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Abstract

Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.

Francisco Olán, Margarita Portela, Carmen Navarro, Miguel Gaxiola, Luis H Silveira, Victor Ruiz and Manuel Martínez-Lavín
The Journal of Rheumatology March 2004, 31 (3) 614-616;
Francisco Olán
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Margarita Portela
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Carmen Navarro
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Miguel Gaxiola
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Luis H Silveira
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Victor Ruiz
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Manuel Martínez-Lavín
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Abstract

Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical studies of the excised tumor confirmed abnormal VEGF production.

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The Journal of Rheumatology
Vol. 31, Issue 3
1 Mar 2004
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Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.
Francisco Olán, Margarita Portela, Carmen Navarro, Miguel Gaxiola, Luis H Silveira, Victor Ruiz, Manuel Martínez-Lavín
The Journal of Rheumatology Mar 2004, 31 (3) 614-616;

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Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.
Francisco Olán, Margarita Portela, Carmen Navarro, Miguel Gaxiola, Luis H Silveira, Victor Ruiz, Manuel Martínez-Lavín
The Journal of Rheumatology Mar 2004, 31 (3) 614-616;
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