%PDF-1.4
%
33 0 obj
<>
endobj
30 0 obj
<>
endobj
79 0 obj
<>stream
Acrobat Distiller 4.05 for Macintosh
2004-12-09T11:19:43Z
2024-03-28T01:35:15-07:00
QuarkXPressª: AdobePS 8.6 (219)
2024-03-28T01:35:15-07:00
application/pdf
Heather
2001-555.june
uuid:b767d50b-1dd1-11b2-0a00-320927bd3700
uuid:b767d50d-1dd1-11b2-0a00-5b0000000000
endstream
endobj
19 0 obj
<>
endobj
20 0 obj
<>
endobj
34 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
4 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
89 0 obj
[93 0 R]
endobj
90 0 obj
<>stream
1 g
/GS0 gs
0 792 m
0 792 l
f
q
-1 793 614 -794 re
W n
q
0 792.06 612 -792 re
W n
BT
/CS0 cs 0 0 0 1 scn
/GS1 gs
/TT0 1 Tf
0.0265 Tw 10 0 0 10 54 713.1616 Tm
(power to detect an odds ratio of at least 2.5 in each of the 3)Tj
0.00729 Tw 0 -1.2 TD
(populations tested [)Tj
/T1_0 1 Tf
0 Tw 7.846 0 Td
(\002)Tj
/TT0 1 Tf
-0.00011 Tc 0.0074 Tw 0.8882 0 Td
(= 0.05 \(2 sided\), power = 93% in UK,)Tj
0.03349 Tw -8.7342 -1.2 Td
[(83% in Spanish and 84% in )17.8 (T)34.8 (urkish]. Second, it is possible)]TJ
0 Tc 0.1337 Tw T*
(that a weaker association may have been missed with the)Tj
0.0759 Tw T*
(numbers, but more confidence can be based in this lack of)Tj
0.2458 Tw T*
[(association given that 3 dif)17.8 (ferent populations have been)]TJ
0 Tw T*
(studied.)Tj
-0.00011 Tc 0.05569 Tw 1.2 -1.2 Td
(In support of our finding, no association was previously)Tj
0 Tc 0.18851 Tw -1.2 -1.2 Td
(found between SLE and a dinucleotide repeat within the)Tj
0.0274 Tw T*
(TGF-\3372 gene using 81 Caucasian nuclear families)Tj
0 Tw 6.5 0 0 6.5 256.1277 608.4615 Tm
(16)Tj
0.0275 Tw 10 0 0 10 262.6276 605.1616 Tm
(. In that)Tj
0.16521 Tw -20.8628 -1.2 Td
[(study another candidate gene \(P)91.8 (ARP\) was mapped to the)]TJ
-0.00011 Tc -0.002 Tw T*
(same interval and was proposed as being responsible for the)Tj
0 Tc 0.1515 Tw T*
[(significant linkage results, using a polymorphic CA)-346.6 (dinu-)]TJ
0.18179 Tw T*
(cleotide repeat located within the promoter region of the)Tj
0.08949 Tw T*
[(gene. However)39.8 (, 3 independent studies have failed to repli-)]TJ
0.01649 Tw T*
(cate this result)Tj
-0.00011 Tc 0 Tw 6.5 0 0 6.5 112.0824 536.4616 Tm
(17-19)Tj
0 Tc 0.01649 Tw 10 0 0 10 127.2453 533.1616 Tm
(, leaving the potential candidate or candi-)Tj
0.0226 Tw -7.3245 -1.2 Td
(dates accountable for linkage to 1q41-q42 interval yet to be)Tj
0 Tw T*
(determined. )Tj
0.0287 Tw 1.2 -1.2 Td
[(In summary)64.9 (, the 4 bp insertion polymorphism within the)]TJ
0.1366 Tw -1.2 -1.2 Td
