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Abstract

Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus.

Paivi M Miettunen, Oliva Ortiz-Alvarez, Ross E Petty, Rolando Cimaz, Peter N Malleson, David A Cabral, Stephanie Ensworth and Lori B Tucker
The Journal of Rheumatology August 2004, 31 (8) 1650-1654;
Paivi M Miettunen
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Oliva Ortiz-Alvarez
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Ross E Petty
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Rolando Cimaz
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Peter N Malleson
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David A Cabral
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Stephanie Ensworth
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Lori B Tucker
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Abstract

OBJECTIVE: To investigate the associations of gender and ethnic origin with longterm outcome in childhood-onset systemic lupus erythematosus (SLE). METHODS: The study cohort consisted of 51 patients (13 males and 38 females) with childhood-onset SLE followed for > or = 5 years at the British Columbia Children's Hospital in Vancouver. Fifteen patients were Caucasian, 14 Chinese, 9 East Indian, and 13 patients were of other ethnic backgrounds: none was African-American or Hispanic. Outcome measures assessed retrospectively included Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index score (SDI), SLE-related death, need for dialysis or renal transplantation, and use of intensive immunosuppressive therapy. A SDI > or = 2 was assigned as poor outcome. RESULTS: The median age at diagnosis was 10.8 years and the median duration of followup was 7.2 years. Five-year survival was 100%; 10-year survival was 85.7% (12/14 patients). The median SDI score at last followup was 2.0 (range 0-9); 2.0 for male, 1.5 for female; 2.0 for Caucasian and 2.03 for non-Caucasian patients. Twenty-six out of 51 patients (51%) had poor outcome (SDI score > 2). Three female patients required dialysis: 2 had subsequent renal transplants. Thirty patients received intensive immunosuppressive therapy. The SDI scores, mortality, and need for intensive immunosuppressive therapy were not influenced by either gender or ethnic origin. CONCLUSION: The median SDI score was high for this cohort with childhood-onset SLE. In contrast to other published data, no association of male gender and/or non-Caucasian ethnicity with poor outcome was found in our study cohort.

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The Journal of Rheumatology
Vol. 31, Issue 8
1 Aug 2004
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Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus.
Paivi M Miettunen, Oliva Ortiz-Alvarez, Ross E Petty, Rolando Cimaz, Peter N Malleson, David A Cabral, Stephanie Ensworth, Lori B Tucker
The Journal of Rheumatology Aug 2004, 31 (8) 1650-1654;

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Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus.
Paivi M Miettunen, Oliva Ortiz-Alvarez, Ross E Petty, Rolando Cimaz, Peter N Malleson, David A Cabral, Stephanie Ensworth, Lori B Tucker
The Journal of Rheumatology Aug 2004, 31 (8) 1650-1654;
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