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Abstract

Serological bone markers and joint damage in early polyarthritis.

Louise M A Jansen, Irene van der Horst-Bruinsma, Willem F Lems, Dirkjan van Schaardenburg, Rob van de Stadt, Margret de Koning and Ben A C Dijkmans
The Journal of Rheumatology August 2004, 31 (8) 1491-1496;
Louise M A Jansen
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Irene van der Horst-Bruinsma
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Willem F Lems
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Dirkjan van Schaardenburg
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Rob van de Stadt
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Margret de Koning
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Ben A C Dijkmans
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Abstract

OBJECTIVE: To investigate the relationship between osteocalcin (OC), a marker of bone formation, and the recently developed serum marker of bone resorption, beta-C-telopeptide (beta-CTx), and radiographic damage in patients with early oligo- and polyarthritis. METHODS: Patients with peripheral arthritis of > or = 2 joints and < 2 years of symptom duration were studied. The OC and beta-CTx concentrations at baseline were correlated with disease activity and radiographic damage at baseline, and with radiographic progressive disease after 2 years (delta Sharp/van der Heijde score > or = 5). The additional value of serum bone metabolism markers to predict radiographic progressive disease was compared to that of established prognostic factors by multivariate logistic regression analysis. RESULTS: Two hundred seventy-nine patients (67% female; median age 56 yrs, range 18-83) were included in the study, of whom 73% were diagnosed with rheumatoid arthritis (RA). Baseline levels of beta-CTx (p < 0.05) were significantly correlated with baseline radiographic damage whereas OC was not. beta-CTx was also significantly (p < 0.001) related to measures of disease activity like erythrocyte sedimentation rate, C-reactive protein, and the disease activity score DAS28. Radiographic progressive disease after 2 years corresponded univariately with increased levels of beta-CTx (p < 0.001), but not with OC. In multivariate analysis, beta-CTx was not superior to other measures of radiographic progressive disease such as autoantibodies and disease activity. CONCLUSION: Increased serum levels of the bone turnover marker beta-CTx are associated with radiographic damage at baseline and radiographic progression after 2 years. However, beta-CTX is less predictive than markers already in use.

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The Journal of Rheumatology
Vol. 31, Issue 8
1 Aug 2004
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Serological bone markers and joint damage in early polyarthritis.
Louise M A Jansen, Irene van der Horst-Bruinsma, Willem F Lems, Dirkjan van Schaardenburg, Rob van de Stadt, Margret de Koning, Ben A C Dijkmans
The Journal of Rheumatology Aug 2004, 31 (8) 1491-1496;

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Serological bone markers and joint damage in early polyarthritis.
Louise M A Jansen, Irene van der Horst-Bruinsma, Willem F Lems, Dirkjan van Schaardenburg, Rob van de Stadt, Margret de Koning, Ben A C Dijkmans
The Journal of Rheumatology Aug 2004, 31 (8) 1491-1496;
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