(TGF-\3372 gene does not appear to be associated with SLE.)Tj
0.0258 Tw T*
[(However)39.8 (, this does not exclude the potential role that )17.7 (TGF-)]TJ
0.02499 Tw T*
[(\3372 may have in SLE pathology)64.9 (.)]TJ
/TT1 1 Tf
-0.00011 Tc 0 Tw 0 -2.4 TD
(REFERENCES)Tj
/TT0 1 Tf
0 Tc 0.0249 Tw 8 0 0 8 61 427.1616 Tm
[(1.)-875 (T)69.8 (sao BP)110.8 (, Cantor RM, Kalunian KC, )17.7 (W)79.8 (allace DJ, Hahn BH, Rotter)]TJ
1.675 -1.25 Td
[(JI. )17.8 (The genetic basis of systemic lupus erythematosus. Proc )54.9 (Assoc)]TJ
-0.00011 Tc 0 -1.25 TD
[(Am Physicians 1998;1)36.8 (10:1)36.8 (13-7.)]TJ
-1.675 -1.25 Td
[(2.)-875.1 (Gaf)17.7 (fney PM, Kearns GM, Shark KB, et al. )54.8 (A)-219.9 (genome-wide search)]TJ
0 Tc 1.675 -1.25 Td
(for susceptibility genes in human systemic lupus erythematosus sib-)Tj
-0.00011 Tc T*
[(pair families. Proc Natl )54.8 (Acad Sci U S )54.8 (A)-219.9 (1998;95:14875-9.)]TJ
0 Tc -1.675 -1.25 Td
[(3.)-875 (Moser KL, Neas BR, Salmon JE, et al. Genome scan of human)]TJ
1.675 -1.25 Td
(systemic lupus erythematosus: evidence for linkage on)Tj
-0.00011 Tc T*
[(chromosome 1q in )54.8 (African-American pedigrees. Proc Natl )54.8 (Acad Sci)]TJ
0 Tw T*
[(USA)-220.2 (1998;95:14869-74.)]TJ
0 Tc 0.0249 Tw -1.675 -1.25 Td
[(4.)-875 (Shai R, Quismorio FP)-238.1 (Jr)39.8 (, Li L, et al. Genome-wide screen for)]TJ
1.675 -1.25 Td
(systemic lupus erythematosus susceptibility genes in multiplex)Tj
T*
(families. Hum Mol Genet 1999;8:639-44.)Tj
-1.675 -1.25 Td
[(5.)-875 (T)69.8 (sao BP)110.8 (. Lupus susceptibility genes on human chromosome 1. Int)]TJ
1.675 -1.25 Td
(Rev Immunol 2000;19:319-34.)Tj
-1.675 -1.25 Td
[(6.)-875 (Letterio JJ, Roberts )54.8 (AB. Regulation of immune responses by )17.7 (TGF)]TJ
34.675 54.671 Td
[(beta. )54.9 (Annu Rev Immunol 1998;16:137-61.)]TJ
-1.675 -1.25 Td
[(7.)-875 (Chen )36.8 (Y)129.2 (,)0.1 ( Inobe J-I, )17.7 (W)79.8 (einer HL. Induction of oral tolerance to myelin)]TJ
1.675 -1.25 Td
(basic protein in CD8-depleted mice: both CD4+ and CD8+ cells)Tj
T*
(mediate active suppression. J Immunol 1995;155:910-6.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(8.)-875.1 (Neurath MF)79.7 (, Fuss I, Kelsall BL, Presky DH, )17.7 (W)79.7 (aegell )17.7 (W)91.7 (, Strober )17.7 (W)91.7 (.)]TJ
0 Tc 1.675 -1.25 Td
(Experimental granulomatous colitis in mice is abrogated by)Tj
T*
[(induction of )17.8 (TGF-\337 mediated oral tolerance. J Exp Med)]TJ
0 Tw T*
(1996;183:2605-16.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(9.)-875.1 (Sato MN, Minoprio P)110.7 (,)-0.1 ( )54.8 (A)74.1 (vrameas S, )17.7 (T)69.7 (ernynck )17.7 (T)73.9 (.)-0.1 ( Changes in the)]TJ
