Abstract
Objective
In an effort to replicate additional associations of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erythematosus (SLE) in an Asian population, we examined those genetic effects in a Korean SLE cohort.
Methods
Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE.
Results
Three single-nucleotide polymorphisms (IRF5-15-1, rs2070197, and rs10488631), which showed strong and/or independent association in Caucasian populations, were not polymorphic in our Korean population. Association analysis revealed different genetic effects in Koreans compared with Caucasian populations. In addition, conditional analysis suggested independent genetic effects of 3 variant groups in the Korean population.
Conclusion
We demonstrate different genetic effects of IRF5 polymorphisms on the risk of SLE according to ethnicity.
Key Indexing Terms:Footnotes
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H.D. Shin, PhD, Laboratory of Genomic Diversity, Department of Life Science, Sogang University, and Department of Genetic Epidemiology, SNP Genetics Inc.; S.O. Lee, MS; H.W. Lee, MS, Department of Genetic Epidemiology, SNP Genetics, Inc.; I. Kim, MD; C-B. Choi, MD; S-C. Bae, MD, PhD, MPH, Department of Rheumatology, the Hospital for Rheumatic Diseases, Hanyang University.
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Supported in part by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (01-PJ3-PG6-01GN11-0002).
- Accepted for publication July 3, 2008.
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