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Abstract

The responsiveness of generic health status measures as assessed in patients with rheumatoid arthritis receiving infliximab.

Anthony S Russell, Barbara Conner-Spady, Alisa Mintz and Walter P Maksymowych
The Journal of Rheumatology May 2003, 30 (5) 941-947;
Anthony S Russell
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Barbara Conner-Spady
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Alisa Mintz
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Walter P Maksymowych
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Abstract

OBJECTIVE: We used a variety of health status measures in 2 groups of patients with rheumatoid arthritis (RA) to assess both the smallest distinguishable difference and the relative responsiveness to change of these measures, when used in clinical practice. METHODS: Two groups of patients were studied. Group 1: 24 patients with stable RA tested on 2 occasions; Group 2: 60 patients receiving methotrexate tested before and 14 weeks after treatment with infliximab. Assessments were made with self-completed questionnaires: the modified Health Assessment Questionnaire, Medical Outcomes Study Short Form-36 [SF-36 (SF-6D)], EuroQol, and, in some, the standard gamble. Group 2 also had joint counts, and measures of erythrocyte sedimentation rate, C-reactive protein, and hemoglobin. RESULTS: The limits-of-agreement (Bland-Altman) approach had greater confidence intervals (CI) than did CI based on +/- 2 standard errors of the measurement. Improvement with infliximab could be determined with all measures, however, but the standard gamble seemed least responsive to change. CONCLUSION: The various measures had different degrees of responsiveness, but with all it was possible to show improvement in Group 2 compared to Group 1. There was a closer association of the patient centered measures of improvement with changes in pain score than with joint counts.

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The Journal of Rheumatology
Vol. 30, Issue 5
1 May 2003
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The responsiveness of generic health status measures as assessed in patients with rheumatoid arthritis receiving infliximab.
Anthony S Russell, Barbara Conner-Spady, Alisa Mintz, Walter P Maksymowych
The Journal of Rheumatology May 2003, 30 (5) 941-947;

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The responsiveness of generic health status measures as assessed in patients with rheumatoid arthritis receiving infliximab.
Anthony S Russell, Barbara Conner-Spady, Alisa Mintz, Walter P Maksymowych
The Journal of Rheumatology May 2003, 30 (5) 941-947;
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