0 Tc 1.675 -1.25 Td
(cytokine profile of lupus-prone mice \(NZB/NZW\)F1 induced by)Tj
T*
(Plasmodium chabaudi and their implications in the reversal of)Tj
T*
[(clinical symptoms. Clin Exp Immunol 2000;1)36.9 (19:333-9.)]TJ
-2.175 -1.25 Td
[(10.)-875 (Raz E, Dudler J, Lotz M, et al. Modulation of disease activity in)]TJ
2.175 -1.25 Td
[(murine systemic lupus erythematosus by cytokine gene delivery)64.9 (.)]TJ
T*
(Lupus 1995;4:286-92.)Tj
-0.00011 Tc -2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (Ohtsuka K, Gray JD, Stimmler MM, )17.7 (T)69.7 (oro B, Horwitz DA.)]TJ
0 Tc 2.1381 -1.25 Td
[(Decreased production of )17.7 (TGF-beta by lymphocytes from patients)]TJ
T*
(with systemic lupus erythematosus. J Immunol 1998;160:2539-45.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(12.)-875.1 (Nishimura DY)128.8 (, Purchio )54.8 (AF)79.7 (, Murray JC. Linkage localization of)]TJ
0 Tc 2.175 -1.25 Td
(TGF\3372 and the human homeobox gene HLX1 to chromosome 1q.)Tj
T*
(Genomics 1993;15:357-64.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(13.)-875.1 (Alansari )54.8 (A, Hajeer )54.8 (AH, Bayat )54.8 (A, Eyre S, Carthy D, Ollier )17.7 (WE. )17.7 (T)69.7 (w)0.1 (o)]TJ
0 Tc 2.175 -1.25 Td
(novel polymorphisms in the human transforming growth factor beta)Tj
T*
(2 gene. Genes Immun 2001;5:295-6.)Tj
-2.175 -1.25 Td
[(14.)-875 (T)69.8 (an EM, Cohen )54.8 (AS, Fries JF)79.8 (, et al. )17.7 (The 1982 revised criteria for the)]TJ
-0.00011 Tc 2.175 -1.25 Td
[(classification of systemic lupus erythematosus. )54.8 (Arthritis Rheum)]TJ
0 Tc 0 Tw T*
(1982;25:1271-7.)Tj
0.02499 Tw -2.175 -1.25 Td
[(15.)-875 (Martin ER, Lai EH, Gilbert JR, et al. SNPing away at complex)]TJ
2.175 -1.25 Td
(diseases: analysis of single-nucleotide polymorphisms around)Tj
T*
[(APOE in )54.8 (Alzheimer disease. )54.8 (Am J Hum Genet 2000;67:383-94.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(16.)-875.1 (T)69.7 (sao BP)110.7 (, Cantor RM, Grossman JM, et al. P)91.7 (ARP)-238.2 (alleles within the)]TJ
0 Tc 2.175 -1.25 Td
(linked chromosomal region are associated with systemic lupus)Tj
T*
[(erythematosus. J Clin Invest 1999;103:1)36.8 (135-40.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(17.)-875.1 (Delrieu O, Michel M, Frances C, et al. Poly\(ADP-ribose\))]TJ
0 Tc 2.175 -1.25 Td
(polymerase alleles in French Caucasians are associated neither with)Tj
-0.00011 Tc T*
(lupus nor with primary antiphospholipid syndrome. GRAID)Tj
