI, TAMMY CLARK OJO, DAVID A. FOX
    The Journal of Rheumatology Nov 2008, 35 (11) 2279-2282; DOI: 10.3899/jrheum.080383

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    Etanercept-associated Pulmonary Granulomatous Inflammation in Patients with Rheumatoid Arthritis
    VLADIMIR M. OGNENOVSKI, TAMMY CLARK OJO, DAVID A. FOX
    The Journal of Rheumatology Nov 2008, 35 (11) 2279-2282; DOI: 10.3899/jrheum.080383
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