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Abstract

The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis.

Wako Urano, Hisashi Yamanaka, Hiroshi Tsutani, Hiroshi Nakajima, Yuko Matsuda, Atsuo Taniguchi, Masako Hara and Naoyuki Kamatani
The Journal of Rheumatology September 2002, 29 (9) 1950-1953;
Wako Urano
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Hisashi Yamanaka
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Hiroshi Tsutani
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Hiroshi Nakajima
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Yuko Matsuda
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Atsuo Taniguchi
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Masako Hara
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Naoyuki Kamatani
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Abstract

OBJECTIVE: To clarify the mechanism of decreased serum uric acid (SUA) concentrations during acute gouty arthritis. METHODS: Data from patients with acute gouty arthritis during and after an attack were investigated retrospectively. Other investigations, including changes in urinary excretion and biochemical markers, were performed prospectively. RESULTS: SUA was significantly lower in the acute phase (7.5 +/- 1.4 mg/dl) than in the intercritical phase (8.5 +/- 0.9 mg/dl) (p < 0.0001). During the acute gout phase, a normal SUA level was found in 20 of 41 patients (49%). C-reactive protein (CRP) during acute attacks was significantly correlated with plasma interleukin 6 (IL-6) and cortisol (r = 0.645, p < 0.005; r = 0.460, p < 0.05). Percentage change in SUA at onset of attack correlated with CRP and IL-6 (r = 0.762, p < 0.0001; r = 0.630, p < 0.005), as well as with increased urinary excretion of uric acid, estimated by percentage change in fractional excretion of uric acid (FEua) during attack (r = 0.447, p < 0.05). Further, change in FEua was correlated with plasma cortisol levels during the acute attack (r = 0.534, p < 0.05). CONCLUSION: Decrease in SUA during acute gouty arthritis is associated with increased urinary excretion of uric acid; an inflammatory process may play a role in the mechanism.

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The Journal of Rheumatology
Vol. 29, Issue 9
1 Sep 2002
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The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis.
Wako Urano, Hisashi Yamanaka, Hiroshi Tsutani, Hiroshi Nakajima, Yuko Matsuda, Atsuo Taniguchi, Masako Hara, Naoyuki Kamatani
The Journal of Rheumatology Sep 2002, 29 (9) 1950-1953;

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The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis.
Wako Urano, Hisashi Yamanaka, Hiroshi Tsutani, Hiroshi Nakajima, Yuko Matsuda, Atsuo Taniguchi, Masako Hara, Naoyuki Kamatani
The Journal of Rheumatology Sep 2002, 29 (9) 1950-1953;
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