T*
[(Research Group. Group for Research on )54.8 (Auto-Immune Disorders.)]TJ
0 Tc T*
(Arthritis Rheum 1999;42:2194-7.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(18.)-875.1 (Criswell LA, Moser KL, Gaf)17.7 (fney PM, et al. P)91.7 (ARP)-238.2 (alleles and SLE:)]TJ
0 Tc 2.175 -1.25 Td
[(failure to confirm association with disease susceptibility)64.9 (. J Clin)]TJ
T*
(Invest 2000;105:1501-2.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(19.)-875.1 (Boorboor P)110.7 (, Drescher BE, Hartung K, et al. Poly\(ADP-ribose\))]TJ
2.175 -1.25 Td
(polymerase polymorphisms are not a genetic risk factor for)Tj
0 Tc T*
(systemic lupus erythematosus in German Caucasians. J Rheumatol)Tj
0 Tw T*
(2000;27:2061.)Tj
ET
/CS0 CS 0 0 0 1 SCN
54 54 m
558 54 l
S
BT
/TT2 1 Tf
-0.00011 Tc 0.02499 Tw 8 0 0 8 54.5 35.9844 Tm
(Alansari, et al: TGF-\3372 and SLE)Tj
0 Tc 0 Tw 60.9375 -0.0313 Td
(1191)Tj
ET
0 0 0 0 scn
/GS0 gs
100.25 59.08 407.5 -10.83 re
f*
0.5 w
100.25 59.08 407.5 -10.83 re
S
Q
Q
q
0 0 612 792 re
W n
BT
0 g
/GS2 gs
/T1_1 8 Tf
120.092 51 Td
(Personal non-commercial use only. The Journal of Rheumatology Copyright\
\251 2002. All rights reserved.)Tj
ET
Q
BT
0 g
/GS2 gs
/T1_2 1 Tf
10 0 0 10 540 17 Tm
( )Tj
0 0.48627 0.77255 rg
/GS2 gs
-7.22298 0 Td
(www.jrheum.org)Tj
0 g
/GS2 gs
-16.72996 0 Td
(Downloaded on March 28, 2024 from )Tj
ET
endstream
endobj
9 0 obj
<>
endobj
72 0 obj
<>
endobj
84 0 obj
<>
endobj
41 0 obj
<>
endobj
7 0 obj
<>
endobj
36 0 obj
<>
endobj
38 0 obj
<>
endobj
66 0 obj
<>stream
HVpMg}9ބ(yȃs{$$x\tBEo4WR1)22*]cې:Mc0(蚎i騲g&vfgϗ~;= ڡ
ǽ˿WTұOGXJ@-Zڱ(o m@Y匊gG3f/*e(w*/
l|Or
i> s+,-1{Nq Ce%*+#;/jt݈ͦ[`j+V~kN&Ds(RD:CBl>p)c+<.a-a!s*}1(%AHlrFF`=h
/#T?
+/cp;P:x'bax1j0|S8*m _Y'mr8:14>Eͪ
aWxQ%T)jbTf%GH"3yB+ITRk|HNVwh4Zv:=z)45T:j9h+ݪ[FvFhxH:c9yҦ`:QYBVs=빑~'ܙͣy(&q:(zLxvd\.zބ<~k*zy4kmܙh7Dn`qy'k&y^)@?Kr
ݙ-603ZÑMgeh;2W5`?#( L%Pho!Ì7/%e>d:!8a_;{OjܙM KX&PP{JX2{ia8jb,LX' TgӌO`^1#svMCh$*q{i7с0sm"!aA_wfdTfK|1P8 uw얭l`:f1=i&|)4hЎDEX_)B[J`<<:lu`X
H.24>|12ǺiۓI.$IJ!
&m =OʢO18(?,E9dc&\;h5s}O孥leլnRQgZՎuu>?F&汆}mM%9^#Um.箤js9/!Oy2ojSaٹEM'^q$QR;Jos7ܚ!;o;9`m|?|alϏ
~AG"FR'R<j<=N_֫5
W_Y/2`VR0ۺ;NcG 5q J['13)nJ[Pux%P3`7Q)IfÌa6TRϮD3Ts=ߞ=콻L[NWaPUKsE^bՇ#lGh-wR(#.tH`x^5xw^~;?@d:X{`}wP9&}B
7!Z\6[wqoyyRP>m=ۥy>dQy=D2ru(1@\5[; g7kR{gC[@*AZX+akgf>r#dipQhxU{R>2th)C~2Hd5&0Q|
Dk]! l
`U> B0+ ]! &&@B 0*u Bz
y
@= Bvh
Q. Bv
)bCNJ
ڊDqk;fg[*kIvvq].^i/v8kdo@X k40W'vs=Sʬԉ['ՉkD_['*d+Wsz^h=y&>|
ϥeYRIuVgᏑ_R8/BMO
R+
X
hW/0uMjnD.
(B>xpIދ5iWN`W8#ƒ:N
^wOniR8J(d=F]z=hQz]FISz[x$K${
`{6$x
vz+5|IX`]睤?gK/(
i(7Z ފ#09asxfNgYOMjx@?A&y /%\.