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Research ArticleArticle

Different Genetic Effects of Interferon Regulatory Factor 5 (IRF5) Polymorphisms on Systemic Lupus Erythematosus in a Korean Population

HYOUNG DOO SHIN, IL KIM, CHAN-BUM CHOI, SOO OK LEE, HYE WON LEE and SANG-CHEOL BAE
The Journal of Rheumatology November 2008, 35 (11) 2148-2151; DOI: https://doi.org/10.3899/jrheum.080124
HYOUNG DOO SHIN
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IL KIM
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CHAN-BUM CHOI
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SOO OK LEE
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HYE WON LEE
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SANG-CHEOL BAE
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  • For correspondence: scbae@hanyang.ac.kr
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Abstract

Objective

In an effort to replicate additional associations of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erythematosus (SLE) in an Asian population, we examined those genetic effects in a Korean SLE cohort.

Methods

Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE.

Results

Three single-nucleotide polymorphisms (IRF5-15-1, rs2070197, and rs10488631), which showed strong and/or independent association in Caucasian populations, were not polymorphic in our Korean population. Association analysis revealed different genetic effects in Koreans compared with Caucasian populations. In addition, conditional analysis suggested independent genetic effects of 3 variant groups in the Korean population.

Conclusion

We demonstrate different genetic effects of IRF5 polymorphisms on the risk of SLE according to ethnicity.

Key Indexing Terms:
  • INTERFERON REGULATORY FACTOR 5
  • POLYMORPHISM
  • SYSTEMIC LUPUS ERYTHEMATOSUS

Footnotes

  • H.D. Shin, PhD, Laboratory of Genomic Diversity, Department of Life Science, Sogang University, and Department of Genetic Epidemiology, SNP Genetics Inc.; S.O. Lee, MS; H.W. Lee, MS, Department of Genetic Epidemiology, SNP Genetics, Inc.; I. Kim, MD; C-B. Choi, MD; S-C. Bae, MD, PhD, MPH, Department of Rheumatology, the Hospital for Rheumatic Diseases, Hanyang University.

  • Supported in part by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ3-PG6-01GN11-0002).

    • Accepted for publication July 3, 2008.
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The Journal of Rheumatology
Vol. 35, Issue 11
1 Nov 2008
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Different Genetic Effects of Interferon Regulatory Factor 5 (IRF5) Polymorphisms on Systemic Lupus Erythematosus in a Korean Population
HYOUNG DOO SHIN, IL KIM, CHAN-BUM CHOI, SOO OK LEE, HYE WON LEE, SANG-CHEOL BAE
The Journal of Rheumatology Nov 2008, 35 (11) 2148-2151; DOI: 10.3899/jrheum.080124

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Different Genetic Effects of Interferon Regulatory Factor 5 (IRF5) Polymorphisms on Systemic Lupus Erythematosus in a Korean Population
HYOUNG DOO SHIN, IL KIM, CHAN-BUM CHOI, SOO OK LEE, HYE WON LEE, SANG-CHEOL BAE
The Journal of Rheumatology Nov 2008, 35 (11) 2148-2151; DOI: 10.3899/jrheum.080124
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