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Abstract

Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus.

Hyung-Bae Park, Ki-Chan Kim, Jae-Hong Park, Tae-Young Kang, Hye-Soon Lee, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae-Hyun Yoo, Joe Craft and Sungsoo Jung
The Journal of Rheumatology November 2004, 31 (11) 2151-2155;
Hyung-Bae Park
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Ki-Chan Kim
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Jae-Hong Park
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Tae-Young Kang
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Hye-Soon Lee
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Tae-Hwan Kim
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Jae-Bum Jun
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Sang-Cheol Bae
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Dae-Hyun Yoo
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Joe Craft
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Sungsoo Jung
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Abstract

OBJECTIVE: To examine whether the high incidence of herpes zoster in patients with systemic lupus erythematosus (SLE) is associated with the frequency of memory T cells specific to varicella zoster virus (VZV). METHODS: Whole blood samples from 47 subjects [24 patients with SLE, 11 with rheumatoid arthritis (RA) as a disease control, and 12 healthy negative controls] were stimulated with VZV antigen, stained for surface CD4 and CD8 and intracellularly stained for the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin 4 (IL-4), and IL-10, followed by flow cytometry analyses. Correlations of VZV-specific T cell frequencies with the clinical status of patients were analyzed. RESULTS: Percentage of IFN-gamma-positive CD4 T cells was significantly lower in patients with SLE (0.043 +/- 0.009%) than in RA (0.102 +/- 0.019%) and healthy controls (0.126 +/- 0.025%) upon VZV stimulation. A similar pattern was seen in TNF-alpha-positive CD4 T cell responses. These low frequencies of VZV-specific CD4 T cells in patients with SLE were significantly related with disease activity (r = -0.435, p = 0.043). CONCLUSION: These data suggest that the high incidence of herpes zoster in patients with SLE was related to the intrinsic defects in controlling VZV reactivation, and thus VZV-specific CD4 T cell frequency could be another practical risk factor of herpes zoster in patients with SLE.

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The Journal of Rheumatology
Vol. 31, Issue 11
1 Nov 2004
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Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus.
Hyung-Bae Park, Ki-Chan Kim, Jae-Hong Park, Tae-Young Kang, Hye-Soon Lee, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae-Hyun Yoo, Joe Craft, Sungsoo Jung
The Journal of Rheumatology Nov 2004, 31 (11) 2151-2155;

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Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus.
Hyung-Bae Park, Ki-Chan Kim, Jae-Hong Park, Tae-Young Kang, Hye-Soon Lee, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Dae-Hyun Yoo, Joe Craft, Sungsoo Jung
The Journal of Rheumatology Nov 2004, 31 (11) 2151-2155;
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