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Abstract

Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis.

Adriana M E Sallum, Suely K N Marie, Alda Wakamatsu, Silvana Sachetti, Maria A A G Vianna, Clóvis A A Silva and Maria H B Kiss
The Journal of Rheumatology April 2004, 31 (4) 801-807;
Adriana M E Sallum
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Suely K N Marie
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Alda Wakamatsu
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Silvana Sachetti
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Maria A A G Vianna
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Clóvis A A Silva
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Maria H B Kiss
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Abstract

OBJECTIVE: To assess expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on muscle biopsy specimens from patients with untreated juvenile dermatomyositis (JDM). METHODS: Histochemical and immunohistochemical tests for ICAM-1 and VCAM-1 were performed on serial frozen sections from 27 JDM muscle biopsy specimens. ICAM-1 and VCAM-1 expression was analyzed on capillaries, perimysial and endomysial large vessels, and muscle fibers. Expression was assessed and graded semiquantitatively. RESULTS: Increased ICAM-1 expression was observed on capillaries and perimysial large vessels on semiquantitative analysis, and was statistically more evident than on endomysial large vessels. In all cases, only a few muscle vessels showed expression of VCAM-1. Expression of ICAM-1 and VCAM-1 was observed on few muscle fibers. CONCLUSION: The observation of ICAM-1 expression on muscle vessels, mainly on capillaries of patients with untreated JDM compared to controls, and VCAM-1 expression to a lesser extent, mostly on muscle vessels surrounded by inflammatory infiltrate, supports the participation of these adhesion molecules in the pathologic mechanism of vascular injury in JDM.

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The Journal of Rheumatology
Vol. 31, Issue 4
1 Apr 2004
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Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis.
Adriana M E Sallum, Suely K N Marie, Alda Wakamatsu, Silvana Sachetti, Maria A A G Vianna, Clóvis A A Silva, Maria H B Kiss
The Journal of Rheumatology Apr 2004, 31 (4) 801-807;

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Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis.
Adriana M E Sallum, Suely K N Marie, Alda Wakamatsu, Silvana Sachetti, Maria A A G Vianna, Clóvis A A Silva, Maria H B Kiss
The Journal of Rheumatology Apr 2004, 31 (4) 801-807;
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