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Abstract

Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria.

Thao Pham, Désirée Van Der Heijde, Marissa Lassere, Roy D Altman, Jennifer J Anderson, Nicholas Bellamy, Marc Hochberg, Lee Simon, Vibeke Strand, Thasia Woodworth, Maxime Dougados and OMERACT-OARSI
The Journal of Rheumatology July 2003, 30 (7) 1648-1654;
Thao Pham
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Désirée Van Der Heijde
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Marissa Lassere
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Roy D Altman
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Jennifer J Anderson
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Nicholas Bellamy
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Marc Hochberg
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Lee Simon
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Vibeke Strand
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Thasia Woodworth
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Maxime Dougados
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Abstract

Improvement in analysis and reporting results of osteoarthritis (OA) clinical trials has been recently obtained because of harmonization and standardization of the selection of outcome variables (OMERACT 3 and OARSI). Moreover, OARSI has recently proposed the OARSI responder criteria.This composite index permits presentation of results of symptom modifying clinical trials in OA based on individual patient responses (responder yes/no). The 2 organizations (OMERACT and OARSI) established a task force aimed at evaluating: (1) the variability of observed placebo and active treatment effects using the OARSI responder criteria; and (2) the possibility of proposing a simplified set of criteria. The conclusions of the task force were presented and discussed during the OMERACT 6 conference, where a simplified set of responder criteria (OMERACT-OARSI set of criteria) was proposed.

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The Journal of Rheumatology
Vol. 30, Issue 7
1 Jul 2003
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Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria.
Thao Pham, Désirée Van Der Heijde, Marissa Lassere, Roy D Altman, Jennifer J Anderson, Nicholas Bellamy, Marc Hochberg, Lee Simon, Vibeke Strand, Thasia Woodworth, Maxime Dougados, OMERACT-OARSI
The Journal of Rheumatology Jul 2003, 30 (7) 1648-1654;

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Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria.
Thao Pham, Désirée Van Der Heijde, Marissa Lassere, Roy D Altman, Jennifer J Anderson, Nicholas Bellamy, Marc Hochberg, Lee Simon, Vibeke Strand, Thasia Woodworth, Maxime Dougados, OMERACT-OARSI
The Journal of Rheumatology Jul 2003, 30 (7) 1648-1654;
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